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Moreover, NE and smoking or inactive physical activity exhibited an excess risk of high C-Ca (RERI 0.47, 95% CI 0.09-0.85 for smoking or RERI 0.46, 95% CI 0.01-0.90 and AP 0.51, 95% CI 0.03-0.99 for physical activity). Our study suggests that CKD patients who were enrolled in the NE program had better kidney function. Thus, NE could be associated with slowing kidney function decline and improving cardiovascular risk factors.Stochastic resonance (SR), a typical randomness-assisted signal processing method, has been extensively studied in bearing fault diagnosis to enhance the feature of periodic signal. In this study, we cast off the basic constraint of nonlinearity, extend it to a new type of generalized SR (GSR) in linear Langevin system, and propose the fluctuating-mass induced linear oscillator (FMLO). Then, by generalized scale transformation (GST), it is improved to be more suitable for exacting high-frequency fault features. Moreover, by analyzing the system stationary response, we find that the synergy of the linear system, internal random regulation and external excitement can conduct a rich variety of non-monotonic behaviors, such as bona-fide SR, conventional SR, GSR, and stochastic inhibition (SI). Based on the numerical implementation, it is found that these behaviors play an important role in adaptively optimizing system parameters to maximally improve the performance and identification ability of weak high-frequency signal in strong background noise. N-Acetyl-DL-methionine cell line Finally, the experimental data are further performed to verify the effectiveness and superiority in comparison with traditional dynamical methods. The results show that the proposed GST-FMLO system performs the best in the bearing fault diagnoses of inner race, outer race and rolling element. Particularly, by amplifying the characteristic harmonics, the low harmonics become extremely weak compared to the characteristic. Additionally, the efficiency is increased by more than 5 times, which is significantly better than the nonlinear dynamical methods, and has the great potential for online fault diagnosis.The stability of steel-slag road materials remains a critical issue in their utilization as an aggregate base course. In this pursuit, the present study was envisaged to investigate the effects of fly ash on the mechanical properties and expansion behavior of cement-fly-ash-stabilized steel slag. Strength tests and expansion tests of the cement-fly-ash-stabilized steel slag with varying additions of fly ash were carried out. The results indicate that the cement-fly-ash-stabilized steel slag exhibited good mechanical properties. The expansion rate and the number of bulges of the stabilized material reduced with an increase in the addition. When the addition of fly ash was 30-60%, the stabilized material was not damaged due to expansion. Furthermore, the results of X-CT, XRD and SEM-EDS show that fly ash reacted with the expansive component of the steel slag. In addition, the macro structure of the stabilized material was found to be changed by an increase in the concentration of the fly ash, in order to improve the volumetric stability. Our study shows that the cement-fly-ash-stabilized steel slag exhibits good mechanical properties and volumetric stability with reasonable additions of fly ash.The enhancement of both thermal and mechanical properties of epoxy materials using nanomaterials becomes a target in coating of the steel to protect it from aggressive environmental conditions for a long time, with reducing the cost. In this respect, the adhesion properties of the epoxy with the steel surfaces, and its proper superhyrophobicity to repel the seawater humidity, can be optimized via addition of green nanoparticles (NPs). In-situ modification of silver (Ag) and calcium carbonate (CaCO3) NPs with oleic acid (OA) was carried out during the formation of Ag-OA and CaCO3-OA, respectively. The epoxide oleic acid (EOA) was also used as capping for Ca-O3 NPs by in-situ method and epoxidation of Ag-OA NPs, too. The morphology, thermal stability, and the diameters of NPs, as well as their dispersion in organic solvent, were investigated. The effects of the prepared NPs on the exothermic curing of the epoxy resins in the presence of polyamines, flexibility or rigidity of epoxy coatings, wettability, and coatings durability in aggressive seawater environment were studied. The obtained results confirmed that the proper superhyrophobicity, coating adhesion, and thermal stability of the epoxy were improved after exposure to salt spray fog for 2000 h at 36 °C.Somatostatin-secreting δ-cells have aroused great attention due to their powerful roles in coordination of islet insulin and glucagon secretion and maintenance of glucose homeostasis. δ-cells exhibit neuron-like morphology with projections which enable pan-islet somatostatin paracrine regulation despite their scarcity in the islets. The expression of a range of hormone and neurotransmitter receptors allows δ-cells to integrate paracrine, endocrine, neural and nutritional inputs, and provide rapid and precise feedback modulations on glucagon and insulin secretion from α- and β-cells, respectively. Interestingly, the paracrine tone of δ-cells can be effectively modified in response to factors released by neighboring cells in this interactive communication, such as insulin, urocortin 3 and γ-aminobutyric acid from β-cells, glucagon, glutamate and glucagon-like peptide-1 from α-cells. In the setting of diabetes, defects in δ-cell function lead to suboptimal insulin and glucagon outputs and lift the glycemic set-point. The interaction of δ-cells and non-δ-cells also becomes defective in diabetes, with reduces paracrine feedback to β-cells to exacerbate hyperglycemia or enhanced inhibition of α-cells, disabling counter-regulation, to cause hypoglycemia. Thus, it is possible to restore/optimize islet function in diabetes targeting somatostatin signaling, which could open novel avenues for the development of effective diabetic treatments.Congenital eye defects represent a large class of disorders affecting roughly 21 million children worldwide. Microphthalmia and anophthalmia are relatively common congenital defects, with approximately 20% of human cases caused by mutations in SOX2. Recently, we identified the RNA-binding motif protein 24a (Rbm24a) which binds to and regulates sox2 in zebrafish and mice. Here we show that morpholino knockdown of rbm24a leads to microphthalmia and visual impairment. By utilizing sequential injections, we demonstrate that addition of exogenous sox2 RNA to rbm24a-deplete embryos is sufficient to suppress morphological and visual defects. This research demonstrates a critical role for understanding the post-transcriptional regulation of genes needed for development.
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