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Insights in to the newly created N-doped co2 facts regarding Q235 metallic corrosion retardation within acidizing press: Reveal multidimensional research.
To compare survival rates of surgically treated advanced epithelial ovarian cancer patients before and after a programmatic change in surgical approach from standard surgery towards ultra-radical surgery.

247 patients with FIGO stage IIIB-IV ovarian, tubal, and primary peritoneal carcinoma were operated during 2013-2019 either by primary or interval cytoreduction in Tampere University Hospital, Finland. Group 1 (n = 122) patients were operated during 2013 and February 2016. Group 2 patients (n = 125) were operated between March 2016 and March 2019, when a systematic change in surgical approach towards more extensive surgery was implemented.

The complete resection (R0) rate increased significantly from 17.2% (21/122) to 52.0% (65/125) within the study period (p < 0.001). The median progression-free survival (PFS) was 15.6 months vs 19.3 months (p = 0.037), and the median overall survival (OS) was 33.5 months vs 54.5 months in Groups 1 and 2, respectively (p = 0.028). Median OS for stage III patients in Group 1 was 36.1 months (95% CI 27.4-44.8) but could not be reached in Group 2 (p = 0.009). In Stage IV patients, OS was 32.0 months (16.4-47.7) and 39.3 months (24.8-53.8) in Group 1 and 2, respectively (p = 0.691). Multivariable Cox regression analysis revealed that OS was independently affected by the amount of residual tumor and complication grade.

The change of surgical approach towards maximal surgical effort improved both progression-free and overall survival. The survival benefit was unquestionable for stage III patients but did not reach statistical significance in stage IV patients.
The change of surgical approach towards maximal surgical effort improved both progression-free and overall survival. The survival benefit was unquestionable for stage III patients but did not reach statistical significance in stage IV patients.
The aims of the present study were to assess the oncological outcomes of platinum-sensitive recurrent ovarian cancer patients undergoing secondary cytoreduction (SCS) after treatment with neoadjuvant chemotherapy (NACT) and interval debulking surgery (IDS) at diagnosis and to compare the performance of different selection models in these patients.

Retrospective, observational, single-center cohort study including patients with platinum-sensitive recurrent epithelial ovarian cancer with abdominal/inguinal/cardiophrenic disease between November 2012 and November 2020. Patients were selected as surgical candidates with PET/CT-scan and with diagnostic laparoscopy.

