Notes

Retrospective evaluation of the impact associated with non-oncologic chronic drug treatment for the tactical in people together with bladder cancers.
The primary outcome was atrial tachyarrhythmia (AA; atrial tachycardia [AT], atrial flutter [AFl] or AF) recurrence between days 91 and 365 post catheter ablation. find more Patient follow-up included 14-day continuous ambulatory ECG monitoring at 3, 6, and 12 months after catheter ablation. Three questionnaires were administered during the trial- the EuroQuol-5D (EQ-5D) quality of life scale, the Canadian Cardiovascular Society Severity of Atrial Fibrillation scale, and a patient satisfaction scale.

The AWARE trial was designed to evaluate whether a novel approach to catheter ablation reduced the risk of AA recurrence in patients with symptomatic paroxysmal AF.
The AWARE trial was designed to evaluate whether a novel approach to catheter ablation reduced the risk of AA recurrence in patients with symptomatic paroxysmal AF.
Interleukin-36 (IL-36) family is associated with several fibrosis-related disorders and connective tissue diseases. However, their expression in idiopathic pulmonary fibrosis (IPF) and connective tissue disease-interstitial lung disease (CTD-ILD) is unknown.

We included 19 CTD-ILD patients, 16 IPF patients, and 27 healthy control subjects. Determination of serum concentrations of IL-36α, IL-36γ and IL-36 receptor antagonist (IL-36Ra) was performed by ELISA. The value of biomarkers for the diagnosis and assessment of ILD was assessed by lung function tests and high-resolution computed tomography.

Serum concentrations of IL-36α and IL-36γ in patients with CTD-ILD and IPF were significantly higher than that in healthy controls, whereas serum IL-36Ra concentrations were not significantly different between the 3 groups. Increased IL-36 levels correlated with disease severity in IPF patients. ROC curve analysis showed that the AUC was 0.9931 for IL-36α and 0.8194 for IL-36γ in IPF group. In CTD-ILD group, the AUC was 0.9825 for IL-36α and 0.7973 for IL-36γ.

