Notes

Pure fetal histology subtype had been related to greater prognosis of children together with hepatoblastoma: A new Chinese population-based review.
Circ_0037655 expression was inhibited after SEV treatment in glioma cells. The effects of SEV on glioma cell behaviors were attenuated by upregulation of circ_0037655. Circ_0037655 interacted with miR-130a-5p and miR-130a-5p targeted RPN2. Circ_0037655 or miR-130a-5p regulated the anti-tumor function of SEV in glioma by targeting miR-130a-5p or RPN2. Circ_0037655 affected the expression of RPN2 via targeting miR-130a-5p. Circ_0037655 relieved SEV-induced glioma growth inhibition in vivo by mediating miR-130a-5p and RPN2 levels. SEV inhibited the malignant progression of glioma cells partly by regulating the circ_0037655/miR-130a-5p/RPN2 axis.Phosphorylation of N-methyl-D-aspartate receptor (NMDAR) is widely regarded as a vital modification of synaptic function. Various protein kinases are responsible for direct phosphorylation of NMDAR, such as cyclic adenosine monophosphate-dependent protein kinase A, protein kinase C, Ca2+/calmodulin-dependent protein kinase II, Src family protein tyrosine kinases, cyclin-dependent kinase 5, and casein kinase II. The detailed function of these kinases on distinct subunits of NMDAR has been reported previously and contributes to phosphorylation at sites predominately within the C-terminal of NMDAR. Phosphorylation underlies both structural and functional changes observed in chronic pain, and studies have demonstrated that inhibitors of kinases are significantly effective in alleviating pain behavior in different chronic pain models. In addition, the exploration of drugs that aim to disrupt the interaction between kinases and NMDAR is promising in clinical research. Based on research regarding the modulation of NMDAR in chronic pain models, this review provides an overview of the phosphorylation of NMDAR-related mechanisms underlying chronic pain to elucidate molecular and pharmacologic references for chronic pain management.
To evaluate the microbiological characteristics and risk factors of severe ophthalmia neonatorum (ON) in Southwest China.

In this retrospective review, data on demography, microbiological results, and risk factors were analyzed. Data were obtained from medical records of patients with severe ON treated at Children's Hospital of Chongqing Medical University from January 2015 to December 2019. To understand the risk factors for severe ON, maternal and neonatal factors were compared between the severe and non-severe ON groups.

A total of 1397 neonates with ON were included, of whom 12% (n = 172) had severe ON, and 88% (n = 1225) had non-severe ON. Microbial detection and drug susceptibility tests were performed on 169 patients with severe ON. Culture results were positive for 76 patients, with gram-positive bacteria in 71.1% (n = 54), gram-negative bacteria in 25.0% (n = 19), and multiple microorganisms in 3.9% (n = 3) neonates. The most commonly detected organisms were Staphylococcus aureus (29%) and Staph. epidermis (27%), followed by Escherichia coli (8%). Neisseria gonorrhea (8%), Moraxella catarrhal (5%), Streptococcus pneumoniae (4%), Haemophilus influenza (4%), and Chlamydia trachomatis (1%). The main risk factors for severe ON were obstruction of the nasolacrimal duct (χ
 = 10.794, P = 0.001), meconium aspiration syndrome (χ
 = 6.252, P = 0.012), and cesarian section (χ
 = 5.118, P = 0.024). Neonatal ocular prophylaxis was a protective factor for severe conjunctivitis (χ
 = 6.905, P = 0.009).

