Notes

[Thermal desorption sampling-gas chromatography-tandem mass spectrometry which has a carbonyl-iron powdered ingredients amalgamated it monolithic column regarding enrichment and also resolution of pyrethroid pesticide residues inside tea samples].
Oleanolic acid (OA), a ubiquitous pentacyclic oleanane-type triterpene isolated from edible and medicinal plants, exhibits a wide spectrum of pharmacological activities and tremendous therapeutic potential. However, the undesirable pharmacokinetic properties limit its application and development. Numerous researches on structural modifications of OA have been carried out to overcome this limitation and improve its pharmacokinetic and therapeutic properties. This review aims to compile and summarize the recent progresses in the medicinal chemistry of OA derivatives, especially on structure-activity relationship in the last few years (2010-2021). It gives insights into the rational design of bioactive derivatives from OA scaffold as promising therapeutic agents.A chemical investigation of the Chinese liverwort Chandonanthus birmensis Steph identified five undescribed cembrane-type diterpenoids, together with six known cembrane diterpenes, one fusicoccane-type diterpenoid, and a dolabellane-type diterpenoid. Their structures were established by comprehensive analysis of HRESIMS, NMR spectroscopic data, electronic circular dichroism (ECD) calculations and single-crystal X-ray diffraction analysis. Cytotoxicity tests of the isolated diterpenoids against five cancer cell lines (A2780, A549, H460, H460RT, and HeLa) revealed that several compounds showed moderate inhibitory effects with IC50 values ranging from 11.1 to 36.2 μM.The fruiting bodies of Ganoderma sinensis are used as food raw materials of marketed healthcare products. To gain an insight into the chemical and biological profling of G. sinensis, twenty-five compounds including eleven undescribed ones (ganodermasines A‒K) and fourteen known ones were isolated. Among them, ganodermasines A‒D are undescribed diketopiperazine alkaloids, ganodermasines E and F are alkaloids containing a pyridine. The structures of undescribed compounds were identified by spectroscopic, computational, and crystallographic methods. The results of acetylcholinesterase (AchE) inhibitory activity show that ganodermasines I and J could inhibit AchE with IC50 values of 26.05 and 20.40 μM, respectively. In addition, neurotrophic assay in PC-12 cells showed that (+)-ganodermasine E, (-)-ganodermasine E, and ganodermasine I could stimulate neurite outgrowth at 10 μM, while the other isolates are inactive. The present findings will lend a hand for further utilization of G. sinensis.The freeze-thaw vacuum method for conditioning pretreated sludge has been proved that it not only has greater dewatering efficiency but also is more ecologically friendly. In this paper, the experiment is improved to address shortcomings in previous freeze-thaw vacuum approach for sludge treatment. The spatio-temporal distribution relationship of distance-time-temperature is developed and divided into two stages by numerically fitting the temperature change of freezing tubes in the sludge. It is expected to guide the time control of large-scale frozen sludge in practical engineering applications to achieve optimal dewatering treatment. Furthermore, the performance of dehydration after the model test is evaluated on multi-scale settlement and mechanical properties (macroscopic perspective), mean particle size (mesoscopic perspective), and SEM microstructure (microscopic perspective). The results reveal that the improved sludge treatment method of alternating freeze-thaw vacuum procedures, using both prefabricated horizontal drains (PHDs) and prefabricated vertical drains (PVDs), substantially benefits the sludge dewatering and reduction. This method results in an unparalleled volume reduction of 63.51% and a water content reduction to 58.54%. Moreover, in-situ vane shearing strength of the sludge obtained from the improved test meets the strength requirement for the landfill final cover soil, demonstrating that the method is superior in improving mechanical properties.
Limited studies investigated the association of prenatal exposure to PM
and fetal growth measured by ultrasound with inconsistent results. No study evaluated the effect of PM
constituents on fetal growth in utero. We aimed to investigated whether prenatal exposure to PM
and its constituents was associated with fetal growth measured by ultrasound.

