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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are often described by their focus on practical aspects of study design that include the recruitment process and consent, adhering and the use of standard equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized a variety of investigators and included participants from different geographic areas. This type of heterogeneity which is vital for pragmatic trials to be valid and lessen the chance of bias is also essential. However excessive heterogeneity could cause problems with the design of the trial.

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Pragmatic trials aim to mimic real-world situations and have the highest external validity. Usually, they are requested by practitioners and policymakers to inform their decisions. They are also a good way to identify the causal relationship between an intervention and its results. They should not, however, be used to replace explanatory studies.

The idea of pragmatism is controversial and there are doubts regarding whether pragmatic trials could replace explanatory tests or if they are a complement to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which prove a physiological or clinical hypothesis and pragmatic trials that inform the policy and practice of. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool attempted to define the traits of a practical study which includes recruitment, design, delivery of the intervention and its follow-up.

The number of pragmatic trials is growing. 프라그마틱 체험 using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatism. It is important to keep in mind that the majority of studies were conducted in primary-care settings.

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