Notes

Rice Husk Silica Liquid Protects Pancreatic β Tissues via Streptozotocin-Induced Oxidative Injury.
Paraneoplastic syndromes occur in about 0.1% of patients affected by neoplastic diseases. In some types of tumors, such as Small Cell Lung Cancer (SCLC), Thymoma, and particular forms of Plasmacytoma, the association with Paraneoplastic Neurological Syndromes (PNS) is much more frequent. It seems that these syndromes are triggered by tumor production of factors normally expressed only by the individual's nervous system. The immune system stimulates an autoimmune response against these factors that induce neurological symptoms. Also, in light of the latest updates on the relationship between immunotherapy and PNS as well as of the introduction of first-line immunotherapy in SCLC, it seems that the use of immunotherapy in SCLC is associated with concomitant increase in autoimmune neurological syndromes.In this article, we report our experience at Istituto Nazionale Tumori of Milan with three patients affected by SCLC and PNS. Our experience seems to confirm that the oncological treatment scarcely impacts the paraneoplastic neurological deficits. Further research is needed to improve the treatment and recovery of patients affected by PNS.Awareness of COVID-19 infection risk and oscillation patterns ('waves') may affect older people's mental health. Empirical data from populations experiencing multiple waves of community outbreaks can inform guidance for maintaining mental health. This study aims to investigate the effects of COVID-19 infection risk and oscillations on depression among community-dwelling older people in Hong Kong.A rolling cross-sectional telephone survey method was used. Screening for depression risk was conducted among 8,163 older people (age ≥ 60) using the Patient Health Questionnaire-2 (PHQ-2) from February to August 2020. The relationships between PHQ-2, COVID-19 infection risk proxies - change in newly infected cases and effective reproductive number (Rt), and oscillations - stage of a 'wave' reported in the media, were analysed using correlation and regression.8.4% of survey respondents screened positive for depression risk. Being female (β = .08), having a pre-existing mental health issue (β = .21), change in newly infected cases (β = .05), and screening during the latency period before the media called out new waves (β = .03), contributed to higher depression risk (R2 = .06, all p less then .01).While depression risk does not appear alarming in this sample, our results highlight that older people are sensitive to reporting of infection, particularly among those with existing mental health needs. Future public health communication should balance awareness of infection risks with mental health protection.Dietary interventions are common but controversial treatments for autistic people. This study aims to understand the adoption of dietary interventions based on diffusion of innovations theory in the autism online community from four aspects popularity, adoption process, the influence of opinion leaders, and post-adoption feedback. Our data was extracted from a Chinese autism community named Baidu Tieba autism forum. We applied a mixed-method including four analytical approaches descriptive statistics for popularity analysis; machine learning models for automatic data classification and topic detection; social network analysis for exploring the influence of opinion leaders on the adoption phase; content analysis for revealing the family caregiver-reported feedback after adoption. Dietary interventions have become increasingly popular in the autism online community since 2018. Analysis of the adoption process revealed that family caregivers at different stages of adoption focused on different topics, and the number of interactions with opinion leaders had a significant effect on the highest level (p  less then  .001) and stage span (p  less then  .001) of health information adoption. According to findings from the feedback of family caregivers, the effects of dietary interventions varied from individuals with autism. Our study revealed the diffusion of unproven interventions, which is of great significance in promoting evidence-based practices.Compared with their younger counterparts, older adults are inclined to allocate more attentional resources to positive over negative materials. This age-related positivity effect has been reported in various experimental paradigms; however, studies have not investigated the attention stage at which it appears or its potential neural mechanism. Thus, we investigated the time and frequency domain dynamics of younger and older adults during emotional attention processes. We obtained electroencephalography oscillation and event-related potential data for 20 older and 20 younger participants while they performed an emotional dot-probe task. We focused our time and frequency domain dynamics analyses on the posterior regions as a key structure for facial emotion perception and the frontal regions as a crucial structure for cognitive control. In the time domain, older adults showed an initial attentional shift to happy-related stimuli, whereas their younger counterparts did not demonstrate emotional modulation, as reflected by the N2pc component. The time-frequency decomposition was analyzed for the N2pc time window. The results showed that compared with younger adults, older adults showed an increased alpha power for happy faces in the right-posterior regions. Moreover, a parallel pattern was seen in frontal theta activity. The current findings highlight how electrocortical activity of the brain might moderate the tendency to prioritize positive information among healthy older adults. The emergence of an age-related positivity effect may be related to frontal cognitive control processing. These findings provide insight into the prevention and treatment of unsuccessful aging, such as late-life depression and anxiety.
With the goal of informing culturally appropriate intervention strategies, the purpose of this qualitative study was to understand the Korean American immigrant women's (KAIW) perceptions of breast cancer risk and how their perceived risk, along with normative breast cancer prevention beliefs, shaped their attitudes toward mammography.