A total of 4319 eligible pregnant women in Peking University Birth Cohort in Tongzhou (PKUBC-T) were included in the study. Based on mothers' residential addresses, we estimated prenatal PM
concentrations with a satellite-based spatiotemporal model and PM
constituents concentrations with a modified Community Multiscale Air Quality model. Fetal growth parameters of abdominal circumference (AC), head circumference (HC), and femur length (FL) were measured by ultrasound and then estimated fetal weight (EFW) was calculated. We calculated sex and gestational age-specific fetal growth Z-score and then defined the corresponding fetal undergrowth. Generalized ey identified that prenatal exposure to PM2.5 or its constituents was associated with impaired fetal growth. The findings provided evidence that control measures for PM2.5 constituents should be implemented for further promoting fetal growth.Currently, there is an urgent need to develop functional nanomaterials for highly effective environmental remediation. However, the long-term effect of remedial materials upon their injection into contaminated aquifer has frequently been overlooked. Here, the remediation of Cr(VI) contaminated aquifer by reduced graphene oxide (rGO) supported nanoscale zero-valent iron (nZVI@rGO) was investigated from a long-term perspective. The performances of nZVI@rGO samples with different rGO loadings in the removal of aqueous Cr(VI) were evaluated in batch experiments. The electron transfer properties different nZVI@rGO samples were investigated by measuring their corrosive potentials using the steady-state Tafel polarization curves. The results show that the electron transfer efficiency between Cr(VI) and nZVI@rGO is enhanced owing to the large reactive conjugated structure of rGO. Besides, the surface passivation of nZVI is effectively retarded due to the uniform accommodation of Cr(III) precipitates on rGO. The structure and composition of nZVI@rGO before and after Cr(VI) removal were analyzed by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). The characterization results revealed that most Cr(VI) ions (∼90%) will be reduced to Cr(III) precipitates on nZVI@rGO as the passivation product. Accordingly, Cr(VI) ions tend to react more readily at less blocked regions on the surface of rGO, and a layer-by-layer passivation model on nZVI@rGO surface is proposed. Our results provide new insights into the mechanism underlying the long-term remediation of Cr(VI) contaminated aquifer using nZVI@rGO, which helps design new materials and approaches for practical in-situ remediation engineering.The synthesis of anatase TiO2 nanoparticles with controlled morphology and increased 001 facets exposed without the presence of fluorine-derived substances is a challenge. Herein, we report a highly effective approach to fabricate anatase TiO2 nanoplates with exposed 001 facets and their exploitation as robust photocatalytic materials for dye remediation. These materials were synthesized under controlled hydrolysis and condensation reactions, using titanium (IV) n-butoxide in an ethanolic solution, with acetic and sulfuric acids, by a solvothermal method at 190 °C with or without the presence of the non-ionic surfactant Triton® X-100 and then characterized. During TiO2 crystal synthesis, the effect of a non-ionic surfactant on the TiO2 particle growth was investigated. Our results demonstrate that the proposed method can synthesize pure and crystalline anatase TiO2 square nanoplates that form nanostructured spheres with high surface area, uniformly sized mesopores, and exposed 001 facets. The presence of non-ionic surfactant increased the exposed 001 facets percentage of the formed nanoplates from 69 to 80%, decreased the crystallite thickness, but unaffected its crystalline phase and band gap energy. The kinetic constants (Ka e Kb) for the synthesized TiO2 anatase nanoplates are considerably higher than the commercial TiO2 anatase constant (Kc). The synthesized photocatalysts show higher efficiency in the photocatalytic removal of methylene blue (MB) than commercial TiO2 (for t = 120 min).As a reference laboratory for measles and rubella surveillance in Lombardy, we evaluated the association between SARS-CoV-2 infection and measles-like syndromes, providing preliminary evidence for undetected early circulation of SARS-CoV-2. Overall, 435 samples from 156 cases were investigated. RNA from oropharyngeal swabs (N = 148) and urine (N = 141) was screened with four hemi-nested PCRs and molecular evidence for SARS-CoV-2 infection was found in 13 subjects. Two of the positive patients were from the pandemic period (2/12, 16.7%, March 2020-March 2021) and 11 were from the pre-pandemic period (11/44, 25%, August 2019-February 2020). Sera (N = 146) were tested for anti-SARS-CoV-2 IgG, IgM, and IgA antibodies. Five of the RNA-positive individuals also had detectable anti-SARS-CoV-2 antibodies. No strong evidence of infection was found in samples collected between August 2018 and July 2019 from 100 patients. The earliest sample with evidence of SARS-CoV-2 RNA was from September 12, 2019, and the positive pofs of early SARS-CoV-2 circulation.Fluoride (F-) is one of the essential elements found in soil and water released from geogenic sources and several anthropogenic activities. Fluoride causes fluorosis, dental and skeletal growth problems, teeth mottling, and neurological damage due to prolonged consumption, affecting millions worldwide. Adsorption is an extensively implemented technique in water and wastewater treatment for fluoride, with significant potential due to efficiency, cost-effectiveness, ease of operation, and reusability. This review highlights the current state of knowledge for fluoride adsorption using biochar-based materials and the limitations of biochar for fluoride-contaminated groundwater and industrial wastewater treatment. Biochar materials have shown significant adsorption capacities for fluoride under the influence of low pH, biochar dose, initial concentration, temperature, and co-existing ions. Modified biochar possesses various functional groups (-OH, -CC, -C-O, -CONH, -C-OH, X-OH), in which enhanced hydroxyl (-OH) groups onto the surface plays a significant role in fluoride adsorption via electrostatic attraction and ion exchange. Regeneration and reusability of biochar sorbents need to be performed to a greater extent to improve removal efficiency and reusability in field conditions. Furthermore, the present investigation identifies the limitations of biochar materials in treating fluoride-contaminated drinking groundwater and industrial effluents. see more The fluoride removal using biochar-based materials at an industrial scale for understanding the practical feasibility is yet to be documented. This review work recommend the feasibility of biochar-based materials in column studies for fluoride remediation in the future.
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