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This article focuses on the sampled-data synchronization issue for a class of complex dynamical networks (CDNs) subject to noisy sampling intervals and successive packet losses. The sampling intervals are subject to noisy perturbations, and categorical distribution is used to characterize the sampling errors of noisy sampling intervals. By means of the input delay approach, the CDN under consideration is first converted into a delay system with delayed input subject to dual randomness and probability distribution characteristic. To verify the probability distribution characteristic of the delayed input, a novel characterization method is proposed, which is not the same as that of some existing literature. Based on this, a unified framework is then established. By recurring to the techniques of stochastic analysis, a probability-distribution-dependent controller is designed to guarantee the mean-square exponential synchronization of the error dynamical network. Subsequently, a special model is considered where only the lower and upper bounds of delayed input are utilized. Finally, to verify the analysis results and testify the effectiveness and superiority of the designed synchronization algorithm, a numerical example and an example using Chua's circuit are given.Data in many practical problems are acquired according to decisions or actions made by users or experts to achieve specific goals. For instance, policies in the mind of biologists during the intervention process in genomics and metagenomics are often reflected in available data in these domains, or data in cyber-physical systems are often acquired according to actions/decisions made by experts/engineers for purposes, such as control or stabilization. Quantification of experts' policies through available data, which is also known as reward function learning, has been discussed extensively in the literature in the context of inverse reinforcement learning (IRL). However, most of the available techniques come short to deal with practical problems due to the following main reasons 1) lack of scalability arising from incapability or poor performance of existing techniques in dealing with large systems and 2) lack of reliability coming from the incapability of the existing techniques to properly learn the optimal reward function during the learning process. Toward this, in this brief, we propose a multifidelity Bayesian optimization (MFBO) framework that significantly scales the learning process of a wide range of existing IRL techniques. The proposed framework enables the incorporation of multiple approximators and efficiently takes their uncertainty and computational costs into account to balance exploration and exploitation during the learning process. The proposed framework's high performance is demonstrated through genomics, metagenomics, and sets of random simulated problems.In contrast with our everyday experience using brain circuits, it can take a prohibitively long time to train a computational system to produce the correct sequence of outputs in the presence of a series of inputs. This suggests that something important is missing in the way in which models are trying to reproduce basic cognitive functions. In this work, we introduce a new neuronal network architecture that is able to learn, in a single trial, an arbitrary long sequence of any known objects. The key point of the model is the explicit use of mechanisms and circuitry observed in the hippocampus, which allow the model to reach a level of efficiency and accuracy that, to the best of our knowledge, is not possible with abstract network implementations. By directly following the natural system's layout and circuitry, this type of implementation has the additional advantage that the results can be more easily compared to the experimental data, allowing a deeper and more direct understanding of the mechanisms underlying cognitive functions and dysfunctions and opening the way to a new generation of learning architectures.Sparse Bayesian learning (SBL) is a popular machine learning approach with a superior generalization capability due to the sparsity of its adopted model. However, it entails a matrix inversion at each iteration, hindering its practical applications with large-scale data sets. To overcome this bottleneck, we propose an efficient SBL algorithm with O(n²) computational complexity per iteration based on a Gaussian-scale mixture prior model. By specifying two different hyperpriors, the proposed efficient SBL algorithm can meet two different requirements, such as high efficiency and high sparsity. A surrogate function is introduced herein to approximate the posterior density of model parameters and thereby to avoid matrix inversions. Using a data-dependent term, a joint cost function with separate penalty terms is reformulated in a joint space of model parameters and hyperparameters. The resulting nonconvex optimization problem is solved using a block coordinate descent method in a majorization-minimization framework. Finally, the results of extensive experiments for sparse signal recovery and sparse image reconstruction on benchmark problems are elaborated to substantiate the effectiveness and superiority of the proposed approach in terms of computational time and estimation error.In deep reinforcement learning, off-policy data help reduce on-policy interaction with the environment, and the trust region policy optimization (TRPO) method is efficient to stabilize the policy optimization procedure. In this article, we propose an off-policy TRPO method, off-policy TRPO, which exploits both on- and off-policy data and guarantees the monotonic