Notes

Bacteriuria opposition styles along with the suitability regarding urinalysis being an original analysis application in a post-antibiotic age.
033). Three oncogenic pathways (p53, cell cycle, PI3K) were altered with statistical significance in SNs, while only RNA splicing/processing pathway was significantly altered in SSNs (FDR q<0.1). Also, SSNs had significantly lower number of pathway alterations (P<0.001). Finally, SSNs and SNs showed distinct evolutionary trajectories regarding somatic mutations during early-stage LUAD progression.

This study performed the first direct comparative genomic profiling in pathologic stage I invasive LUAD by radiological subtype, highlighting a less complex genomic architecture of SSNs, which might be the molecular interpretation of their indolent tumor behavior.
This study performed the first direct comparative genomic profiling in pathologic stage I invasive LUAD by radiological subtype, highlighting a less complex genomic architecture of SSNs, which might be the molecular interpretation of their indolent tumor behavior.Metal contamination in estuary was monitored globally using shellfish while estuarine metal loadings were influenced by socioeconomic development in watershed, i.e., a watershed-estuary chain effect. Socioeconomic pattern of metal loadings in estuarine shellfish has scarcely been studied. Eight metals and metalloids (As, Cd, Cr, Cu, Hg, Ni, Pb, and Zn) highly associated with anthropogenic activities were quantified in tissue and shell of bivalves and gastropods (two feeding-habits) among 7 estuaries along the Southeastern China coast in the period 2016-2019. Results indicated that Cu and Zn in shellfish had the greatest loadings at 1,663 and 6,828 mg kg-1 dry mass in tissue and 387 and 151 mg kg-1 dry mass in shell, respectively, in the most developed Estuary Yong. Metal loadings in tissue and shell of bivalves (6 common species) and gastropods (3 common species) in the estuaries were highly associated with urbanization and socioeconomic indicators in their watersheds. The socioeconomic patterns had evident shellfish class-specification and metal-dependency due to the feeding-habit. The class-specification was confirmed by the fractionation of stable isotope compositions for the socioeconomic pattern of Pb loadings in both tissue and shell. In short, both shellfish class-specification and metal-dependency hinted that multi-bioindicators might be required for a comprehensive understanding of the estuarine environment quality, in particular at two dimensions of water and sediment.The development of efficient catalysts for hydrogen evolution reaction (HER) from water splitting is one of the most promising strategies to achieve the goal of peak carbon dioxide emissions and carbon neutrality. Herein, Ru nanoclusters decorated MoSe2 nanosheets supported on a Crepis tectorum fluff biomass-derived hollow carbon tube (Ru-MoSe2/CMT) are prepared as the HER catalysts in both alkaline and acidic conditions. The Ru modification induces the transformation of MoSe2 from 2H phase to 1T phase. Benefiting from the strong water dissociation ability of Ru, Ru-MoSe2/CMT exhibits a low overpotential of 70 mV with a Tafel slope of 39 mV dec-1 in 1 M KOH. Furthermore, the assembled Ru-MoSe2/CMT || RuO2 system with a low cell voltage of 1.54 V at 10 mA cm-2 exhibits outstanding overall water splitting performance superior to Pt/C || RuO2 system. The Ru-MoSe2/CMT || RuO2 system also achieves the excellent stability of up to 30 h in 1 M KOH. The synergy effect between Ru and MoSe2, as well as the improved electron transfer kinetics provided by the biomass-derived carbon substrate together contribute to the excellent HER activity of Ru-MoSe2/CMT.As an efficient non-precious metal catalyst for the oxygen evolution reaction (OER), phosphides suffer from poor electrical conductivity, so it is still a challenge to reasonably design their structures to further improve their conductivity and OER performances. Here, we present a novel Ni5P4/N-doped carbon@CoFeP/N-doped carbon composite (Ni5P4/NC@CoFeP/NC) as electrocatalysts for OER. This elaborate structure consists of Ni5P4/NC derived from Ni-MOF and CoFeP/NC derived from CoFe-Prussian blue analog MOF (Co-Fe PBA). The cube-like CoFeP/NC are scattered and uniformly coated on the sheet of Ni5P4/NC flowers. Among them, NC can enhance the conductivity of phosphides, while CoFeP/NC can increase the electrochemical active area, which benefit the properties of Ni5P4/NC@CoFeP/NC. Notably, the Ni5P4/NC@CoFeP/NC catalyst possesses outstanding OER performances with a low overpotential of 260 and 303 mV at a current density of 10 and 100 mA·cm-2, an ultra-low Tafel slope of 31.1 mV·dec-1 and excellent stability in 1 M KOH. XPS analysis shows that proper chemical composition promotes the oxidation of transition metal species and the chemisorption of OH-, thus accelerating the OER kinetics. Therefore, this work provides a hopeful method for designing and preparing transition metal phosphide/carbon composite as OER electrocatalysts.The low toxicity and good photo active property endow bismuth based metal-organic frameworks (MOFs) potential candidates for efficient light-sensitive drug carrier. In this work, SU-101, composed of Bi and ellagic acid (EA), is found to display high ciprofloxacin (CIP) loading ratio (85.8%) and controlled CIP release under light illumination (the maximum CIP release ratio is 95.56%). Further investigations suggest that hydrogen bond between the CO group in EA and the -OH group in CIP is responsible for above behavior. Light irradiation decreases the electron density around the CO group in EA, which consequently leads to the broken of the hydrogen bond and therefore the release of CIP. Further investigations suggest that SU-101 is universal for other drugs, such as norfloxacin (NOR), amoxicillin (AMO), tetracycline (TET) and doxorubicinhydrochloride (DOX), since all of them can form hydrogen bond with SU-101. This work suggests that SU-101 holds great potential as efficient light-sensitive drug