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Graph and or chart Mix Network-Based Multimodal Mastering for Cold involving Running Discovery.
in English, Spanish INTRODUCCION Publicaciones recientes reportaron el alta temprana y bajos requerimientos de opioides para el control del dolor postoperatorio en la reparación mínimamente invasiva del pectus excavatum tras crioablación bilateral de nervios intercostales. Nuestro objetivo es describir nuestra experiencia inicial con esta técnica. MATERIAL Y METODOS Análisis retrospectivo de historias clínicas de pacientes sometidos a crioanalgesia toracoscópica bilateral durante la reparación mínimamente invasiva del pectus excavatum en nuestra institución desde septiembre de 2018 a marzo de 2019. TECNICA Se aplicó una criosonda a -70°C bajo visión toracoscópica durante 2 minutos del 3º al 7º espacio intercostal, de manera bilateral. El dolor postoperatorio fue evaluado con una Escala Visual Analógica. RESULTADOS Se incluyeron 21 pacientes, de los cuales el 90% era de sexo masculino con una edad media de 15,2 ± 4,29 años y un peso de 53,6 ± 15,33 kg. El índice de Haller promedio fue de 5,1 ± 2,97 y el índice de corrección de 37,6 ± 13,77%. El número promedio de implantes fue de 2,55 ± 0,74. La duración media de la crioanalgesia fue de 39,9 ± 21,1 minutos. Ninguno recibió anestesia peridural. El tiempo de internación postquirúrgico fue de 1,64 ± 0,73. La necesidad de rescate con opiáceos fue menor a 1 dosis en el 71,3%. La puntuación de dolor en los días postoperatorios 1, 3, 7 y 21 fue, en promedio, de 2,55; 2,01; 0,5 y 0,06, respectivamente. CONCLUSIONES El empleo de la crioanalgesia toracoscópica bilateral permitió el alta hospitalaria temprana y buen control del dolor postoperatorio en todos los casos, convirtiéndose en el método analgésico de elección en nuestra práctica clínica.This study aimed at visualizing relative relaxation time constant in soft tissue by using optical coherence elastography. We proposed a force vibration model as a theoretical base to express relaxation time constant (RTC) using axial gradient of periodic vibration phase captured by phase sensitive optical coherence tomography (PhS-OCT). Validation of the model had been accomplished by experiments with isotropic and double layered phantoms. A fresh chicken breast sample treated with focused ultrasound was prepared to test performance of the RTC-OCE in real tissue. All results were cross validated with indentation test and traditional strain based elastography. This study firstly utilized RTC mapping in 2D and 3D that covers the information of both elasticity and viscosity. The generated RTC mapping revealed the same mechanical difference internal sample which is correlated with conventional strain mapping. EdU RTC mapping is potentially to be served as new biomarker for disease diagnosis in the future. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.Organic electrode materials hold great potential for fabricating sustainable energy storage systems, however, the development of organic redox-active moieties for rechargeable aqueous zinc-ion batteries is still at an early stage. Here, we report a bio-inspired riboflavin-based aqueous zinc-ion battery utilizing an isoalloxazine ring as the redox center for the first time. This battery exhibits a high capacity of 145.5 mAh g-1 at 0.01 A g-1 and a long-life stability of 3000 cycles at 5 A g-1 . We demonstrate that isoalloxazine moieties are active centers for reversible zinc-ion storage by using optical and photoelectron spectroscopies as well as theoretical calculations. Through molecule-structure tailoring of riboflavin, the obtained alloxazine and lumazine molecules exhibit much higher theoretical capacities of 250.3 and 326.6 mAh g-1 , respectively. Our work offers an effective redox-active moiety for aqueous zinc batteries and will enrich the valuable material pool for electrode design. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.Microbially mediated decomposition of particulate organic carbon (POC) is a central component of the oceanic carbon cycle, controlling the flux of organic carbon from the surface ocean to the deep ocean. Yet, the specific microbial taxa responsible for POC decomposition and degradation in the deep ocean are still unknown. To target the active microbial lineages involved in these processes, 13 C-labeled particulate organic matter (POM) was used as a substrate to incubate particle-attached (PAM) and free-living microbial (FLM) assemblages from the epi- and bathypelagic zones of the New Britain Trench (NBT). By combining DNA stable-isotope probing and Illumina Miseq high-throughput sequencing of bacterial 16S rRNA gene, we identified 14 active bacterial taxonomic groups that implicated in the decomposition of 13 C-labeled POM at low and high pressures under the temperature of 15°C. Our results show that both PAM and FLM were able to decompose POC and assimilate the released DOC. However, similar bacterial taxa in both the PAM and FLM assemblages were involved in POC decomposition and DOC degradation, suggesting the decoupling between microbial lifestyles and ecological functions. Microbial decomposition of POC and degradation of DOC were accomplished primarily by particle-attached bacteria at atmospheric pressure and by free-living bacteria at high pressures. Overall, the POC degradation rates were higher at atmospheric pressure (0.1 MPa) than at high pressures (20 and 40 MPa) under 15°C. Our results provide direct evidence linking the specific particle-attached and free-living bacterial lineages to decomposition and degradation