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An organized review and also meta-analysis of anticoagulation treatments for portal vein thrombosis in individuals with cirrhosis: to deal with or otherwise to take care of?
Nuclear medicine is a medical specialty that uses unsealed radioactive sources involving several handling procedures with some critical points before, during, and after the examination and therapies performed, requiring special attention to the occurrence of a possible accident or incident over clinical routine. The accidents and incidents in nuclear medicine can involve agents such as workers, patients, public or caregivers, and even the environment. Although expected, the number of occurrences and their nature are not well understood due to the absence of a Brazilian reporting tool for incidents or accidents. This paper aims to develop a web-based nuclear medicine incident and accident notification system named SINMED (Nuclear Medicine Notification System). Specific forms were developed in an offline system in html5 language with an online system interface according to google forms platform. The developed forms were based on existing international notification templates with the perspective of nuclear medicine services in operation applying Brazilien regulations.Focused electron beam induced deposition of pure materials from aqueous solutions has been of interest in recent years. However, controlling the liquid film in partial vacuum is challenging. Here we modify the substrate to increase control over the liquid layer in order to conduct a parametric study of copper deposition in an environmental scanning electron microscope. We identified the transition from electron to mass-transport limited deposition as well as two additional regimes characterized by aggregated and high-aspect ratio deposits. We observe a high deposition efficiency of 1-10 copper atoms per primary electron that is consistent with a radiation chemical model of the deposition process.Working Group (WG) 6 "Computational Dosimetry" of the European Radiation Dosimetry Group (EURADOS) promotes good practice in the application of computational methods for radiation dosimetry in radiation protection and the medical use of ionizing radiation. Its cross-sectional activities within the association cover a large range of current topics in radiation dosimetry, including more fundamental studies of radiation effects in complex systems. In addition, WG 6 also performs scientific research and development as well as knowledge transfer activities, such as training courses. Monte Carlo techniques, including the use of anthropomorphic and other numerical phantoms based on voxelized geometrical models, have a strong part in the activities pursued in WG 6. However, other aspects and techniques, such as neutron spectra unfolding, play an important role as well. A number of intercomparison exercises have been carried out in the past to provide information on the accuracy with which computational methods are applied and whether best practice is being followed. Within the exercises that are still ongoing, the focus has changed towards assessing the uncertainty that can be achieved with these computational methods. Furthermore, the future strategy of WG 6 also includes an extension of the scope toward experimental benchmark activities and evaluation of cross-sections and algorithms, with the vision of establishing a gold standard for Monte Carlo methods used in medical and radiobiological applications.Recently topological semimetals emerge as a new platform to realise topological superconductivity. Here we report the emergent superconductivity in single-crystals of Re doped type-IIWeyl semimetal NiTe2. The magnetic and transport measurements highlight that Re substitution in Ni-site induces superconductivity at a maximum temperature of 2.36 K. Hall effect and specific heat measurements indicate that Re substitution is doping hole and facilitates the emergence of superconductivity by phonon softening and enhancing the electron-phonon coupling.Facile synthesis of flexible electrodes with high reversible capacity plays a key role in meeting the ever-increasing demand for flexible batteries. Herein, we incorporated Sn-based metal-organic framework (Sn-MOF) templates into crosslinked one-dimensional carbon nanofibers (CNFs) using an electrospinning strategy and obtained a hierarchical porous film (Sn@C@CNF) after a carbothermal reduction reaction. Merits of this modification strategy and its mechanism in improving the electrochemical performance of Sn nanoparticles (NPs) were revealed. Electrospun CNFs substrate ensured a highly conductive skeleton and excellent mechanical toughness, making Sn@C@CNF a self-supported binder-free electrode. Serving as a self-sacrificing template, Sn-MOF provided Sn NPs and derived into porous structures on CNFs after pyrolysis. The hierarchical porous structure of the carbon substrate was beneficial to enhancing the Li+/Na+ storage of the active materials, and the carbon wrappings derived from polyacrylonitrile (PAN) nanofibers and the MOF skeleton could jointly accommodate the violent volume variation during cycling, enabling Sn@C@CNF to have excellent cycle stability. The Sn@C@CNF anode exhibited a stable discharge specific capacity of 610.8 mAh g-1 under 200 mA g-1 for 180 cycles in lithium ion batteries (LIBs) and 360.5 mAh g-1 under 100 mA g-1 after 100 cycles in sodium ion batteries (SIBs). As a flexible electrode, Sn@C@CNF demonstrated a stable electromechanical response to repeated 'bending-releasing' cycles and excellent electrochemical performance when assembled in a soft-pack half-LIB. This strategy provided promising candidates of active materials and fabrication methods for advanced flexible batteries.The nanoflakes of SnS2/SnO2heterostructure and SnS2were synthesized by a one-step SnO2-templated chemical vapor deposition method. The metal oxide-assisted growth mechanism of SnS2/SnO2heterostructure and SnS2nanoflakes were realized through investigating