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Promotion of Bone fragments Lesions on the skin With the Myeloma Integrin α6-Mediated Osteolytic Signaling.
In the network including these five ROIs, IA also showed increased ROI-to-ROI rsFC. Using a paired t-test in IA subjects before and after 40 days of acupuncture, the increased ROI-to-ROI rsFC was decreased (normalized to HC) with acupuncture, including the rsFC of the right VRP with the left OFC, PMC, and cerebellum, and the rsFC of the left cerebellum with the left OFC, PMC, and right vmPFC. Furthermore, the change in rsFC strength between the right VRP and left cerebellum in IA individuals was found positively correlated with the Internet craving alleviation after acupuncture. Conclusions These findings verified the modulation effect of acupuncture on functional connectivity of reward and habit systems related to the VS in IA individuals, which might partly represent the underlying mechanisms of acupuncture on IA. Copyright © 2020 Yang Wang et al.Purpose Gray matter volume loss, regional cortical thinning, and local gyrification index alteration have been documented in minimal hepatic encephalopathy (MHE). Fractal dimension (FD), another morphological parameter, has been widely used to describe structural complexity alterations in neurological or psychiatric disease. Here, we conducted the first study to investigate FD alterations in MHE. Methods and Materials We performed high-resolution structural magnetic resonance imaging on cirrhotic patients with MHE (n = 20) and healthy controls (n = 21). We evaluated their cognitive performance using the psychometric hepatic encephalopathy score (PHES). The regional FD value was calculated by Computational Anatomy Toolbox (CAT12) and compared between groups. We further estimated the association between patients' cognitive performance and FD values. Results MHE patients presented significantly decreased FD values in the left precuneus, left supramarginal gyrus, right caudal anterior cingulate cortex, right isthmus cingulate cortex, right insula, bilateral pericalcarine cortex, and bilateral paracentral cortex compared to normal controls. In addition, the FD values in the right isthmus cingulate cortex and right insula were shown to be positively correlated with patients' cognitive performance. Conclusion Aberrant cortical complexity is an additional characteristic of MHE, and FD analysis may provide novel insight into the neurobiological basis of cognitive dysfunction in MHE. Copyright © 2020 Qiu-Feng Chen et al.The current research on human-machine interaction interface layout focused on ergonomic analysis, while the research on aesthetics and aesthetic degree calculation of interface layout was insufficient. In order to objectively evaluate the aesthetic degree of interface layout, this paper put forward an aesthetic degree evaluation method of interface design based on Kansei engineering. Firstly, the perceptual image structure of interface aesthetic degree was analyzed from the perspective of aesthetic cognition. Six aesthetic image factors affecting interface aesthetic degree, including proportion, conciseness, order, rhythm, density, and equilibrium, were extracted by factor analysis method, and the variance contribution rate of each factor was taken as the weight. Secondly, according to the six aesthetic degree indexes, the calculation system of interface aesthetic degree was constructed, and the aesthetic degree value of aesthetic image factor was calculated by the corresponding aesthetic degree evaluation mathematical formula. Then, Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) method was used to analyze the order of aesthetic degree superiority of design schemes, and the comprehensive aesthetic degree evaluation was carried out. Finally, the aesthetic degree evaluation of human-machine interaction interface layout of the driller's console of an AC variable frequency drilling rig was taken as an example to verify that this method was helpful for designers to optimize the design scheme. The experimental results showed that the proposed method was feasible and effective compared with the method of paired comparison commonly used in psychophysics. Copyright © 2020 Li Deng and Guohua Wang.Traumatic brain injury (TBI) is one of the injuries that can bring serious consequences if medical attention has been delayed. Commonly, analysis of computed tomography (CT) or magnetic resonance imaging (MRI) is required to determine the severity of a moderate TBI patient. However, due to the rising number of TBI patients these days, employing the CT scan or MRI scan to every potential patient is not only expensive, but also time consuming. Trastuzumab Emtansine in vitro Therefore, in this paper, we investigate the possibility of using electroencephalography (EEG) with computational intelligence as an alternative approach to detect the severity of moderate TBI patients. EEG procedure is much cheaper than CT or MRI. Although EEG does not have high spatial resolutions as compared with CT and MRI, it has high temporal resolutions. The analysis and prediction of moderate TBI from EEG using conventional computational intelligence approaches are tedious as they normally involve complex preprocessing, feature extraction, or feature selection of the signal. Thus, we propose an approach that uses convolutional neural network (CNN) to automatically classify healthy subjects and moderate TBI patients. The input to this computational intelligence system is the resting-state eye-closed EEG, without undergoing preprocessing and feature selection. The EEG dataset used includes 15 healthy volunteers and 15 moderate TBI patients, which is acquired at the Hospital Universiti Sains Malaysia, Kelantan, Malaysia. The performance of the proposed method has been compared with four other existing methods. With the average classification accuracy of 72.46%, the proposed method outperforms the other four methods. This result indicates that the proposed method has the potential to be used as a preliminary screening for moderate TBI, for selection of the patients for further diagnosis and treatment planning. Copyright © 2020 Chi Qin Lai et al.Parameter optimization of a hydrological model is intrinsically a high dimensional, nonlinear, multivariable, combinatorial optimization problem which involves a set of different objectives. Currently, the assessment of optimization results for the hydrological model is usually made through calculations and comparisons of objective function values of simulated and observed variables. Thus, the proper selection of objective functions' combination for model parameter optimization has an important impact on the hydrological forecasting. There exist various objective functions, and how to analyze and evaluate the objective function combinations for selecting the optimal parameters has not been studied in depth. Therefore, to select the proper objective function combination which can balance the trade-off among various design objectives and achieve the overall best benefit, a simple and convenient framework for the comparison of the influence of different objective function combinations on the optimization results is urgently needed.
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