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Computational Drug Repurposing with regard to Antituberculosis Treatments: Finding of Multi-Strain Inhibitors.
Extinction probabilities were greatest at low NDVI sites when rainfall declined. Within mesic systems, remotely sensed NDVI can identify areas of the landscape that act as drought refugia enabling landscape management to prioritise species conservation within these areas. The protection and persistence of refugia is crucial in ensuring landscapes and their species communities therein are resilient to a range of climate change scenarios.Metal-organic frameworks (MOFs) are emerging nanomaterials with widespread applications for their superior properties. However, the potential health and environmental risks of MOFs still need further understanding. In this work, we investigated the toxicity of a typical cobalt-based MOF (ZIF-67) with varied primary particle sizes (100, 200, 400, 700 and 1200 nm) to Photobacterium Phosphoreum T3 strain, a kind of luminescent bacteria. The luminescence inhibition rate of all ZIF-67 nanoparticles (NPs) reached 40 % and higher at the concentration of 5 mg/L, exhibiting strong toxicity. Combined cellular assays and gene expression analysis confirmed that the general bioactivity inhibition and oxidative damage were induced mainly by ZIF-67 NPs, rather than Co2+ released from the ZIF-67 NPs. Additionally, the toxicity of ZIF-67 NPs demonstrated an evident size-dependent effect. For ZIF-67 smaller than 400 nm, the toxicity increased with the particle size decreased, while the trend was not significant when the particle size was larger than 400 nm. A potential explanation for this phenomenon is the smaller NPs (100 and 200 nm) may enter the cytoplasm, accumulating in the cytoplasm and causing more severe toxicity. Furthermore, Co2+ released from the ZIF-67 NPs was not the primary contributor to the toxic effect of ZIF-67 NPs which was verified by the toxicity results and the variation of toxicity-related indicators. These findings provided insight into the better design and safer use of MOFs, and it also implied the potential environmental risk of the MOF's cannot be ignored, especially for the bioapplication.Microplastics (MPs) were continuously transported to wastewater treatment systems and accumulated in sludge constantly, potentially affecting systems function and co-occurrent contaminants fate. However, previous studies were based on acute exposure of MPs, which could not reflect the dynamics of MPs accumulation. Herein, this study firstly raised a more realistic method to evaluate the practical impacts of MPs on systems purification efficiency and antibiotic resistance genes (ARGs) fate. Continuous exposure of MPs did not pose negative effects on nutrients removal, but significantly changed the occurrence patterns of ARGs. ARGs abundances increased by 42.8 % and 54.3 % when exposed to millimeter-size MPs (mm-MPs) polyamide and polyethylene terephthalate, but increased by 31.3 % and 39.4 % to micron-size MPs (μm-MPs), respectively. Thus, mm-MPs posed severer effects on ARGs than μm-MPs. Further, mm-MPs surface properties were obviously altered after long-term exposure (higher specific surface area and O-containing species), which benefited microbes attachment. More importantly, more taxa linkages and changed topological properties (higher average degree and average weight) of co-occurrent network were observed in sludge with mm-MPs than with μm-MPs, as well as totally different potential host bacteria of ARGs. Rough surface of MPs and closer relations between ARGs and bacteria taxa contributed to the propagation of ARGs, which accounted for the observed higher ARGs abundances of mm-MPs. This study demonstrated that long-term accumulation of MPs in wastewater treatment systems affected ARGs fate, and mm-MPs caused severer risk due to their enrichment of ARGs. TIC10 The results would promote the understanding of MPs real environmental behavior and influences.The potential of industrial effluents from vitamin C (VC) production was assessed for agricultural applications by monitoring plant growth, soil properties, and microbial community structure. The results demonstrated that two types of effluents-residue after evaporation (RAE) and concentrated bacterial solution after ultrafiltration (CBS)-had positive effects on the yield and VC content of pak choi. The highest yield and VC content were achieved with a combined RAE-CBS treatment (55.82 % and 265.01 % increase, respectively). The soil fertility was also enhanced by the application of RAE and CBS. Nitrate nitrogen and organic carbon contents in the soil were positively correlated with the RAE addition, while ammonium nitrogen and available phosphorus were positively correlated with the CBS addition. The diversity of bulk and rhizosphere soil bacterial communities increased significantly after the addition of RAE-CBS. The abundance of Sphingomonas and Rhizobium significantly increased after the RAE-CBS treatment, which affected aromatic compound hydrolysis and nitrogen fixation positively. Changes in plant growth and soil fertility were closely related to the upregulation of functional gene expression related to C, N, and P cycling. RAE and CBS application exerted various positive synergistic effects on plant growth, soil fertility, and bacterial community structure. Consequently, the study results confirmed the potential of RAE and CBS application in agriculture. This study provides an innovative solution for utilizing VC industrial wastewater in agriculture in a resourceful and economically beneficial manner while alleviating the corresponding environmental burden.The widespread legalization of recreational marijuana raises growing concerns about exposure to secondhand marijuana