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Gut microbiota dependent trimethylamine N-oxide exacerbates angiotensin II-induced high blood pressure.
m (80.44 ± 11.10) (t = -6.78, p = 0.000; t = -5.50, p = 0.000, respectively). The analysis indicated blood pressure and pulse readings were positively correlated with arm thickness but not correlated with the arm skinfold thickness or the thickness of the clothing. CONCLUSION The study revealed that constricting rolled-up sleeves and the thickness of the circumference of the arm were factors that produced higher systolic and diastolic blood pressure and pulse readings. HYPOTHESIS Aromatic organoarsenicals are heavily used as poultry feed additives, and the application of manure containing these compounds could release toxic inorganic arsenic into the environment. Bimetal ferrites are recognized as promising sorbents in removal of organoarsenicals with formation of FeOAs complexes, and their high saturation magnetization also allows easy sorbent separation. EXPERIMENTS Herein, a flower-like CoFe2O4 sorbent was synthesized through an environmental-friendly process. FINDINGS The flower-like CoFe2O4 particles have abundant mesopores and a large specific surface area of 48.4 m2/g. At an equilibrium concentration of 80 μmol/L, the sorption capacities towards p-arsanilic acid (p-ASA), roxarsone (ROX), 4-hydroxyphenylarsonic acid (4-HPAA), 2-aminophenylarsonic acid (2-APAA), phenylarsonic acid (PAA), and 2-nitrophenylarsonic acid (2-NPAA) were 38.1, 45.7, 38.7, 39.3, 33.0, and 32.8 mg/g, respectively. Langmuir model and pseudo-second-order kinetics could well fit the sorption isotherms and rates. The sorption performance was better under acidic conditions due to enhanced electrostatic attraction. Humic acid (HA) and PO43- inhibited the sorption through competing for sorption sites, while Fe3+ promoted sorption due to formation of additional FeOAs complexes on sorbent surface. LY450139 chemical structure The experimental observations, spectroscopic insights, and density functional theory (DFT) calculations consistently indicate that the sorption of aromatic organoarsenicals on the flower-like CoFe2O4 particles occurs mainly through formation of inner-sphere complexes. The flower-like CoFe2O4 could be regenerated and reused over multiple cycles. The high sorption capacities, together with its magnetic property, make the flower-like CoFe2O4 an attractive sorbent for removing aromatic organoarsenicals from wastewater. OBJECTIVES The tumor secretome deconvolution is a promising strategy to identify diagnostic and prognostic biomarkers. Here, transcriptomic-based secretome analysis was performed aiming to discover laryngeal squamous cell carcinomas (LSCC) biomarkers from potentially secreted proteins (PSPs). MATERIAL AND METHODS The tumor expression profile (35 LSCC biopsies compared with surrounding normal tissues - SN) revealed 589 overexpressed genes. This gene list was used for secretome analysis based on laryngeal tumors and related secretome databases. RESULTS Forty-nine (Laryngeal tumor secretome database) and 50 (Human Protein Atlas and Cancer Secretome Database) PSPs presented an association with worse overall survival. Specifically, DSG2 overexpression was strongly correlated with poor survival and distant metastasis. DSG2 increased expression was confirmed in the LSCC dataset (LSCC = 111; SN = 12) from TCGA. A significant association between shorter survival and DSG2 overexpression was also detected. In an independent cohort of cases, we analyzed and confirmed high protein levels of DSG2 in plasma from LSCC patients. CONCLUSION A set of PSPs including the circulating DSG2, were associated with shorter overall survival in LSCC. DSG2 overexpression was also correlated with distant metastasis. The high plasmatic protein levels of DSG2 suggest its potential to be tested in liquid biopsies and applied as prognostic biomarker of LSCC. STUDY OBJECTIVE To assess how the addition of a Pediatric and Adolescent Gynecologist (PAG) in an area where one has not previously been available impacts the use of long acting reversible contraceptive (LARC) among girls age 13-24. DESIGN Retrospective Chart Review SETTING Academic practice including 12 general practice OBGYNs (GP) and one PAG, and Title X clinics in three neighboring counties in West Virginia. PARTICIPANTS Patients receiving an intrauterine device (IUD) or implant during 2010-2016. INTERVENTIONS Subject charts were reviewed for age and date at insertion, provider (GP, PAG and Title X), device type, parity, discontinuation and sequential LARC placement. MAIN OUTCOME MEASURES Frequencies of LARC and RR with 95% confidence interval were calculated for the 13-17 and 18-24 year age groups and compared between provider type. RESULTS Frequency of LARC increased over time for all providers for subjects 13-24; the PAG had the highest frequency of LARC among age 13-17. The RR for IUD provision for the PAG provider among 13-17 year olds was 3.1 and 32.5 times greater compared to GP and Title X (p less then 0.001). Title X providers were 2.9 (2.27, 3.79) and 2.8 (2.06, 3.81) times more likely to provide implants to patients age 13-17 compared to PAG and GP, respectfully (p less then 0.001). CONCLUSIONS A PAG provider can have a positive impact on LARC uptake among adolescents in a community where this specialist has not previously been available. This is most noted among 13-17 year old patients receiving IUDs. STUDY OBJECTIVE Data regarding trial of labor after cesarean delivery (TOLAC) among young women are limited. link2 The aim of this study was to assess the TOLAC success rate and its related factors among adolescents who had never delivered vaginally. link3 DESIGN A multicenter retrospective cohort study of all adolescent women aged ≤21 years with a history of one previous cesarean delivery, who delivered in two tertiary medical centers during 2007-2019. Women were allocated to two groups 1) women who underwent TOLAC 2) women who had a repeat cesarean delivery with no trial of labor. Maternal and neonatal outcomes were compared between the two groups. In addition, perinatal outcomes were compared between women