Notes

Intrusive Lobular Breast Cancer: Data to compliment Surgical Decisions.
Balloon angioplasty for the treatment of femoropopliteal lesions is often complicated by postangioplasty dissections. While dissections are known to affect patency and reintervention after balloon angioplasty, the association between dissections and major adverse limb event (MALE) after drug-coated balloon (DCB) angioplasty remains uncertain. Thus, the postangioplasty dissection and bailout stenting patterns were investigated.

This was a single-center retrospective study enrolling patients with de novo femoropopliteal lesions treated with DCB with/without stenting. Postangioplasty target vessel dissection was graded based to the coronary artery classification grades A-F, with grade C-F considered "severe." Cox regression analysis was performed to examine the association of dissection severity with outcomes during 2-year follow up, among nonstented cases.

In 85.3% of the cases (N=203/238) a postangioplasty dissection was observed. The average dissection length was 55.57 mm (SD 36.71 mm), with 1 dissectio=0.905) during follow-up were similar between the 2 groups.

This study indicated that nonstented moderate and severe postangioplasty dissections after DCB angioplasty were associated with higher risk for MALE. Future studies are needed to validate our results and determine other dissection characteristics (eg, total dissection length, lumen area, total number of dissections) that may affect the efficacy of DCB.
This study indicated that nonstented moderate and severe postangioplasty dissections after DCB angioplasty were associated with higher risk for MALE. Future studies are needed to validate our results and determine other dissection characteristics (eg, total dissection length, lumen area, total number of dissections) that may affect the efficacy of DCB.
Medulloblastoma is a rare tumor in adults and the use of adjuvant chemotherapy in average risk patients is debated.

Patients included in our study were ⩾16 years of age, had histologically confirmed medulloblastoma, and underwent adjuvant radiotherapy with or without chemotherapy. Average risk was defined according to the Chang classification.

We included 48 average-risk patients. Median follow-up was 151.5 months (95% confidence interval, 124.5-178.5). Both progression-free survival (PFS) and overall survival (OS) were significantly influenced by adjuvant chemotherapy (PFS hazard ratio [HR], 0.334,
= 0.05; OS HR, 0.187,
= 0.017) and by receiving the treatment in a referral center (PFS HR, 0.250,
= 0.008; OS HR, 0.295,
= 0.038).

Treating patients with average-risk medulloblastoma in a referral center improves both PFS and OS, does adding adjuvant chemotherapy.
Treating patients with average-risk medulloblastoma in a referral center improves both PFS and OS, does adding adjuvant chemotherapy.Using a memorable message framework, we explored the content of parental memorable messages about depression and differences in perceptions of parental social support and stigma, relational satisfaction, and depression treatment-seeking among young adults diagnosed with depression (N= 128) based on message type (i.e., content). Casein Kinase chemical Thematic analyses revealed seven prominent categories of parental memorable messages about depression (e.g., We will be there, Depression isn't real). Young adult's perceptions of parental support, stigma, and relational satisfaction differed based on message type, though differences in treatment-seeking based on message type were non-significant. Our findings illuminate the significance of parental communication about depression and how the content of messages about depression are linked to perceptions of parental support, stigma, and relational satisfaction among young adult with depression. Theoretical and practical implications, limitations, and future directions are also discussed.
Survival of peritoneal dialysis (PD) patients in Japan is high, but few reports exist on cause-specific mortality, transfer to haemodialysis (HD) or hybrid dialysis and hospitalisation risks. We aimed to identify reasons for transfer to HD, hybrid dialysis and hospitalisation in the Japan Peritoneal Dialysis and Outcomes Practice Patterns Study.

This observational study included 808 adult PD patients across 31 facilities in Japan in 2014-2017. Information on all-cause and cause-specific mortality and hospitalisation and permanent transfer to HD and PD/HD hybrid therapy were prospectively collected and rates calculated.

Median follow-up time was 1.66 years where 162 patients transferred to HD, 79 transferred to hybrid dialysis and 74 patients died. All-cause and cardiovascular disease (CVD)-related mortality rates were 5.1 and 1.7 deaths/100 patient-years, respectively. Rates of transfer to HD and hybrid therapy were 11.2 and 5.5 transfers/100 patient-years, respectively. Among HD transfers, 40% were duespitalisation rates and how to further reduce hospitalisation rates for Japanese PD patients.Recurrent implantation failure (RIF) is a major limiting factor in the success rates of in-vitro fertilisation despite the remarkable clinical and technological advancement made at improving assisted reproductive technology. The primary purpose of the endometrium is to provide a receptive site for the implantation of the blastocyst and support its growth and subsequent development. Endometrial pathologies such as endometrial polyps, adenomyosis, Asherman's syndrome, chronic endometritis, and congenital Müllerian ducts defect negatively influence the integrity and receptivity of the endometrium, as well as the implantation of the embryo. This review highlights the implications of these endometrial pathologies and their association with RIF.Iran is a semi-arid and arid country which always faces a water shortage crisis. Thus, the water resources in Iran should be studied by accurate methods such as stable isotope techniques. In precipitation sampling stations across Iran, the δ18O (ranges from -16.3 to -0.3 ‰, -4.9 ‰ average), δ2H (-114 to -13 ‰, -24.2 ‰ average) and d-excess (-2.1 to -22.7, 16.5 ‰ average) values are higher compared to δ18O (ranges from -10.9 to -3.1 ‰, -6.7 ‰ average), δ2H (-71 to -6 ‰, -37.4 ‰ average) and d-excess (1.0 to -21.6 ‰, 14.9 ‰ average) values in groundwater stations. Stable isotope distribution maps in precipitation and groundwater were also developed for Iran. The stepwise technique was used to study the role of parameters influencing stable isotopes in Iran precipitation. Results show the dominant role of temperature, elevation and latitude as well as 'cP and MedT' air masses mixture on stable isotope values in precipitation. Furthermore, the contribution percentage of each air mass which influences Iran in groundwater resources recharge was studied using 'Simmr' package in R programming language.
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