serial microstructures of products with varied growth time. Furthermore, the photocatalytic activity for MB dyes degradation of varied growth time products was used to explore the effect of product microstructure under the visible light irradiation. The SnO2/SnS2heterostructure and the oxide vacancies of nanoflakes demonstrated an improved visible light photocatalytic performance for MB degradation, which was around twice of the pure SnS2nanoflakes and better than P25. The results of different scavengers on the degradation efficiency for MB indicate the·O2-, and ·OH are the main active species in the photodegradation reaction. The one-step growth mechanism of SnS2/SnO2could prove a facile process to grow metal oxide-metal sulfide heterostructure.We fabricate nanolayer alumina capacitor and apply high electric fields, close to 1 GV m-1, to inject charges in the dielectric. Asymmetric charge distributions have been achieved due to the selectivity of the quantum tunneling process. Namely, the electrons near the Fermi level cannot tunnel intoregions near the cathode, where the total energy would be less than the potential energy. This mechanism exhibits a strong tendency to populate charge traps located near the anode, i.e. the regions where their potential energy is the lowest. click here Such spatially selective charging of the dielectric allows a permanent bulk charge storage in the dielectric layer, even if the capacitor plates are short-circuited, provided that the temperature is sufficiently low so that the conductivity of the dielectric is negligible. The stored charge can be recovered if the temperature is increased above ~250 K for the dielectric tested, i.e. Al2O3. In our experiments, the total charge stored in the dielectric was up to seven and a half times higher than the charge stored on the capacitor plates. Also, measurements of the breakdown voltage show that the breakdown electric field, i.e. the dielectric strength, is independent of the thickness of the dielectric.Oxidative stress induces damages of various cell types or tissues through a repetitive imbalance between the systemic manifestation of reactive oxygen species (ROS) and detoxification of the reactive intermediates. Thioacetamide (TAA) is well known for causing several degenerative diseases by oxidative stress. However, study of the antioxidant mechanisms of stem cells in TAA-injured rat model is insufficient. Therefore, we investigated the effect of placenta-derived mesenchymal stem cells (PD-MSCs) transplantation on liver and ovary of TAA-injured rat models to study the antioxidant effect in degenerative diseases. In TAA-injured rat model, PD-MSCs engrafted into damaged organ including liver and ovary in PD-MSCs transplanted groups (Tx) compared with non-transplanted groups (NTx) (*p less then 0.05). Transplanted PD-MSCs reduced inflammatory factors and upregulated oxidative stress factors in Tx compared with NTx (*p less then 0.05). Also, transplanted PD-MSCs enhanced antioxidants factors and organ functional restoration factors in Tx compared with NTx. These data show that PD-MSC transplantation triggers the regeneration of organ (e.g., liver and ovary) damaged by oxidative stress from TAA treatment via activating antioxidant factors. Therefore, these data suggest the therapeutic potential via antioxidant effect and help understand the therapeutic mechanism of PD-MSCs in damaged tissues such as in liver and reproductive system.Diabetic encephalopathy (DE) is a global concern and Gordian knot worldwide. miRNA-132 (miR-132) is a class of negative gene regulators that promote diabetic pathologic mechanisms and its complications. However, the molecular mechanisms of miR-132 in DE are elusive, thus an alternative therapeutic strategy is urgently in demand. The present study explored the protective effect and the underlying mechanism of miR-132 on DE via the GSK-β/Tau signaling pathway. Experimentally, a type 2 DM rat model was developed by incorporating a high-fat diet and streptozotocin injection. Further, the DE model was screened via the Morris Water Maze test. Primary hippocampal neurons and HT-22 cells were used for in vitro analysis. We found that hyperglycemia exacerbates cognitive impairment in T2DM rats. When we isolated the primary hippocampus neurons, the expression of miR-132 RNA was low in both the DE hippocampus and primary neurons. GSK-3β and Tau 404 were highly expressed in injured HT-22 cells and diabetic hippocampal tissues. miR-132 downregulated the expression of GSK-3β. Besides, a binding and colocalized relationship between GSK3β and Tau was also reported. These findings suggest that miR-132 exerts protective effects from DE injury by repressing GSK-3β expression and alleviating Tau hyperphosphorylation in HT-22 cells and hippocampus tissues.Septic shock is one of the most significant health concerns across the world, involving hypo-perfusion and defects in tissue energy. The current study investigates the role of NLR family CARD domain containing protein 4 (NLRC4) in septic shock-induced inflammatory reactions, lung tissue injuries, and dendritic cell (DC) apoptosis. Septic shock mice models were established by modified cecal ligation and puncture and injected with retroviral vector expressing siRNA-NLRC4. DCs were then isolated and transfected with siRNA-NLRC4. The degree of lung tissue injury, cell cycle distribution, cell apoptosis and cell viability of DCs were assessed. NLRC4 was found to be expressed at high levels in mice with septic shock. NLRC4 silencing inhibited the activation of the NOD-like receptor (NLR) pathway as evidenced by the decreased levels of NOD1, NOD2, RIP2, and NF-κB. In addition, NLRC4 silencing reduced the inflammatory reaction as attributed by reduced levels of IL-1β, TNF-α and IL-6. Suppressed NLRC4 levels inhibited cell viability and promoted cell apoptosis evidenced by inhibited induction of DC surface markers (CD80, CD86, and MHC II), along with alleviated lung tissue injury.
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