Notes

Affect regarding Doping a Phytosteryl Sulfate around the Properties associated with Liposomes Made of Over loaded and Unsaturated Phosphatidylcholines.
An ultrafast fiber chirped-pulse amplification laser system based on a coherent combination of 16 ytterbium-doped rod-type amplifiers is presented. It generates 10 mJ pulse energy at 1 kW average power and 120 fs pulse duration. A partially helium-protected, two-staged chirped-pulse amplification grating compressor is implemented to maintain the close to diffraction-limited beam quality by avoiding nonlinear absorption in air.We report on a thin-disk laser system with more than 10 kW of output power and a beam quality of M2=1.76 at an overall optical-to-optical efficiency of 51%. The system consists of two thin-disk laser oscillators and a thin-disk multi-pass amplifier system. To reach high output powers while maintaining good beam quality, the output beams of two identical laser oscillators are polarization-combined. Subsequently, the beam is amplified in a multi-pass system. To the best of our knowledge, this is the highest output power achieved for a thin-disk laser system with a beam quality close to fundamental mode.Modern image detectors with exceptionally low readout noise of about one electron (e-) per pixel allow for applications with ultra-low levels of light intensity. In this Letter, we report a property of scientific CMOS detectors that makes accurate spectroscopy at ultra-low levels of illumination depending on a thorough calibration procedure. Our results reveal that pixel sensitivity to light may have significant nonlinearity at accumulation levels smaller than 50e- per pixel. The sensitivity decreases by a factor of ∼0.7 at an accumulation level of ∼1e- per pixel and photon detection rate of about 170 Hz. We demonstrate that the nature of this nonlinearity might be quite complicated the photoelectric response of a pixel depends on both the number of accumulated electrons and the detection count rate (at rates larger than 250 Hz).A stable single wavelength random fiber laser (RFL) with a partial-reflection random fiber grating (PR-RFG) for high temperature sensing is proposed and demonstrated for the first time, to the best of our knowledge. The PR-RFG is fabricated with the help of a femtosecond laser, with its highest reflection peak significantly higher than all other reflection peaks, which can ensure the stability of this filter-free RFL. Theoretical calculations also show that such a PR-RFG should be designed with reflectivity in the range of ∼30%-90% to obtain one reflection peak significantly higher than other peaks. Tiplaxtinin clinical trial The threshold of this laser is only 6.4 mW. In addition, the RFL realizes temperature sensing in the range from 25°C to 500°C and has an optical signal-to-noise ratio of up to 70 dB.Surface enhanced Raman spectroscopy (SERS) and stimulated Raman spectroscopy (SRS) are well established techniques capable of boosting the strength of Raman scattering. The combination of both techniques (surface enhanced stimulated Raman spectroscopy, or SE-SRS) has been reported using plasmonic nanoparticles. In parallel, waveguide enhanced Raman spectroscopy has been developed using nanophotonic and nanoplasmonic waveguides. Here, we explore SE-SRS in nanoplasmonic waveguides. We demonstrate that a combined photothermal and thermo-optic effect in the gold material induces a strong background signal that limits the detection limit for the analyte. The experimental results are in line with theoretical estimates. We propose several methods to reduce or counteract this background.An all-fiber orbital angular momentum (OAM) mode generator enabling simultaneous generation of the second- and the third-order OAM modes with conversion efficiencies larger than 95% has been proposed and experimentally demonstrated, which is realized by using a high-order helical long-period fiber grating (HLPG) written in a thinned four-mode fiber. This is the first time, to the best of our knowledge, that two such OAM modes have been simultaneously obtained at wavelengths ranging from 1450 to 1620 nm by using only one fiber component, i.e., the HLPG. The proposed method provides a new way to simultaneously generate different orders of the OAM modes, which would further expand the OAM's applications to the fields of the optical tweezers, microscopy, and fiber communication, etc.In this Letter, we design and fabricate elliptical-core (ECORE) chalcogenide-polymethyl methacrylate (As2Se3-PMMA) microfibers to explore the birefringence impact on stimulated Brillouin scattering. Numerical simulations based on the finite-element method and elastodynamic equation are utilized to calculate the phase and group birefringence and Brillouin gain spectra of the fundamental mode in three ECORE As2Se3-PMMA microfibers at different core diameters. Experimentally measured and numerically calculated results show that as the core diameter of the minor axis of an ECORE microfiber with a ratio of 1.108 is reduced from 1.50 µm to 0.87 µm, a high group birefringence of ∼10-3 to ∼10-2 and a large Brillouin frequency shift difference of ∼6MHz to ∼30MHz are achieved, while the Brillouin gain spectra are broadened significantly from ∼70MHz to ∼140MHz. The high-birefringence ECORE As2Se3-PMMA microfiber is important for Brillouin sensing due to the tailorable high birefringence and ultrahigh nonlinearity.We propose a scheme for imaging mid-infrared (MIR) wavelengths via pre-excitation-assisted up-conversion luminescence in lanthanide ion (Ln3+)-doped Self-organizing Optical FIber Array (SOFIA) crystal. First, near-infrared pre-excitation wavelength excites an electron from the ground state to an excited state