272 patients were included in the study. Of these, 165 (60.7%) patients were treated with PDS at diagnosis and 107 (39.3%) with IDS. SCS was performed in 178 (65.4%) cases, with complete gross resection achieved in 155/178 (87.1%). No progression-free survival (PFS) difference was demonstrated when patients treated with PDS were compared with thossafely applied to IDS patients.The recent increase in outbreaks of pathogenic bacteria and antimicrobial resistance represent major public health problems. Being the leading cause of death in humans, the bacterial infections need to be accurately and quickly diagnosed. Hence, the development of fast, cost-effective, sensitive and specific strategies for the detection of the targeted bacterium is of utmost importance. Chk2 Inhibitor II This review presents a systematic, critical evaluation of the recent analytical methods for the characterization and diagnosis of infections caused by Pseudomonas aeruginosa. The clinical manifestations, incidence and treatment of the P. aeruginosa infection and the associated quorum sensing, biofilm formation and virulence factors are also discussed. An overview of a variety of analytical methods for the detection of P. aeruginosa is provided, including whole-cell detection (microbiological methods, biosensors), antigens, DNA, and relevant markers (quorum sensing molecules, virulence factors) detection. The latest trends in analytical methods, especially sensors, are the orientation towards portability and on-site detection. The efforts made so far to achieve these goals in the detection of P. aeruginosa and its markers are also presented and discussed in this review. The strengths and weaknesses of the current detection methods are evaluated, while exploring potential routes for further development.Due to the cytotoxic potential of even low doses of Pd2+, the development of its detection and detoxification strategies is highly demanding. In this paper, we developed a water-soluble fluorescent probe IMQU-8 with a new scaffold for Pd2+ sensing. IMQU-8 can detect Pd2+ with high selectivity and sensitivity and has a good detection limit of 2.5 nM under physiological conditions. Its sensing mechanism has been revealed through job plot experiments and HRMS, FT-IR, 1H NMR and DFT calculations, which demonstrated that the N atoms of the pyridyl group and imino group are crucial for Pd2+ sensing. Fluorescence lifetime assessment indicated that IMQU-8 and IMQU-8-Pd have almost identical fluorescence lifetimes, implying that IMQU-8 undergoes static quenching toward Pd2+. Additionally, IMQU-8 has been successfully applied to image Pd2+ in living cells. Since IMQU-8 and its coordinated complex IMQU-8-Pd exhibit low toxicity, IMQU-8 has been applied for the detoxification of Pd2+ in living cells.We fabricated a novel N,S-co-doped carbon/Co1-xS nanocomposite (NSC/Co1-xS) using a facile sol-gel approach, which featured a multiporous structure, abundant S vacancies and Co-S nanoparticles filling the carbon-layer pores. When the Co1-xS nanoparticles were anchored onto the surface of N,S-co-doped carbon, a synergistic catalysis action occurred. The NSC/Co1-xS nanocomposites possessed both peroxidase-like and oxidase-mimetic dual-enzyme activities, in which the oxidase-mimetic activity dominated. By scavenger capture tests, the nanozyme was demonstrated to catalyze H2O2 to produce h+, •OH and •O2-, among which the strongest and weakest signals were h+ and •OH, respectively. The multi-valence states of Co atoms in the NSC/Co1-xS structure facilitated electronic transfer that enhanced redox reactions, thereby improving the resultant color reaction. Based on the NSC/Co1-xS's enzyme-mimetic catalytic reaction, a visual colorimetric assay and Android "Thing Identify" application (app), installed on a smartphone, offered detection limits of 1.93 and 2.51 mg/dl, respectively, in human serum samples. The selectivity/interference experiments, using fortified macromolecules and metal ions, demonstrated that this sensor had high selectivity and low interference potential for cholesterol analysis. Compared to standard assay kits and previously reported visual detection, the Android smartphone-based assays provided higher accuracy (recoveries up to 93.6-104.1%), feasibility for trace-level detection, and more convenient on-site application for cholesterol assay due to the superior enzymatic activity of NSC/Co1-xS. These compelling performance metrics lead us to posit that the NSC/Co1-xS-based nanozymic sensor offers a promising methodology for several practical applications, such as point-of-care diagnosis and workplace health evaluations.Copper levels in body fluids provide an important reference for the diagnosis of Wilson's disease, which associated with blood abnormalities, kidney and cardiovascular disease, and neuropathy. Metal-organic frameworks (MOF) can easily realize dual-emission from single excitation as ratiometric fluorescence sensing and visible detection platform with the intensity ratio of two emissions for simple, rapid, sensitive, and specific analysis of biological samples. Here, we rationally designed a dual-emission Eu-MOF with dual-ligand strategy, denoted as Eu-DATA/BDC. While terephthalic acid (H2BDC) was selected to sensitize Eu3+ ions for the antenna effect emission, 2,5-diaminoterephthalic acid (H2DATA) maintained its own emission and was used to identify Cu2+ ions. Thus, dual-emission from Eu-DATA/BDC and specific recognition of Cu2+ ions were realized for ratiometric sensing of Cu2+ ions. A wide linear concentration range (1-40 μM), low detection limit (0.15 μM), and fast response (less than 10 s) were realized. The color change also achieved the visible detection by naked eye. Copper levels were tested with human serum samples and compared to the ICP-OES results, confirmed the potential of Eu-DATA/BDC probe in the diagnosis of Wilson's disease. The response mechanism to Cu2+ ions was proposed as electron transfer between host and guest for fluorescence quenching. Thus, dual-ligand is a simple and efficient strategy to prepared dual-emission Eu-MOF for the ratiometric sensing and visible detection.In this study, a simple one-step method was applied for extraction and determination of lead and cadmium. The significant variables in extraction and pre-concentration were identified using analysis of variance and their behavior was modeled. Dual-template imprinted polymer was synthesized on modified Mesoporous silica structures coated with Fe3O4 magnetic nanoparticles. The optimum condition was 6.12 for pH, 40.62 mg for the polymer amount and 17.38 for the ultrasonic time. Concentration range, correlation coefficient, limit of detection and relative standard deviation for lead were reported to be 0.5-950, 0.9988, 0.35 μg L-1 and 3.5%, respectively. For cadmium the above mentioned figure of merits were 0.3-980, 0.9969, 0.15 μg L-1 and 2.4%, respectively. The adsorption capacities for lead and cadmium were reported to be 10.28 and 10.38, while their imprinting factors were 5.89 and 6.36, respectively.In this work, paper spray (PS) is combined with atmospheric pressure photoionization-mass spectrometry (PS-APPI-MS) for the determination of non-polar and low polar compounds, such as the neutral per- and polyfluorinated alkyl substances (PFAS). The proposed PS-APPI-MS method has been developed for the analysis of fluorotelomer alcohols (FTOHs), fluoroctanesulfonamides (FOSAs) and fluorooctane sulfonamido-ethanols (FOSEs), using both negative ion mode and high-resolution mass spectrometry (HRMS). The most critical working parameters (i.e., UV-krypton lamp position, sample drying time, spray dopant solvent and spray voltage) have been evaluated to study both the ionization behaviour and ionization efficiency. The best results were achieved using dopant-assisted PS-APPI-HRMS with toluene as dopant solvent. The most intense ions observed in the mass spectra, [M‒H]‒ for FOSAs and [M+O2]‒• for FTOHs and FOSEs, were selected and proposed for fast screening and quantitative analysis of target compounds in waterproof impregnation sprays samples using internal standard calibration method and being able to detect down to μg L-1 levels. The satisfactory values of the method quality parameters (detection capability, repeatability, trueness and linearity) demonstrated the good performance of the PS-APPI-HRMS method and allowed the identification and quantitation of some FTOHs (62 FTOH, 7-Me-62 FTOH, 82 FTOH, 102 FTOH) and N-MeFOSE at mg L-1 in some of the waterproof impregnation spray products analyzed. This low-cost PS-APPI-HRMS method allows a fast screening, with minimum sample preparation, of non-polar and low polar compounds simultaneously, which can significantly improve the throughput on routine laboratories.
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