Staphylococcus is the most common pathogen of severe ON. Nasolacrimal duct obstruction (NLDO) is a risk factor for ON.
Staphylococcus is the most common pathogen of severe ON. Nasolacrimal duct obstruction (NLDO) is a risk factor for ON.This study investigated the seasonal and temporal variations in the extent and source of physiochemical and toxic trace elements in the Lakhodair landfill site of Lahore, Pakistan. For this purpose, systematic composite samples were collected every month, consecutively for 1 year, and analyzed for different physiochemical parameters and trace elements. The results of TDS, TSS, COD, NH3-N, BOD5, sulfate, sulfides, phenolic compounds, and oil and grease were higher than the national environmental quality standard (NEQs). The concentrations of trace elements, especially Mn (1.7 mg/L) and Cd (0.05 mg/L), were above the MPL, while Fe (14 mg/L), Ni (1.6 mg/L), and Zn (6.7 mg/L) were also found higher than the NEQs in some samples. In Lakhodair leachates, the TDS, COD, NH3-N, BOD5, sulfides, and Cl- have high concentration coefficient (i.e., CC 3 to > 6), which falls in the category of considerable to high contamination and risk level, while the remaining parameters were in the category of low to moderate contamination (CC 1 to ≤ 3) and moderate risk. The lower BOD5/COD ratio ( less then  0.1) in spring and autumn seasons represents the active methanogenesis and anaerobic activities in the Lakhodair landfill site. selleck chemicals The anaerobic and methanogenesis activities enhance the redox reaction as a result of CO2 emission, which increases the pH, TDS, COD, Cl-, BOD5, NH3-N, sulfides, and phenolic compounds in the leachate site. However, the lower concentrations of some trace elements in leachate may be because of an anaerobic process that may immobilize the trace elements. It is presumed that the trace elements in the Lakhodair landfill may be in a metastable state, which is difficult to leach out. It is hereby recommended that leachate produced in the Lakhodair landfill site should be handled carefully to limit the environmental and health implications.Heavy metal and metalloid pollution is a matter of concern in animal, human and environmental health (One Health) and also in wildlife conservation worldwide. Studying wild mammals in toxicology has been contributing significantly to our knowledge, namely to find out the most critical regions, to understand bioaccumulation and biomagnification phenomena or to evaluate their toxic effects. However, not all the animal tissues and organs provide the same information or should be interpreted in the same way. The best sample to use will depend on the objectives and conditions of the study. This review aims to compare invasive and non-invasive samples to biomonitor heavy metals, providing a brief resume of their advantages, limitations and examples of use. Further research, using a wider range of mammalian species, is required to establish what information can be obtained in biomonitoring studies that use non-invasive samples (such as hair, faeces and parasites) and/or invasive samples (such as blood, liver, kidney, bone and other organs).There is a lack of proper research that highlights the impact of institutional quality (IQ) and renewable energy consumption (REC) on the carbon emission (CE). The significance of IQ and REC in the achievement of zero CE is highlighted in this research. The current research reports the effects of these important factors on the consumption-based carbon emissions in the G-7 countries from 1995 to 2018. Based on the outcome of the cointegration test, the long-run connection is recognized between IQ, REC, GDP, exports, imports, and consumption-based CE. The findings also validated that there exist significant decrease and increase in the CE in both the short and long run; for instance, IQ, REC, and exports decrease the CE, while imports and GDP increase the CE. The estimates of causality test showed that policies aimed at improving IQ, REC, GDP, exports, and imports have a significant impact on the CE. Consequently, based on these results, policymakers in the G-7 must prioritize IQ and REC to enhance environmental quality and attain carbon neutrality.This research aims to assess the ecological status of the Hrazdan river (Armenia) section that flows through Yerevan. The distribution of potentially toxic elements (PTE) (Cr, V, As, Zn, Cu, Ni, Co, Mn, Pb, Ti, Mo, Fe, and Ba), the bottom sediments pollution level, and the ecological risk were assessed employing the single pollution index (SPI), the enrichment factor (EF), the geo-accumulation index (Igeo), and the potential ecological risk index (RI). On sampling sites, water quality parameters (turbidity, DO, electrical conductivity (EC), salinity, TDS, pH, temperature °C) were measured as well. The correlation analysis revealed a significant correlation between Zn-Cu, Pb; Cu-Pb, Mo; Co-Fe, Ti pointing out similar sources and origination of these elements. The results indicated that the content of the studied elements in the Hrazdan bottom sediments exceeded the background content in urban soils, which was due to a set of geological and anthropogenic factors. High contents of elements were determined on the sampling sites spatially confined to the residential and industrial areas. According to EF and Igeo data, the priority bottom sediment contaminants are As, Pb, Mo, Zn, V, and Cu. The RI value varies from 196 to 316 with the mean of 246 which corresponds to the moderate-level ecological risk. On the whole, a moderate (77.8%) and a considerable (22.2%) ecological risk was revealed. The major source of Pb, Cu, Zn, and Mo contents was identified as the surface runoffs in the urban environment. This was verified by the cluster analysis results.In this study, we synthesized recyclable Fe3O4-functionalized MIL101(Fe) chitosan composite beads for the removal of tetracycline (TC), doxycycline (DC) and ciprofloxacin (CFX) antibiotics from aqueous streams. More than 99% removal efficiency for each antibiotic was achieved at optimum pH, dosage, concentration and contact time. Langmuir adsorption isotherms and pseudo-second-ord er kinetic model were suitable with correlation coefficient values close to 1 for all the antibiotics. Adsorption capacities of 45.33, 33.20 and 31.30 mg g-1 for TC, DC and CFX, respectively, were reported by the synthesized Fe3O4-functionalized MIL101(Fe) chitosan composite beads. The Fe3O4-functionalized MIL101(Fe) chitosan composite beads were also tested for their regeneration ability, and a remarkable regeneration ability over up to 5 cycles was observed. The adsorption of TC, DC and CFX on the surface of Fe3O4-functionalized MIL101(Fe) chitosan composite beads was governed by the π-π interaction, H-bonding and electrostatic interaction between the antibiotics and adsorbent due to protonation, deprotonation and cation exchange in the aqueous solution. These results showed a good prospect for applying the reported beads towards removing antibiotics from pharmaceutical industry wastewater.Legacy effects of P in agricultural soils have been highlighted in recent literature. However, co-accumulation and release of organic P (Po) have often been ignored in current agro-environmental assessments. The mineralizable Po fraction has a potential to increase the activity of phosphate in pore water, increasing fertility or degrading water quality. In this study, the effects of agricultural management practices (fertilizer applied corn-soybean rotation cropland and dairy manure applied pasture) on the Po/phosphate ratio were investigated in P-rich (290-1232 mg kg-1) agricultural soils and adjacent ditchwater using experimental soil-water chemistry. The effect of agricultural management was significant on both Po and the Po/phosphate ratio in soil and adjacent ditchwater. The Po content, dominated by orthophosphate monoesters, in the manure-amended pasture (average ~ 245 mg kg-1) was significantly greater than that in the fertilizer-applied cropland (average 103 mg kg-1). The Po/phosphate ratio was also significantly greater in the manure-amended pasture (0.
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