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Vulnerable and fast on-site diagnosis regarding SARS-CoV-2 using a gold nanoparticle-based high-throughput podium as well as CRISPR/Cas12-assisted RT-LAMP.
This understanding at the genetic level helps to define the relationship between dementia and autophagic dysfunction for developing the potential remedies for the treatment of dementia.
Poor nutritional effect of junk food induces injurious adversities to the liver and brain but still most of the developing nations survives on these diets to compensate for fast-paced lifestyle. Aim of the study is to infer the proteinconnections behind liver-brain axis and identify the role of these proteins in causing neurodegenerative disorders.

Chronic consumption of fructose and fat rich food works as a toxin in body and have the ability to cause negative metabolic shift. Recently a study was published in Annals of Internal Medicine (2019) citing the loss of vision and hearing in a 14-year-old boy whose diet was strictly restricted to fries and junk-food for almost a decade. check details This puts the entire body on insulin resistance and related co-morbidities and causes simultaneous damaging effects in liver as well brain. This work provides insights into liver-brain axis and explains how liver is involved in brain related disorders.

In this study transcriptomic data relating to chronic eating of junk-food waseases lie outside the brain and aiming them for drug discovery and design may be beneficial in future clinical studies. This study also discusses the connection between NAFLD (nonalcoholic fatty liver disease) and sAD (sporadic Alzheimer's disease) owing to liver-brain axis.
We strongly advocate that prolonged consumption of junk food is a major culprit in brain related disorders like Alzheimer's disease and propose that receptors for brain diseases lie outside the brain and aiming them for drug discovery and design may be beneficial in future clinical studies. This study also discusses the connection between NAFLD (nonalcoholic fatty liver disease) and sAD (sporadic Alzheimer's disease) owing to liver-brain axis.
In present days scenario of pandemic of COVID 19 the protective reflexes namely Sneeze and Cough have received great importance but not in terms of protection but in terms of spread of infection. The present review tries to bring out the correlation between the physiology of sneeze and cough taking into consideration the various receptors that initiate the two reflexes then correlating it with the formation of expelled droplets and the significance of various aspect of droplets that lead to the spread of infection.

For the compilation of the present review we searched the terms "Physiology of cough", "Physiology of sneeze", "droplets", "aerosols" and "Aerosols in COVID 19". The above-mentioned terms were extensively searched on pubmed, google scholar and google search engine and after reviewing the various available material the most significant research has been taken into consideration for this review.

Through this review we conclude that there are various factors that are responsible for the initiatiptors to produce the reflex outburst of air. As the flow of air during expiration is turbulent it causes damage to the Epithelial Lining Fluid present in the respiratory conduit and also gets admixed with the saliva in the oropharynx and oral cavity and mucus in the nose to form droplets of various sizes. Large droplets Settle close and are responsible for Droplet and Fomite transmission but the smaller droplets remain suspended in air and travel farther distances to cause Airborne transmission. The spread of droplet cloud in sneezing may range to 6m or more as compared to cough hence the concept of 1m to 2m of social distancing does not hold good if the patient is sneezing.The Coronavirus Disease 2019, a pandemic caused by novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is seriously affecting global health and the economy. As the vaccine development takes time, the current research is focused on repurposing FDA approved drugs against the viral target proteins. This review discusses the current understanding of SARS-CoV-2 virology, its target structural proteins (S- glycoprotein), non-structural proteins (3- chymotrypsin-like protease, papain-like protease, RNA-dependent RNA polymerase, and helicase) and accessory proteins, drug discovery strategies (drug repurposing, artificial intelligence, and high-throughput screening), and the current status of antiviral drug development.Since December 2019, there has been an increasing number of patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) around the world. As of March 2020, the World Health Organization declared a global pandemic. To our best knowledge, this is the first report of a patient with SARS-CoV-2 infection presenting with constrictive pericarditis, possibly from the COVID infection. She was presented after a week of fever, persistent dry cough, and diarrhea. She received a single dose of hydroxychloroquine 400 mg, Oseltamivir 75 mg every 12 hours, lopinavir/ritonavir (Kaletra) 400/100 mg every 12 hours, and levofloxacin 750 mg daily. After 24 hours, she was immediately transferred to the Intensive Care Unit (ICU) because of dyspnea and progressive respiratory failure with a drop of the O2 saturation to 70%. After a week of progress, her respiratory condition deteriorated again. She was re-admitted to the ICU and she expired. She died due to isolated constrictive pericarditis, most probably caused by SARS-CoV-2.
McCune-Albright Syndrome (MAS) is a genetic disorder with a triad of endocrine diseases, caféau-lait macules and fibrous dysplasias. Craniofacial fibrous dysplasia is a term that is used to describe the fibrous dysplasia which were localized at the craniofacial skeleton and it is common in MAS patients.

The objective of this review is to determine the involvement frequency of cranial and facial bones in the patients with MAS and CFD.

Articles in PubMed was searched with the following details "(mccune[Title/Abstract] OR albright[Title/Abstract]) OR ('craniofacial fibrous dysplasia'[MeSH Terms] OR ('craniofacial'[All Fields] AND 'fibrous'[All Fields] AND 'dysplasia'[All Fields]) OR 'craniofacial fibrous dysplasia'[All Fields])". The articles in which the authors did not stated the involved bones or did not add any radiographic images were excluded from the study.

26 cases in 25 articles which met the inclusion criteria was found. Among the 26 cases and our case, sphenoid and frontal bones were involved in 17 cases, parietal and occipital bones were involved in 15 cases, mandible and ethmoid bone was involved in 14 cases, maxilla-zygoma-temporal and palate was involved in 13, 11, 6 and 3 cases, respectively.
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