Notes

Axial psoriatic arthritis along with ankylosing spondylitis: same or perhaps distinct? Any real-world study using emphasis on comorbidities.
Complications not related to persistent pain occurred in 103 patients (24%). Ninety-three percent of complications did not require readmission or reoperation (CDS I-II). Within 90days, 8% presented to an ED, 2% required readmission, and 2% required reoperation. Common complications were back pain > 6weeks postoperatively (26%), surgical site complications (7%), and ileus/prolonged constipation (3%). Risk factors for experiencing any complication were BMI ≥ 34 (OR 3.44) and Lenke 6 curve (OR 1.95).

One in four AIS patients experiences a complication not related to persistent pain after primary PSF, higher than rates published from self-reported registries. Obesity and Lenke 6 curve may increase risk. While most do not require readmission or surgery, 15% of patients have their postoperative course altered by complications.

III-retrospective cohort study.
III-retrospective cohort study.Atrial fibrillation (AF) tends to occur frequently in patients with thyroid disease, primarily hyperthyroidism. In hyperthyroidism, increased levels of thyroid hormones, via intra- and extranuclear mechanisms, have profound effects on cardiac electrophysiology. Hypothyroidism carries a lower risk for AF and is mainly associated with the overtreatment of hypothyroid patients. New-onset AF is frequently the only manifestation of thyroid disease, which renders screening for thyroid dysfunction in that scenario clinically useful. Managing thyroid disease and comorbid AF is essential. This includes thyroid hormones control along with conventional AF therapy. However, there are several open issues with this comorbid duo. The optimal management of thyroid disease and its impact on AF burden remains obscure. There is scanty information on clear-cut benefits for therapy of subclinical thyroid disease and screening of asymptomatic patients. Furthermore, the immunogenetic overlap between the autoantibodies in Graves' disease and AF genesis may lead to novel therapeutic implications. The objective of this review is to summarize the up-to-date epidemiology, pathogenesis, pathophysiology and management of interacting thyroid disease and AF.Avian pathogenic Escherichia coli (APEC) is responsible for colibacillosis in poultry. APEC remains a constant problem for the poultry industry, despite the use of antimicrobials and disinfectants in farms. The endemicity of APEC in poultry farms is associated with its biofilm-forming ability, which is further aggravated by various virulence factors and resistance to multiple drugs that help bacteria to thrive under different environmental conditions. To characterize APEC from affected broiler chickens and their environments, samples (n=114) from dead birds (heart, liver, lungs, and cloacal swab) and surrounding environments such as feeder, drinker, litter, PVC pipe, water tank wall, feed, and water were collected. The collected samples were subjected to microbial isolation using MacConkey Lactose agar (MLA) and Eosin Methylene Blue agar (EMB), which led to the isolation of 62 E. coli isolates. This was confirmed by uspA gene amplification and Vitek 2 Compact. These isolates were characterized using a set of five virulence genes (hlyF, ompT, iroN, iss, iutA), which yielded 47 (75.80%) isolates as APEC and the remaining as non-APEC. Furthermore, all the 62 isolates were subjected to microtiter plate assay for biofilm detection and the result showed that 36 (58.06%) isolates were able to form moderate to strong biofilms in Trypticase soy broth (TSB) at 72h of incubation. Of the 36 biofilm-producing isolates, 30 were APEC. Biofilm-related genes (crl, csgA, fimH, luxS, and papC) were also detected with higher prevalence among APEC isolates. Antimicrobial susceptibility test using Vitek 2 Compact revealed 43 (91.48%) of 47 APEC isolates as multiple drug resistant (MDR) and 8 (17.02%) as ESBL positive. This study reveals that APEC with biofilm formation ability is present in poultry farms. Further studies are needed to understand the role of biofilms in the pathogenesis and antimicrobial resistance of APEC.Sexting (sending, receiving, and forwarding nude, semi-nude, or sexually explicit content) entails risks for adolescents; therefore, it is important for parents to be able to communicate with their children about its implications. The goal of the present study was to identify parental characteristics that lead to dysfunctional communication (lower quality of communication) about sexting, on a sample of 427 parents (336 mothers and 91 fathers) of Israeli adolescents aged 10-18 years and to determine whether parents' perceived severity of sexting and the degree to which they perceive their adolescent to be susceptible to sexting function as mediating factors. Parents completed a set of questionnaires online. Findings indicated that authoritarian and permissive parenting styles were positively associated with dysfunctional parent-child communication about sexting. Authoritative style was inversely related to dysfunctional communication and was mediated by positive attitudes toward sex education. Additionally, authoritative parents were capable of assessing the severity of their children's sexting activities, and the degree to which their children were susceptible to engage in sexting. The quality of the discussion initiated by authoritative parents appears to have enabled them to be aware of adolescent behaviors and to adjust their communication about the inherent risks. Findings suggest that the perception of sexting as too risky diminishes parents' ability to conduct a high-quality discussion about it. In conclusion, research findings emphasize parents' role in mediation of the online experiences of their children and conducting a constructive discussions with them about sexting.Sexual orientation describes sexual interests, approaches, arousals, and attractions. People experience these interests and attractions in a number of contexts, including in-person sexuality, fantasy, and porn use, among others. The extent to which sexual orientation is divergent (branched) and/or overlapping (coincident) across these, however, is unclear. In the present study, a gender/sex and sexually diverse sample (N = 30; 15 gender/sex/ual minorities and 15 majorities) manipulated digital circles representing porn use, in-person sexuality, and fantasy on a tablet during in-person interviews. Participants used circle overlap to represent the degree of shared sexual interests across contexts and circle size to indicate the strength and/or number of sexual interests within contexts. Across multiple dimensions of sexual orientation (gender/sex, partner number, and action/behavior), we found evidence that sexual interests were both branched and coincident. These findings contribute to new understandings about the multifaceted nature of sexual orientations across contexts and provide a novel way to measure, conceptualize, and understand sexual orientation in context.Women are socialized to endorse femininity scripts mandating that they prioritize others' needs and engage in self-silencing behaviors. Further, Black women may also endorse the strong Black woman (SBW) ideal, by which they are expected to selflessly meet the needs of their family and community and, as such, may embrace self-silencing in their interpersonal relationships. In a sample of 597 Black undergraduate and graduate college women, we tested whether (1) self-silencing and SBW ideal endorsement would be independently, inversely associated with three dimensions of sexual assertiveness-communication assertiveness, refusal assertiveness, and pleasure-focused assertiveness; and (2) the association between self-silencing and sexual assertiveness would be stronger among Black women who endorse the SBW ideal. Correlational and regression analyses revealed that self-silencing was negatively linked to all dimensions of sexual assertiveness; SBW ideal endorsement was associated with lower levels of communication and pleasure-focused assertiveness. As expected, SBW ideal endorsement moderated the association between Black women's engagement in self-silencing and two dimensions of sexual assertiveness. Self-silencing was associated with less communication and pleasure-focused assertiveness regardless of their level of SBW endorsement. EUK 134 Findings highlight the complexities of Black women's desire to fulfill expectations to be strong, assertive, and/or compliant and silent. Interventions to promote Black women's sexual health should address sexual assertiveness and feminine silencing norms.
This study aims to examine the predictive role of obesity-type-related indexes and perioperative intraabdominal pressure measurements for early postoperative complications following bariatric surgery.