of Ln3+. Next, the MIR wavelength to be imaged promotes this excited electron to a higher-lying energy state. Finally, relaxation of the electron from the higher-lying energy state to the ground state emits the up-conversion luminescence in the visible region, completing the MIR-to-visible wavelength conversion. An analysis of the 4f to 4f intra-configurational energy level transitions in Ln3+, together with an appropriate selection of the pre-excitation wavelength and the visible luminescence constrained within the 500-700 nm wavelength range, reveals that trivalent erbium (Er3+), thulium (Tm3+), holmium (Ho3+), and neodymium (Nd3+) can be used to image MIR wavelengths. Our proposed scheme, called MIR imAging through up-Conversion LuminEscence in a SOFIA crystal, will enable the imaging of MIR wavelengths using low-cost optics and readily available silicon-based detectors in the visible spectral region and will open up new possibilities for MIR wavelength detection and imaging.Using ultra-high repetition rate lasers (≥100kHz) is one of the most promising strategies for the next generation of satellite laser ranging (SLR) systems. We present successful 1 MHz repetition rate SLR to targets up to inclined geosynchronous orbits at nighttime. Among those, a maximum return rate of up to 53% was achieved, equivalent to 265 k returns per second for the satellite Swarm-B. In addition, daytime megahertz (MHz) SLR was realized by utilizing a propagated MHz range gate to reduce the massive background noise. In the future, MHz SLR will greatly improve current technology with respect to data amount and data precision, shorter acquisition time, target signature detection, and attitude determination.The first-order helical Laguerre-Gaussian mode (also called donut mode) is used to improve the energy throughput of nonlinear spectral broadening in gas-filled multipass cells. The method proposed in this Letter enables, for the first time to the best of our knowledge, the nonlinear spectral broadening of pulses with energies beyond 100 mJ and is suitable for an average power of more than 500 W while conserving an excellent spatio-spectral homogeneity of ∼98% and a Gaussian-like focus profile. Additionally compressibility from 1.3 ps to 37 fs is demonstrated.This publisher's note contains corrections to Opt. Lett.46, 685 (2021)OPLEDP0146-959210.1364/OL.415087.The optimal timing of antiretroviral therapy (ART) initiation in human immunodeficiency virus (HIV)-infected patients with cryptococcal meningitis (HIV/CM) is controversial. We designed a clinical trial to inves-tigate the optimal timing for ART initiation in HIV/CM patients. This will be a multicenter, prospective, and randomized clinical trial. Each enrolled patient will be randomized into either the early ART arm or the deferred ART arm. We will compare the mortality and incident rates of immune reconstitution inflammatory syndrome between the two arms. We hope to elucidate the optimal timing for ART initiation in HIV/CM patients.A 43-year-old male with type 2 diabetes, under treatment with 5 mg/day of dapagliflozin, was referred to our hospital with upper left abdominal pain and marked hypertriglyceridemia (triglycerides [TGs], 5,960 mg/dl). He was also on a low-carbohydrate diet that promoted ketosis under sodium glucose cotransporter 2 (SGLT2) inhibitor administration. Polyacrylamide gel electrophoresis revealed a remarkable increase in very-low-den-sity lipoprotein, a TG-rich lipoprotein particle synthesized in the liver using free fatty acids derived from adi-pose tissue. Although SGLT2 inhibitors generally improve the lipid profile, under certain conditions such as a low-carbohydrate diet, they may adversely exacerbate the lipid profile via ketosis.A 21-year-old man consulted our hospital for treatment of a spinal giant cell tumor (GCT) of Enneking stage III. Lower lumbar-spine tumors and severe spinal canal stenosis are associated with high risk for surgical mor-bidity. Stability was temporarily secured with a percutaneous pedicle screw fixation in combination with deno-sumab, which shrank the tumor. Total en bloc spondylectomy was then performed 6 months after initiation of denosumab, and the patient was followed for 3 years. There was no local recurrence, and bony fusion was obtained. Minimally invasive surgery and denosumab allowed safer and easier treatment of a collapsing lower lumbar extra-compartmental GCT.Bronchopleural fistula (BPF) is a severe complication following lung resection. We present the case of a patient with a history of advanced lung cancer, who had undergone induction chemoradiotherapy followed by right middle and lower lobectomy, and who developed BPF after completion right pneumonectomy. Although we had covered the bronchial stump with an omental pedicled flap, BPF was found on postoperative day 19. We covered the fistula with n-butyl-2-cyanoacrylate (NBCA) using bronchoscopy. Although we had to repeat the NBCA treatment, we ultimately cured the patient's BPF and no recurrence was observed up to 15.2 months after surgery.Although chronic kidney disease (CKD) commonly develops after lung transplantation (LT), living-donor kid-ney transplantation (LDKT) for CKD after LT is known to provide favorable outcomes. We describe the long-term follow-up findings of a patient who underwent LDKT after bilateral cadaveric LT. A 37-year-old male underwent LDKT for CKD 18 years after receiving bilateral cadaveric LT. He developed chronic lung allograft dysfunction (CLAD) 20 years after the LT; however, at 26 years after the initial LT, he is still alive with no pro-gression of CLAD or CKD. KT could be a viable option for CKD even after LT in Japan.
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