smoke. An important location for marijuana smoking is the home, but few measurements of air pollutant concentrations in the home are available for a marijuana joint fully smoked in one of its rooms. We used research grade calibrated real-time continuous PM2.5 air monitors in controlled 5-hour experiments to measure fine particle concentrations in the 9 rooms of a detached, two-story, 4-bedroom home with either a tobacco cigarette or a marijuana joint fully smoked in the home's living room. The master bedroom's door was closed, and the other bedroom doors were open, as was the custom of occupants of this residence. In two experiments with a Marlboro tobacco cigarette smoked by a machine in the living room, the 5-hour mean PM2.5 concentrations in 9 rooms of the home were 15.2 μg/m3 (SD 5.6 μg/m3) and 15.0 μg/m3 (SD 3.7 μg/m3). In contrast, three experiments with pre-rolled marijuana joints smoked in the same manner in the living room produced 5-hour mean PM2.5 concentrations of 38.9 μg/m3 (SD 10.6 μg/m3), 79.8 μg/m3 (SD 25.7 μg/m3) and 80.7 μg/m3 (SD 28.8 μg/m3). In summary, the average secondhand PM2.5 concentrations from smoking a marijuana joint in the home were found to be 4.4 times as great as the secondhand PM2.5 concentrations from smoking a tobacco cigarette. Opening 3 windows by 12.7 cm reduced the high PM2.5 concentrations from marijuana smoking by 67 %, but the PM2.5 levels still exceeded those produced by tobacco smoking with the windows closed.During the two years following the first case of COVID-19 in the United Kingdom, cycles of social restrictions were imposed to control the spread of the virus. These measures curtailed social contact and halted commercial and recreational activities affecting levels of air pollutants. As society adapted, restrictions eased and pollution gradually returned to baseline levels. However, resurgence in COVID-19 cases from new variants created a protracted and challenging path back to 'normality'. In this study, we retrospectively look back at the two years of COVID-19 and its prevalent variants, and examine the government response and its impact on mobility and air pollution. Results from a peak detection algorithm show peak events in mobility and COVID-19 deaths during variants periods decreased significantly from the wildtype COVID-19, despite the high contagiousness of these variants. Pollution levels remained below baseline with periods of significant increase for O3, while NO2 levels remained depleted, likely as a result of reduced traffic congestion as home office schemes have been maintained. Our findings suggest mobility and pollution return to baseline levels as immunity to COVID-19 increases.During anaerobic digestion (AD) of liquid dairy manure, organic nitrogen converts to ammonia nitrogen (NH3-N) and subsequently escalates the NH3-N concentrations in manure. Among different available NH3-N removal processes treating anaerobically digested liquid dairy manure (ADLDM), vacuum thermal stripping is reported to be an effective technique. However, none of the studies have performed multi-parameter optimization, which is of utmost significance in maximizing process efficiency. In this study, critical operational parameters for vacuum thermal stripping of NH3-N from ADLDM were optimized and modeled for the first time via integrating grey relational analysis (GRA)-based Taguchi design, response surface methodology (RSM), and RSM-artificial neural network (ANN). The initial experimental trials conducted using the GRA coupled with Taguchi L16 orthogonal array revealed the order of influence of the process parameters on NH3-N removal as vacuum pressure (kPa) > temperature (°C) > treatment time (min) > mixing speed (rpm) > pH. The values of the first three most influential operating parameters were then further optimized and modeled using RSM and RSM-ANN models. Under the optimized conditions (temperature 69.6 °C, vacuum pressure 43.5 kPa, and treatment time 87.65 min), the NH3-N removal efficiency of 93.58 ± 0.59 % was experimentally observed and was in line with the RSM and RSM-ANN models' predicted values. While the RSM-ANN model showed a better prediction potential than did the RSM model when compared statistically. Moreover, the nutrient contents (nitrogen, N and sulfur, S) of the recovered NH3-N as ammonium sulfate ((NH4)2SO4) were in reasonable agreement with the market-available (NH4)2SO4 fertilizer. The results presented in this study provide important insights into improving the treatment process performance and will help design and operate future pilot- and full-scale vacuum thermal stripping processes in dairy farms.Seagrass meadows are important shallow coastal ecosystems due to their contribution to enhancing biodiversity, nutrient cycling, carbon burial, and sediment stabilisation, but the maintenance of their integrity has been threatened by several anthropogenic disturbances. Active restoration is considered a reliable strategy to enhance recovery of seagrass ecosystems, and decision making for correct seagrass restoration management requires relying on valuable information regarding the effectiveness of past restoration actions and experimental efforts. Previous experimental efforts and human-mediated active restoration actions of the slow growing seagrass Posidonia oceanica have been collated here by combining a literature systematic review and questionnaires consulting seagrass ecology experts. Overall, the poor consistency of the available information on P. oceanica restoration may be due to the wide portfolio of practices and methodologies used in different conditions, that supports the need of further field manipulative experiments in various environmental contexts to fill the identified knowledge gaps.
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