Sixty-seven female patients with obesity who underwent bariatric surgery (laparoscopic sleeve gastrectomy or gastric bypass) were included in this study. Obesity-related indexes (BMI, waist/hip ratio, and waist/height ratio) were calculated using patient data. Intraoperative hemodynamic measurements and intraabdominal pressure measurements were done at the beginning and at the end of the operation. Intraabdominal pressure measurements were done using both bladder port and trocar port. Patients were followed for early postoperative complications.

Among 67 patients included, 22 developed early postoperative complications (32.8%), mostly pulmonary (20.9%). Trans-trocar IAP measured at the beginning of the operation emerged as the single independent predictor of postoperative complications (OR, 40.3; p = 0.002). Based on ROC analysis, AUC for predicting complications was 0.955 (p < 0.01). Optimal cutoff point (≥ 14.5mmHg) was associated with 100% sensitivity and 82% specificity. In addition, there were weak but significant positive correlations between trans-trocar IAP-beginning and BMI (r = 0.443, p < 0.001), waist/hip ratio (r = 0.434, p < 0.001), and waist/height ratio (r = 0.539, p < 0.001).

Findings of this study suggest that a high baseline intraabdominal pressure predicts a higher risk for early postoperative complications following bariatric surgery. This information would help improve patient care. Further large studies are warranted.
Findings of this study suggest that a high baseline intraabdominal pressure predicts a higher risk for early postoperative complications following bariatric surgery. This information would help improve patient care. Further large studies are warranted.The inflammatory interleukin (IL)-23/IL-17 axis plays an important role in the pathogenesis of ankylosing spondylitis (AS), but with an unknown regulatory mechanism. This study aimed to investigate the role of endoplasmic reticulum (ER) stress and autophagy pathway in the expression of IL-23 in peripheral blood-derived macrophages in AS patients. Peripheral blood samples were obtained from 15 AS and 15 healthy control subjects. MACS was used to isolate monocytes from PBMCs. Then, M-CSF was used to differentiate monocytes to M2 macrophages. IFN-γ and/or LPS were used to activate macrophages and M2 polarization towards M1 macrophages. Thapsigargin was used to induce ER stress and 3-MA to inhibit autophagy. The purity of extracted monocytes and macrophage markers was evaluated by flow cytometry. mRNA expression of HLA-B and-B27, ER stress-related genes, autophagy-related genes, and IL-23p19 was performed using RT-qPCR. Soluble levels of IL-23p19 were measured using ELISA. Significant increase in mRNA expression of HLA-B, HLA-B27, BiP, XBP1, CHOP, and PERK mRNAs was observed in macrophages of AS patients before and after stimulation with IFN-γ and LPS.
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