with successful and unsuccessful TOLAC. RESULTS The study cohort included 167 women who had a previous caesarean delivery, 117 underwent TOLAC and 50 underwent a repeat cesarean delivery with no trial of labor. Neonatal birth weight (median 2937 vs. 3170, p=0.03) and gestational age at delivery (median 38 weeks vs. ith a relatively high success rate. Adolescents in the United States are too often involved in relationships characterized by coercion and violence. An emerging body of research suggests that dating violence is linked with other health risks in adolescent relationships, particularly sexual risk behavior. The confluence of risks conferred by dating violence and sexual risk behavior are particularly acute for adolescent girls. Adolescent gynecology providers need to understand the nature of dating violence in adolescence and the ways in which dating violence and sexual risk behavior are mutually influential. This article reviews the literature on the links between dating violence and sexual risk in adolescent girls' relationships. The prevalence, risk factors, and consequences of dating violence in adolescence are discussed, followed by a review of the research linking dating violence and sexual risk, with a focus on common mechanisms underlying these relationship risk behaviors. The review concludes with implications for screening, prevention, intervention, and future directions for research. STUDY OBJECTIVE Occurrence and characteristics of contraception discussions with adolescents are unexplored. Our study sought to address this gap using transcripts of audiotaped healthcare visits. DESIGN, SETTING, AND PARTICIPANTS This study was a secondary analysis of 153 transcripts of medical visits with female adolescents with asthma. Medical visits took place among four outpatient clinics in North Carolina. MAIN OUTCOME MEASURE(S) Transcripts were reviewed for occurrence and characteristics of contraception discussions. Demographics were collected from adolescent interviews, caregiver questionnaires, and provider questionnaires. RESULTS Contraception was mentioned in 3% (n=5) of office visits. Conversations about contraception included the topics of contraception efficacy (20%), contraception side effects (60%), contraception adherence (20%) and adolescent sexual health (20%). No conversations included the topics of contraception indication or alternative methods. CONCLUSIONS Conversations about contraception occurred infrequently. When conversations did occur, the topics they covered lacked alignment with guideline recommendations. INTRODUCTION Sexually transmitted infections (STI) significantly impact the health of sexually active people, especially young people, and can cause sexual dysfunction, infertility, increased transmission of HIV, low self-esteem, and death. METHODS We reviewed the medical records of a cross section of users of a public health services center and verified the prevalence of STI and its associated predictors for male and female individuals aged 13-24 years in an interior county of southern Brazil. RESULTS The records of 1,703 adolescents and young adults, stratified by age (13-18 and 19-24 years respectively) and sex, admitted between April 1, 2012 and March 31, 2017, were reviewed in this retrospective study. Epidemiological, clinical, and laboratory data of medical records were analyzed using the chi-square test and odds ratio, with confidence interval of 95% by the Stata® 9.0 program. During the study period, a total of 3,448 patients were attended, and of these, 1,703 (49.39%) were aged 13-24 years, with 86.disease risk and minimizing costs and damages caused by the infections. Bifunctional catalyst Fe/Fe3C@C with magnetism was successfully prepared by sol-gel method and proved to degrade methyl orange with high efficiency under microwave irradiation. The Fe/Fe3C@C catalysts calcined at 500 °C, 600 °C, 700 °C were intensively characterized and compared in their crystalline structure, porosity, morphology and dielectric property. The results imply a phase and structure transformation in the materials as the calcination temperature increased. Fe/Fe3C@C-700 exhibited a core-shell structure and an apparent Fe3C phase. In addition, Fe/Fe3C@C-700 demonstrated excellent dielectric property as a microwave absorber than Fe/Fe3C@C-500 and Fe/Fe3C@C-600. At the same time, it gave a 100 % removal rate in 30 s for the degradation of methyl orange under microwave irradiation, outperformed the Fe/Fe3C@C-500 and Fe/Fe3C@C-600 and most other reported catalysts in similar studies. The possible mechanism of the methyl orange degradation should be ascribed to the in situ generation of •OH and O2•- active species over the Fe/Fe3C@C catalyst. The excellent microwave absorbing property of Fe/Fe3C@C-700 could also boost its catalytic activity and play a critical role during the super-fast microwave-assisted degradation process. The findings in this study could be informative for the development of a continuous process of dye wastewater treatment for industrial implementation. Bayesian accounts of perception, in particular predictive coding models, argue perception results from the integration of 'top-down' signals coding the predicted state of the world with 'bottom-up' information derived from the senses. This integration is biased towards predictions or sensory evidence according to their relative precision. Recent theoretical accounts of autism suggest that several characteristics of the condition could result from atypically imprecise top-down, or atypically precise bottom-up, signals, leading to a bias towards sensory evidence. Whether the integration of these signals is intact in autism, however, has not been tested. Here, we used hierarchical frequency tagging, an EEG paradigm that allows the independent tagging of top-down and bottom-up signals as well as their integration, to assess the relationship between autistic traits and these signals in 25 human participants (13 females, 12 males). We show that autistic traits were selectively associated with atypical precision-weighted integration of top-down and bottom-up signals.
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