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BACKGROUND ST-segment elevation myocardial infarction (STEMI) remains a leading cause of morbidity and mortality around the world. In patients with STEMI undergoing primary percutaneous coronary intervention (PPCI), electrocardiographic measures of ST-segment resolution (STR) may give information about the myocardial perfusion and poor prognosis. OBJECTIVES To investigate the relation of endocan and galectin-3 levels with STR in STEMI patients. MATERIAL AND METHODS In this cross-sectional study, 98 consecutive patients undergoing PPCI for STEMI were enrolled. Synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) scores were recorded. Electrocardiograms were assessed at baseline and 60 min after PPCI. According to STR levels, patients undergoing PPCI (n = 98) were divided into complete STR group (≥70%, n = 53) and incomplete STR group ( less then 70%, n = 45). RESULTS Serum glucose, total cholesterol, low-density lipoprotein cholesterol, SYNTAX score, endocan and galectin-3 levels were significantly higher and ejection fraction was significantly lower in the incomplete STR ( less then 70%) group (p less then 0.05 for all). Body mass index (BMI) (p = 0.046) and galectin-3 (p = 0.037) were independently associated with the SYNTAX score. Endocan (p = 0.044) and galectin-3 (p = 0.017) were independent predictors of incomplete STR. CONCLUSIONS In patients with STEMI, the levels of endocan and galectin-3 may be helpful in identifying patients with a higher risk of insufficient myocardial perfusion and worse clinical outcome after PPCI.Relapsed high-risk neuroblastoma has few effective therapies currently available or in development. Cabozantinib is an Food and Drug Administration approved multitargeted tyrosine kinase inhibitor for select adult malignancies with preclinical data suggesting efficacy against neuroblastoma. A safe and tolerable dose has been identified for children, but its efficacy remains unknown. We describe four children with relapsed metastatic neuroblastoma treated with cabozantinib. All four patients had extended disease control (two complete responsesfor >12 months, 2 stable disease >6 months) with manageable predictable toxicities requiring dose reduction in two patients. We discuss the potential for the use of cabozantinib in neuroblastoma. © 2020 The Authors. Pediatric Blood & Cancer published by Wiley Periodicals LLC.Modern chemistry seems to be unlimited in molecular size and elemental composition. Metal-organic frameworks or biological macromolecules involve complex architectures and a large variety of elements. Yet a general and broadly applicable theoretical method to describe the structures and interactions of molecules beyond the 1000 atom size regime semi-quantitatively is not self evident. For this purpose, a generic force-field named GFN-FF is presented, which is completely newly developed to enable fast structure optimizations and molecular dynamic simulations for basically any chemical structure consisting of elements up to radon. The freely available computer program requires only starting coordinates and elemental composition as input from which fully automatically all potential energy terms are constructed. GFN-FF outperforms other force-fields in terms of generality and accuracy, approaching in many cases the performance of much more elaborate quantum mechanical methods. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.OBJECTIVES The development of biomarkers to guide treatment decisions is a major research focus in rheumatoid arthritis (RA). Patients with RA have elevated interleukin-6 (IL-6) levels; however, the utility of IL-6 as a predictor of treatment response is unclear. The objective of this study was to investigate, by post hoc analysis, whether baseline IL-6 levels could predict sarilumab treatment responses in two phase III studies. METHODS Serum IL-6 concentrations were measured in patients with RA prior to receiving sarilumab 200 mg (n = 148) or adalimumab 40 mg (n = 152) every two weeks (Q2W) (MONARCH, NCT02332590) or sarilumab 150 or 200 mg+methotrexate (n = 401 and n = 396, respectively) or placebo+methotrexate (n = 397) Q2W (MOBILITY, NCT01061736). Efficacy and patient-reported outcomes were compared between and within groups according to IL-6 tertile using linear and logistic regression. Givinostat RESULTS In MONARCH, patients with high baseline IL-6 (n = 100; all ≥3×upper limit of normal) had higher disease activity at baseline than those with low IL-6 (n = 100). The magnitude of clinical improvement over 24 weeks with sarilumab versus adalimumab was greater in patients with high baseline IL-6 than patients with low baseline IL-6. In MOBILITY, patients with high IL-6 (n = 398) had higher disease activity and joint damage at baseline than those with low IL-6 (n = 397), were more likely to have joint progression, and had less clinical improvement over 52 weeks' treatment with placebo+methotrexate compared with sarilumab 150/200 mg+methotrexate. Baseline IL-6 and C-reactive protein were both predictive of outcomes. Safety profiles were similar between defined IL-6 tertiles. CONCLUSION IL-6 may be a prognostic marker of disease progression and severity, and patients with high IL-6 may be likely to benefit from sarilumab compared with adalimumab or methotrexate. Prospective validation is warranted to confirm the results of these post hoc analyses. This article is protected by copyright. All rights reserved.. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Cervical cancer is the most common gynecological malignancy, with high incidence and mortality rates in China. The microRNA miR-485-5p has previously been reported to serve as a negative regulator of tumorigenesis in breast cancer and hepatocellular carcinoma, and miR-485-5p has been observed to be differentially expressed between cervical cancer and normal control tissue. Here, we confirmed that miR-485-5p expression is lower in cervical cancer than in adjacent normal tissue and proceeded to investigate the effects of miR-485 on tumor behavior in cervical cancer cell lines. We report that miR-485-5p transcription is decreased in HPV-infected cervical cancer tissue, and levels of miR-485 in clinical samples are positively correlated with the 5-year overall survival rate. The transwell assay showed that miR-485-5p inhibited cell invasion and migration but had no influence on apoptosis and cell proliferation. Using a luciferase reporter assay, we demonstrated that miR-485-5p partially abrogated cell migration and proliferation by targeting FLOT-1 mRNA.
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