Semi-structured individual interviews were conducted with 30 Korean women in Los Angeles County, Los Angeles, California. Braun and Clarke's thematic analysis was used to code and analyze interview data.

Two major themes were identified (a) perceived risk of breast cancer and attitudes to prevention (e.g., worried and using all means of prevention) and (b) influences on attitudes to breast cancer prevention (e.g., family members and friends' cancer experiences).

Breast cancer prevention interventions for KAIW should target perceived breast cancer risk, social factors such as women's family roles and social networks, and health information evaluation skills.
Breast cancer prevention interventions for KAIW should target perceived breast cancer risk, social factors such as women's family roles and social networks, and health information evaluation skills.Marek disease (MD) is a viral disease characterized by the development of lymphoma in poultry. Although morphologic confirmation of lymphoma is used to diagnose MD, immunohistochemical detection of MD virus-EcoRI-Q (Meq), which is a viral protein that is expressed exclusively in MD tumor cells, would further improve the accuracy of diagnosis. We developed monoclonal antibodies (mAbs) that specifically detect Meq by immunohistochemistry (IHC) using formalin-fixed, paraffin-embedded (FFPE) sections. We evaluated the sensitivity and specificity of 14 mAbs that we produced, using FFPE samples of MDCC-MSB1 cells, MD tumor tissues, and tissues of uninfected chickens. Four different antigen retrieval conditions were investigated. Thirteen mAbs reacted with Meq in FFPE sections, but immunohistochemical reactivity and specificity varied depending on the mAb and antigen retrieval condition; heat-induced antigen retrieval (HIAR) was more effective at detecting Meq than the other tested conditions. HIAR pH 9 tended to increase immunoreactivity and decrease specificity. Of the 5 mAbs that immunoreacted strongly with Meq without nonspecific reactions under the optimal antigen retrieval conditions, 3 mAbs (1C1-121, 3A3-112, 5F7-82) did not produce background staining of tumor or non-tumor tissues; 2 mAbs (2C5-11, 4A5-54) produced background staining. The mAb 6B5-128 reacted moderately with Meq without nonspecific reactions and background staining. The remaining mAbs showed weak immunoreactivity or problematic nonspecific reactions. Our results suggest that some of our developed mAbs can be used in IHC to detect Meq in FFPE sections with high specificity, and that the use of IHC may greatly improve the diagnosis of MD.Flaxseed (FS) and sesame seed (SS) are traditional and functional foods in traditional Indian medicine for treating various disorders. The present study investigated the hepatoprotective effects of bioactive-fatty acids (FAs) from FS and SS against carbon tetrachloride (CCl4)-induced hepatic damage in rats. Pre and post-treatments for 28 consecutive days significantly increased the activities of in vivo antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD), and peroxidase (POX), whereas, lipid peroxidation (LPO) activity was markedly decreased in a dose-dependent manner in liver and kidneys. A significant reduction was observed in the hematological parameters like aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and total bilirubin in the serum of post-treated animals compared to the negative control. The results were confirmed histopathologically. The results suggested that the ω-3 and ω-6 FAs from flaxseed oil (FSO) and sesame seed oil (SSO), respectively, showed potential synergistic hepatoprotective and antioxidant effects that were mediated mainly by ω-3 and ω-6 FAs present in the respective seed oils.Do people accurately perceive their partner's humor style? The current study extends work on partner perception by examining accuracy and bias in people's perception of their partners' humor styles-a subjective, evaluative, and important factor in relationship satisfaction. We recruited 337 heterosexual couples (N = 674 individuals, Mage = 65.71 years, SD = 12.107) who completed self-reports and partner-reports of humor styles. Truth and Bias modeling revealed that, although bias varied across humor styles, participants consistently demonstrated accuracy in their judgments of their partner's humor styles. Bias forces were moderated by relationship satisfaction such that assumed similarity biases were stronger among those in particularly satisfying relationships.
To investigate how step counts relate to overall physical activity (PA) in able-bodied adults and stroke survivors in developing countries.

Sixty able-bodied adults (mean age 48.8 ± 11.7 years old) and 60 stroke survivors (mean age 56.7 ± 10.4 years old) were recruited in Benin (West-Africa). Step counts were collected for 7 consecutive days using the Garmin Forerunner 15 activity tracker. Then, participants completed the adapted French version of the International Physical Activity Questionnaire (IPAQ-AF) to report their PA over the same period. Spearman's rank correlation coefficients (ρ) were calculated between IPAQ-AF scores and the mean steps per day.

Very high correlations were observed between IPAQ-AF total scores and step counts, in able-bodied adults (ρ = 0.94;
 < 0.001), and in stroke survivors (ρ = 0.91;
 < 0.001). IPAQ-AF leisure-time presented negligible correlation with step counts in able-bodied adults. learn more No activity was reported in occupation and intense domains in stroke survivors.
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