improvement of policies. A surrogate objective function is developed to use both on- and off-policy data and keep the monotonic improvement of policies. We then optimize this surrogate objective function by approximately solving a constrained optimization problem under arbitrary parameterization and finite samples. We conduct experiments on representative continuous control tasks from OpenAI Gym and MuJoCo. The results show that the proposed off-policy TRPO achieves better performance in the majority of continuous control tasks compared with other trust region policy-based methods using off-policy data.Sleep posture, as a crucial index for sleep quality assessment, has been widely studied in sleep analysis. In this paper, an unobtrusive smart mat system based on a dense flexible sensor array and printed electrodes along with an algorithmic framework for sleep posture recognition is proposed. With the dense flexible sensor array, the system offers a comfortable and high-resolution solution for long-term pressure sensing. Meanwhile, compared to other methods, it reduces production costs and computational complexity with a smaller area of the mat and improves portability with fewer sensors. To distinguish the sleep posture, the algorithmic framework that includes preprocessing and Deep Residual Networks (ResNet) is developed. With the ResNet, the proposed system can omit the complex hand-crafted feature extraction process and provide compelling performance. The feasibility and reliability of the proposed system were evaluated on seventeen subjects. Experimental results exhibit that the accuracy of the short-term test is up to 95.08% and the overnight sleep study is up to 86.35% for four categories (supine, prone, right, and left) classification, which outperform the most of state-of-the-art studies. With the promising results, the proposed system showed great potential in applications like sleep studies, prevention of pressure ulcers, etc.DNase I hypersensitive sites (DHSs) have proven to be tightly associated with cis-regulatory elements, commonly indicating specific function on the chromatin structure. Thus, identifying DHSs plays a fundamental role in decoding gene regulatory behavior. While traditional experimental methods turn to be time-consuming and expensive for genome-wide exploration, computational techniques promise to be a practical approach to discovering and analyzing regulatory factors. Conteltinib In this study, we applied an efficient model that could take care of both performance and speed. Our predictor, CEPZ, greatly improved a Matthews correlation coefficient and accuracy of 0.7740 and 0.9113 respectively, far more competitive than any predictor ever. This result suggests that it may become a useful tool for DHSs research in the human and other complex genomes. Our research was anchored on the properties of dinucleotides and we identified several dinucleotides with significant differences in the distribution of DHS and non-DHS samples, which are likely to have a special meaning in the chromatin structure. The datasets, feature sets and the relevant algorithm are available at https//github.com/YanZheng-16/CEPZ_DHS/.An enhancer is a short region of DNA with the ability to recruit transcription factors and their complexes, thus increasing the likelihood of the transcription possibility. Considering the importance of enhancers, the enhancer identification was popular in computational biology. In this paper, we propose a two-layer enhancer predictor, called iEnhancer-KL. Kullback-Leibler (KL) divergence is taken into consideration to improve feature extraction method PSTNP. Furthermore, LASSO is used to reduce the dimension of features to get better prediction performance. Finally, the selected features are tested on several machine learning models to find the best model with great performance. The rigorous cross-validations have indicated that our proposed predictor is remarkably superior to the existing state-of-the-art methods with an accuracy of 84.23% and the MCC of 0.6849 for identifying enhancer. Our code and results can be freely download from https//github.com/Not-so-middle/iEnhancer-KL.git.Natural language moment localization aims at localizing video clips according to a natural language description. The key to this challenging task lies in modeling the relationship between verbal descriptions and visual contents. Existing approaches often sample a number of clips from the video, and individually determine how each of them is related to the query sentence. However, this strategy can fail dramatically, in particular when the query sentence refers to some visual elements that appear outside of, or even are distant from, the target clip. In this paper, we address this issue by designing an Interaction-Integrated Network (I2N), which contains a few Interaction-Integrated Cells (I2Cs). The idea lies in the observation that the query sentence not only provides a description to the video clip, but also contains semantic cues on the structure of the entire video. Based on this, I2Cs go one step beyond modeling short-term contexts in the time domain by encoding long-term video content into every frame feature. By stacking a few I2Cs, the obtained network, I2N, enjoys an improved ability of inference, brought by both (I) multi-level correspondence between vision and language and (II) more accurate cross-modal alignment. When evaluated on a challenging video moment localization dataset named DiDeMo, I2N outperforms the state-of-the-art approach by a clear margin of 1.98%. On other two challenging datasets, Charades-STA and TACoS, I2N also reports competitive performance.
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