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Paying off hepatitis C virus using immediate antiviral brokers reduces cardiovascular events in people with prediabetes. Comments in order to Sasso as well as co-workers.
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© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.The presence of regional metastasis is a predictor of worse survival in thick melanoma1 and is currently an indication for adjuvant therapy. Few studies have analyzed the prognostic role of clinical and pathologic variables in thick melanoma without metastatic lymph node involvement2-4 . The aim of this study was to identify them. This article is protected by copyright. All rights reserved.The most common denominator of many of the neurodegenerative diseases is the badly folded protein accumulation resulting in the formation of insoluble protein deposits located in different parts of the organism, causing cell death and tissue degeneration. Dendritic systems have turned out to be a promising new therapeutic approach for the treatment of these diseases due to their ability to modulate the folding of these proteins. In this perspective, and focused on Type 2 Diabetes (T2D) characterized by the presence of deposits containing the amyloidogenic islet amyloid polypeptide (IAPP), we present how different topologies of cationic carbosilane dendrimers inhibit the deposit formation in pancreatic islets isolated from Tg-hIAPP mice. Also, the results obtained by the modification of dendritic carbosilane wedges with a chemical chaperone 4-phenyl butyric acid (4-PBA) at the focal point, confirmed their promising potential as anti-amyloid agents with a concentration efficiency five orders of magnitude lower than that observed for the free 4-PBA in their therapeutic action. Computational studies, that determine at the atomic level the main interaction between IAPP and dendrimers, supported the experimental work. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.In December 2019, several novel coronavirus infections were firstly reported in Wuhan, Hubei Province in China, and the outbreak is quickly expanding locally and globally. World Health Organization (World Health Organization, 2020a) announced the coronavirus epidemic as an "International Public Health Emergency of International Concern (PHEIC)" on January 30, 2020. This article is protected by copyright. All rights reserved.Despite calls for increased investment in nursing, there is a global shortfall of 9 million nurses and midwives needed to deliver and sustain universal health coverage. The Nursing Now campaign run in collaboration with the World Health Organization and the International Council of Nurses has the laudable aim of raising the status and profile of nursing worldwide. However, nursing and midwifery are essentially female-dominated professions and men in most parts of the world comprise around 10% of the nursing workforce. If nursing is to truly reflect the makeup of the general population and be more inclusive and diversified it needs to attract more men. Efforts to address this include recruitment drives, positive rebranding of nursing as gender-neutral, pre-school education and outreach initiatives, and unconscious bias training. However, there is an urgent need to address the under-representation of men in nursing and explore the impact of a more gender balanced workforce. This article is protected by copyright. All rights reserved.Renal medullary carcinoma (RMC) is a rare, aggressive disease that predominantly afflicts individuals of African or Mediterranean descent with sickle cell trait. RMC comprises 1% of all renal cell carcinoma diagnoses with a median overall survival of 13 months. Patients are typically young (median age-22) and male (malefemale ratio of 21) and tumors are characterized by complete loss of expression of the SMARCB1 tumor suppressor protein. Due to the low incidence of RMC and the disease's aggressiveness, treatment decisions are often based on case reports. Thus, it is critical to develop preclinical models of RMC to better understand the pathogenesis of this disease and to identify effective forms of therapy. Two novel cell line models, UOK353 and UOK360, were derived from primary RMCs that both demonstrated the characteristic SMARCB1 loss. Both cell lines overexpressed EZH2 and other members of the polycomb repressive complex and EZH2 inhibition in RMC tumor spheroids resulted in decreased viability. High throughput drug screening of both cell lines revealed several additional candidate compounds, including bortezomib that had both in vitro and in vivo antitumor activity. The activity of bortezomib was shown to be partially dependent on increased oxidative stress as addition of the N-acetyl cysteine antioxidant reduced the effect on cell proliferation. Combining bortezomib and cisplatin further decreased cell viability both in vitro and in vivo that single agent bortezomib treatment. The UOK353 and UOK360 cell lines represent novel preclinical models for the development of effective forms of therapy for RMC patients. buy Panobinostat © 2020 The Authors. buy Panobinostat Genes, Chromosomes & Cancer published by Wiley Periodicals, Inc.From a large medical center in Wuhan, the epicenter of the 2019 novel coronavirus disease (COVID-19), we report clinical features and prognosis for three women diagnosed with COVID-19 after gynecologic oncology surgery and hospitalized in January 2020. The incidence of COVID-19 was 0.77% (3 of 389) of total hospitalizations and 1.59% (3 of 189) of patients undergoing surgeries in the ward. The infection of severe acute respiratory syndrome coronavirus 2 may be related to the older age, comorbidities, malignant tumor, and surgery in gynecologic hospitalizations. By February 20, 2020, only two of the three patients had met the clinical discharge criteria. Given the long and uncertain incubation period of COVID-19, screening for the virus infection should be carried out for all patients, both preoperatively and postoperatively. Postponement of scheduled gynecologic surgery for patients in the epidemic area should be considered. © AlphaMed Press 2020.In the last months of 2018 a number of reports concerning healthcare leadership in England were published. In October the NHS Leadership Academy published the findings of a survey of Chief Executives which explored their views of the attractions and barriers to clinicians becoming chief executives (NHS Providers/NHS Leadership Academy, 2018). This article is protected by copyright. All rights reserved.
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