We demonstrated an imbalance in the agonist and antagonist profiles of IL-36 cytokines in ILD. IL-36 cytokines may be a new diagnostic or therapeutic target in ILD, especially in IPF.
We demonstrated an imbalance in the agonist and antagonist profiles of IL-36 cytokines in ILD. IL-36 cytokines may be a new diagnostic or therapeutic target in ILD, especially in IPF.The present study developed and evaluated nano-adsorbents based on zirconium oxide and graphene oxide (ZrO2/GO) as a novel adsorbent for the efficient removal of ammonia from industrial effluents. Fourier transform infrared (FTIR) spectroscopy, Field Emission Scanning Electron Microscope, Energy-dispersive X-ray Spectroscopy, and X-ray diffraction were used to evaluate and identify the novel adsorbent in terms of morphology, crystallography, and chemical composition. The pH (7), adsorbent quantities (20 mg), adsorbent contact time (30 min) with the sample, and initial ammonia concentration were all tuned for ammonia uptake. To validate ammonia adsorption on the ZrO2/GO adsorbent, several kinetic models and adsorption isotherms were also utilized. The results showed that the kinetics of ammonia adsorption are of the pseudo-second order due to high R2 (>0.99) value as compared first-order (R2 = 0.52). The chemical behavior and equilibrium isotherm were analyzed using the isotherm models and Langmuir model provided high R2 (>0.98) as compared Freundlich (>0.96). Hence, yielding a maximum uniform equilibrium adsorption capacity of 84.47 mg g-1. The presence of functional groups on the surface of graphene oxide and ZrO2 nanoparticles, which interact efficiently with ammonia species and provide an efficient surface for good ammonia removal, is most likely to be responsible.In the present work, a three-dimensional electrode reactor (3Der) using pallet activated carbon (PAC), as particle electrodes, was investigated to degrade non-biodegradable organic pollutants in pharmaceutical wastewater and steel industry wastewater. The effect of operating parameters, such as pH, electrode distance, O2 flow rate, and current density was investigated. The TOC removal efficiency in 3Der was achieved at the highest mineralization yield of 94.1% after 180 min electrolysis, which was 10-19% higher than the two-dimensional electrode reactor (2Der). The higher performance of the 3Der can be attributed to the indirect and direct oxidation mechanisms. The impact of supporting electrolytes was decreased in order as chloride > nitrate > sulfate. The morphology of sludge and the presence of Fe(OH)3 after Fenton-oxidation were investigated. 3Der system improved biodegradability of pharmaceutical wastewater after electro-Fenton treatment at a PW/SIW ratio of 31 (BOD5/COD = 0.6). Hence, the mechanism of 3Der/PAC, as particle electrodes was also proposed. 3Der with PAC particle electrodes using steel industry wastewater as a catalyst is an exciting technique for remediation of organic contaminated pharmaceutical wastewater.PM2.5 samples were collected during 2017-2018 at two Eastern Mediterranean urban sites in Greece, Athens and Patra, in order to study the abundances, the seasonal trends, the sources and the possible impact of gas phase pollutants on organosulfate formation. Each of the studied groups, except that of aromatic organosulfates, presented higher concentrations in Patra compared to those measured in Athens, from 1.1 (nitro-oxy organosulfates) to 3.6 times (isoprene organosulfates). At both sites, isoprene organosulfates was the dominant group which accounted on average for more than 50% of the total measured organosulfates, with the contribution being more than 80% during summer. Strong seasonality was observed at both sites, regarding the isoprene organosulfates, with an almost 21-fold increase from winter to summer. The same pattern, but to a lesser extent, was also observed for monoterpenes organosulfates at both sites. Alkyl organosulfates followed an identical seasonal trend with the highest mean concentratiotransportation emissions on the formation of monoterpene nitro-oxy organosulfates is indicated while the correlation of naphthalene organosulfates with low molecular weight polycyclic aromatic hydrocarbons suggests that vehicle emissions may be a significant source. In Patra, the possible contribution of sea on methyl sulfate levels is denoted.In this study, a novel polydopamine (PDA)-modified metal organic frameworks (MOFs) catalyst (MIL/PDA) was successfully fabricated to activate persulfate (PS) for the degradation of sulfamethoxazole (SMX) in wastewater. The experimental results indicated that PDA-modified catalyst exhibited superior catalytic performance and enhanced the degradation of SMX (91.5%) compared to pure MOFs. The physical-chemical properties of the MIL/PDA catalyst were comprehensively characterized, and the applications in the catalytic degradation of SMX were evaluated. It was found that the modification of PDA enhanced the electron transfer, while promoting the redox cycle of Fe(III)/Fe(II), which in turn boosted the production of active oxygen species. Furthermore, MIL/PDA showed high stability and reusable performance over multiple cycles. Both radical and non-radical pathways were jointly involved in the activation process of PS were confirmed by quenching experiments combined with electron paramagnetic resonance (EPR). Based on this, the possible mechanism of the catalytic reaction was investigated. Finally, five degradation pathways of SMX degradation were proposed according to the results of liquid chromatography-mass spectrometry (LC-MS). This work provided a new insight into the design of novel and efficient heterogeneous catalysts for advanced wastewater treatment.Tire wear particles (TWPs) have been characterized as microplastics in recent years, and many of these TWPs will be eventually deposited in coastal areas, leading to adverse effects to marine organisms. Results of the acute toxicity test in this study showed that the 96-h LC50 values of the particles and leachate were 771.4 mg/L (95% CI = 684.4-869.6 mg/L) and 5.34 g/L (95% CI = 4.75-6.07 g/L), respectively. The chemical constituents of TWP and the leachate are very complex, and little research has been conducted to determine which of these constituents contribute to the toxicity of TWP leachate to marine organisms. Therefore, the composition of the TWP and leachate was analyzed, and a variety of chemicals were identified, including metals (Mn, Zn, etc.) and organic compounds (cyclohexanthiol, 4-ethyl-1,2-dimethylbenzene, benzothiazole, stearic acid, N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine, etc.). In addition, the marine copepod Tigriopus japonicus was applied as a model species in the toxicity identification evaluation study to characterize, identify and confirm the toxicity-causing substances in the TWP leachate. Zn was identified and confirmed as the main toxicant contributing to the toxicity. Furthermore, Zn concentrations in the leachate over time were investigated. The release of Zn from TWPs to the aquatic environment was slow, and conformed to a parabolic model with a release constant k of 2.06. The organic component, benzothiazole, exhibited an antagonistic effect with zinc in the acute toxicity of the TWP leachate.In this paper, new adsorbents with high mechanical strength chitosan-graphene oxide (CS-GO) and chitosan-titanium dioxide (CS-TiO2) were synthesized by using glutaraldehyde as crosslinking agent, and the adsorption behavior of Pb (II) and V (V) on them were investigated. The materials were characterized by scanning electron microscopy (SEM-EDS), Fourier transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS). The effects of initial metal ion concentration and contact time on the removal of V (V) and Pb (II) by CS-GO and CS-TiO2 were investigated. Characterization results showed that the hydroxyl group of GO/TiO2 reacted with the amino group of chitosan. A comparison of the kinetic models against experimental data showed that the kinetics react system was best described by the pseudo-second-order model. indicating that chemical adsorption was the main adsorption force. the Langmuir adsorption model and Freundlich model agreed well with the experimental data. The removal capacity of Pb (II) by CS-GO and CS-TiO2 were lower than those of V (V). The uncross-linked -OH and CO were the main adsorptive sites for Pb (II) removal, while uncross-linked -OH and -NH2 played an important role in removing V (V). These findings provided insights on the removing lead and vanadium pollution.Heavy metals play an important role in inducing fine particulate matter (PM2.5) related cardiovascular disease (CVD). However, most of the past researches concerned the associations between CVD mortality and the PM2.5 mass, which may not reveal the CVD mortality risk contributed by heavy metals in PM2.5. This study explored the correlations between individual heavy metals in PM2.5 and CVD mortality, identified the heavy metals that significantly contribute to PM2.5-related CVD, heart disease (HD), and cerebrovascular disease (CEV) mortality, and attempted to establish corresponding source control measures. Over a 2-year study period, PM2.5 was sampled daily in Guangzhou, China and analyzed for heavy metals. The airborne pollution and weather data, along with CVD, HD, and CEV mortality, were obtained at the same time. The excess risk (ER) of mortality was linked to the individual heavy metals using a distributed lag non-linear model. PM2.5 and most heavy metals showed significant correlations with the CVD, HD, and CEV mortality; the largest cumulative ER (LCER) values of CVD mortality associated with an interquartile range increase in the levels of lead, cadmium, arsenic, selenium, antimony, nickel, thallium, aluminum, iron, and PM2.
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