carrier, and the investigation of other Bi based MOFs as drug carrier is under investigation.The capacity attenuation of transition metal oxides (TMOs) and metal-organic frameworks (MOFs) is the obstacle for practical application in lithium ion batteries, due to the extensive volume variation upon charge/discharge cycles. Herein, a hierarchical composite material with copper oxide (CuO) multi-yolks and copper-1, 3, 5-benzenetricarboxylate (Cu-BTC) shell is synthesized by a facile method to study the effect of the hierarchical structure on the electrochemical performance. The porosity and pore volume of CuO@Cu-BTC composites are optimized to buffer the volume change and facilitate the infiltration of electrolytes by altering reaction conditions. The CuO@Cu-BTC (20 h) with the largest surface area and pore volume delivers an excellent reversible capacity of 780.7 mAh g-1 at 200 mA g-1 after 100 cycles, and ultrastable long-term performance with a specific capacity of 569 mAh g-1 at a current density of 1000 mA g-1 after 900 cycles. The corresponding full battery shows moderate capacity retention from 149.4 to 125.8 mAh g-1 after 70 cycles, with a specific capacity retention of 84.2%, based on the mass of lithium iron phosphate (LiFePO4) at 0.2 C (1 C = 170 mA g-1). This strategy applies copper oxide as the metal source of the coordination compound, as well as the internal yolks, which can be extended to the in-situ construction of other hierarchical composites, providing a new avenue for practical application of TMOs and MOFs as anode materials.Considering that hexavalent chromium ions (Cr6+) with high toxicity poses a huge threat to human health and the ecological environment, constructing a rapid and accurate sensing platform is of great significance in detecting the toxic substance. The novel nitrogen and boron co-doped carbon quantum dots (N, B-CQDs) from lignin are synthesized as fluorescent sensors for the detection of Cr6+. The synthetic processes involve the acid hydrolysis step followed by the hydrothermal treatment step. Lignin is firstly depolymerized by cleaving ether bonds in the acidolysis, and N, B-CQDs are consequently formed by the aromatic re-fusion of lignin nanoparticles in the hydrothermal process. The lignin-derived N, B-CQDs show triple emission of purple, blue and green fluorescence under the excitation of 300, 330, and 490 nm, respectively. The triple-emission N, B-CQDs are applied for the triple-channel detection of Cr6+, which exhibit highly sensitive and selective fluorescence quenching for Cr6+ with good linearity (R2 ≤ 0.996) and very low limit of detection as 0.054, 0.049, and 0.077 μM under the excitation of 300, 330 and 490 nm, respectively. The utilization of renewable lignin as CQDs-based fluorescent sensors opens a new avenue for the rapid and accurate detection of Cr6+ through a multichannel sensing platform.Diabetic wound treatment remains a major challenge due to the difficulties of eliminating bacterial biofilm and relieving wound hypoxia. Kinase Inhibitor Library cell assay To address these issues simultaneously, a multifunctional Dex-SA-AEMA/MnO2/PDA (DSAMP) hydrogel platform was developed with excellent biocompatibility and porous structure. The hydrogel could absorb the exudate, maintain humidity and permeate oxygen, which was prepared by encapsulating polydopamine (PDA) and manganese dioxide (MnO2) into Dex-SA-AEMA (DSA) hydrogel by UV irradiation. With the addition of PDA, the DSAMP hydrogel was proved to eliminate the biofilm after NIR photodynamic therapy (PTT, 808 nm) irradiation at 54 °C. Furthermore, in order to mitigate hypoxia wound microenvironment, MnO2 nanoparticles were added to convert the endogenous hydrogen peroxide (H2O2) into oxygen (O2, 16 mg L-1). The diabetic wound in vivo treated by DSAMP hydrogel was completely healed on 14 days. It was revealed that the DSAMP hydrogel possessed a great potential as dressing for diabetic chronic wound healing.Microplastic pollution is widely studied; however, research into the effects of large-scale firework displays and the impact on surrounding waterways appears to be lacking. This study is potentially the first to look at microplastic abundance in rivers after a major firework event. To assess the impact of the 2020 New Year's firework display in London, a 3 litre water sample was collected over nine consecutive days at Westminster on the River Thames. A total of 2760 pieces of microplastics (99% fibres) were counted using light microscopy, and further analysis was performed on representative plastic samples (354) using Fourier Transform Infrared Spectroscopy (FTIR). Whilst anthropogenic microfibres made up 11%, most microplastic identified (13.3%) were polychloroprene. This study demonstrates the occurrence of a short-term influx of microplastics in the River Thames following the New Year fireworks, which will have an additional detrimental impact on the ecology and aquaculture of the river and neighbouring waterways.This study aims to evaluate the seasonal and spatial characteristics of hydrochemistry and DO isotopes and identify the eco-environmental threats under the background of saline intrusion and human activities in Yellow River Delta (YRD). Analyses for major ions (i.e., K+, Na+, Ca2+, Mg2+, SO42-, HCO3- and Cl-), nitrate ion (NO3-) and isotopic composition are performed for precipitation, river water, wetland water and sea water. Based on the range of δ2H and δ18O as well as their relations, the mixing between multiple sources and evaporation are confirmed. Electrical conductivity (EC), concentration of NO3-, soluble sodium percentage (SSP) and magnesium hazard (MH) are employed as indicators to reflect the ecological risks from salinity, agricultural pollutants, sodium and magnesium. By hierarchical cluster analysis (HCA), the samples of wetland water are grouped associated with those of river water. The characteristic reflects 3 patterns of risks in wetlands, including saline intrusion, human activities and their mixed influence.
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