of diatomic detritus at low and high pressures and identified the potential mediators of POC fluxes in the epi- and bathypelagic zones. © 2020 The Authors. MicrobiologyOpen published by John Wiley & Sons Ltd.PURPOSE This prospective study aimed to investigate the effects of transobturator tape (TOT) procedure on patients with stress urinary incontinence (SUI) and their spouses' sexual function. MATERIAL AND METHODS A total of 157 patients with SUI who underwent TOT operation between January 2017 and May 2019 and their spouses were included. All patients enrolled filled out the Incontinence Impact Questionnaire (IIQ-7), the Urogenital Distress Inventory (UDI-6), the Female Sexual Function Index (FSFI), and patients' spouses filled out International Index of Erectile Function (IIEF-5) before surgery and 6 months after the surgery. RESULTS The mean value of IIQ-7 and UDI-6 questionnaires in the sixth month after the TOT surgery was lower than the mean scores of these questionnaires before surgery (P  less then  .001). The mean value of the FSFI score was 21.84 ± 1.76 before the surgery and 25.43 ± 1.84 in the sixth month after the surgery (P  less then  .001). There was a significant improvement in desire, arousal, lubrication, orgasm, satisfaction, and pain scores on the FSFI domains (P  less then  .001, less then .001, less then .001, less then .001, less then .001 and less then .05, respectively). The mean value of the IIEF-5 score of patients' spouses was 48.31 ± 5.23 before surgery and 57.87 ± 7.22 in the sixth month after the surgery (P  less then  .001). Significant improvement was observed in IIEF-5 score regarding sexual desire, intercourse satisfaction, and overall satisfaction domains (P = .012, .002, and .006, respectively). CONCLUSION TOT surgery significantly improves the sexual functions of both patients and their spouses. © 2020 John Wiley & Sons Australia, Ltd.Drug lag - delayed approval or reimbursement - is a major barrier to accessing cutting-edge drugs. Unlike approval lag, reimbursement lag is under-researched. We investigated the key determinants of reimbursement lag under Taiwan National Health Insurance (NHI), and compared this lag to those in the United Kingdom (UK), Canada, Australia, Japan, and South Korea. Using retrospective data on 190 new NHI-reimbursed drugs from 2007-2014, we studied reimbursement lag in Taiwan versus other countries, and investigated associated factors using generalized linear models (GLM). The median reimbursement lags during before ("first-generation") and after ("second-generation") NHI drug reimbursement scheme was re-organized in Taiwan were 378 and 458 days, respectively. The "first-generation" lag was shorter only than that in South Korea, while the "second-generation" lag only exceeded those of the UK and Japan. In GLM models, higher drug expenditure and the introduction of the "second-generation" NHI were two statistically significant parameters associated with reimbursement lag among antineoplastic and immunomodulating agents. For other drug classes, the reimbursement price proposed by pharmaceutical companies and use of price-volume agreements were two statistically significant parameters associated with longer reimbursement lags. The current reimbursement lag in Taiwan is longer than one year, but only longer than those of the UK and Japan. The determinants differ between drug categories. A specific review process for antineoplastic and immunomodulating drugs may expedite reimbursement. There is a clear need for systematic data collection and analysis to ascertain factors associated with reimbursement lag and thereby inform future policy-making. This article is protected by copyright. All rights reserved.AIMS Clinical trials exploring the effects of the combination of Continuous subcutaneous insulin infusion (CSII) and continuous glucose monitoring (CGM), as compared with Multiple Daily Injections (MDI) with traditional self-monitoring of blood glucose (SMBG), have shown relatively wide reductions of HbA1c. In those trials, the usual basal insulin for MDI is U-100 glargine; several trials have shown that degludec is associated with a substantially lower risk of nocturnal hypoglycemia in type 1 diabetes (T1DM). The aim of this cross-over trial was to investigate the efficacy of a combination of CGM and CSII versus an optimized degludec-based MDI regimen + SMBG in T1DM subjects in optimizing glucose control. MATERIAL & METHODS The trial included 28 individuals who underwent a 4-week run-in phase, then they were randomized 11 to 1) CSII+CGM followed by MDI + SMBG or 2) an MDI basal-bolus regimen followed by CSII+CGM. RESULTS In patients randomized to the CSII+CGM → MDI + SMBG, a significant reduction of HbA1c versus baseline was found at the end of the first phase (CSII+CGM) without significant variation on the following MDI + SMBG phase. In the arm randomized to the MDI + SMBG→CSII+CGM sequence, a significant improvement of HbA1c was observed in the first phase (MDI + SMBG) together with a further decrease in the following CSII+CGM phase. In the comparison of the two treatments with a mixed linear model, CSII+CGM was superior to MDI + SMBG with respect to change in HbA1c (p = 0.001). CONCLUSIONS This study suggests that CSII+CGM improves glycemic control without relevant safety issues in T1DM, in comparison with MDI + SMBG. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.One nucleotide substitution at residue 272 of HLA-B*15010101 results in a new allele, HLA-B*1556. © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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