Notes

Cybersecurity involving Aerobic Implantable Electronic Devices and also Rural Programming.
Plasma-derived von Willebrand factor/factor VIII (pdVWF/FVIII; VONCENTO
, CSL Behring) is a high-concentration, low-volume, high-purity concentrate, which contains a high level of high-molecular-weight multimers and a VWF/FVIII ratio of ~2.41. The SWIFT ("Studies with von Willebrand factor/Factor VIII") program is evaluating pdVWF/FVIII in patients with von Willebrand disease (VWD). The long-term efficacy and safety profile of pdVWF/FVIII was investigated in this multicenter, open-label, extension study.

Pediatric, adolescent, and adult patients with VWD who required treatment of non-surgical bleeds (NSBs), treatment during surgical events or who were receiving prophylaxis and who had completed one of two previous clinical trials of pdVWF/FVIII were included. Efficacy and safety analyses were performed for on-demand (n=10), prophylaxis (n=8), or on-demand and prophylaxis (n=2) treatment in patients pre-treated with pdVWF/FVIII for ≥12 months.

Seven patients experienced a total of 402 NSBs in the on-demmporary comprehensive development program evaluating pdVWF/FVIII across all ages demonstrates long-term safety and efficacy for treatment and prevention of bleeds in patients with severe VWD, supporting the benefit-risk profile of pdVWF/FVIII.
The aim of this study was to assess the magnitude of anemia and its associated factors among pregnant women attending antenatal care (ANC) at Dilla University referral Hospital, South Ethiopia.

An institution-based cross-sectional study was conducted from January to February 2019, among 373 pregnant women who attended antenatal care at Dilla University referral hospital. Socio-demographic factors, nutritional, medical and obstetric information of the study participants were collected using a structured questionnaire. Hemoglobin was measured using a hemacue machine, and fecal specimens were examined to detect intestinal parasites. Bivariate and multiple variable binary logistic regressions were used to identify predictors of anemia. A p-value less than 0.05 was used to declare statistical significance.

Overall prevalence of anemia was 28.7%, of which 19.6% had mild anemia. Decreased odds of anemia were found in women with good nutritional status (MUAC ≥24 cm) (AOR= 0.07 95% CI 0.03-0.1), iron supplementation (AOR=0.06 95% CI 0.02-0.15) and birth spacing ≥2 yrs (AOR=0.03 95% CI 0.009-0.45). However, increased odds of anemia were seen in pregnant women with intestinal parasites (AOR=6.11 95% CI 7.70-37.0).

The magnitude of anemia among pregnant women was found to be a moderate public health problem. Iron supplementation, good nutritional status (MUAC> 24 cm), and birth spacing reduce the odds of anemia. But having intestinal parasites was found to increase the likelihood of anemia during pregnancy. Counseling on birth spacing, strengthening iron supplementation, and intestinal parasite management during pregnancy should be given due emphasis.
24 cm), and birth spacing reduce the odds of anemia. But having intestinal parasites was found to increase the likelihood of anemia during pregnancy. Counseling on birth spacing, strengthening iron supplementation, and intestinal parasite management during pregnancy should be given due emphasis.
Surgery is the standard treatment for early-stage non-small cell lung cancer (NSCLC), including ground-glass opacity (GGO)-type lung cancer. However, some patients are inoperable or refuse to undergo surgery. To explore whether proton beam therapy (PBT) can be an alternative to surgical resection in these patients, this study aimed to examine the retrospective treatment outcomes of patients with GGO-type lung cancer who underwent PBT.

Patients with stage I NSCLC and GGOs who underwent PBT at the Medipolis Proton Therapy and Research Center (Kagoshima, Japan) between April 2011 and September 2015 were included. Patients were treated with a total dose of 66 GyE delivered in 10 fractions. Survival curves were calculated using the Kaplan-Meier method, and treatment-related adverse events (AEs) were assessed.

A total of 48 patients (median age 70.9 ± 9.2 years; men 54.2%) were analyzed, among whom 53 tumors were observed. The 3-year overall survival rate after PBT was 91.7% (95% confidence interval [CI], 79.3-96.8%), the 3-year disease-free survival rate was 85.4% (95% CI 71.8-92.8%), and the 3-year local control rate among 53 tumors was 92.5% (95% CI 81.1-97.1%). During the 3-year follow-up period, 4 patients died, and 3 survived despite recurrence or metastasis. Common AEs were radiation pneumonitis (89.6%), rib fracture (27.1%), and cough (27.1%). selleck products None of the patients developed grade ≥3 treatment-related AEs.

The results of this study suggest that PBT may be a promising alternative for patients with GGO-type lung cancer when surgical resection is not feasible, with excellent survival outcomes and tolerable treatment-related AEs.
The results of this study suggest that PBT may be a promising alternative for patients with GGO-type lung cancer when surgical resection is not feasible, with excellent survival outcomes and tolerable treatment-related AEs.Mutations in the epidermal growth factor receptor (EGFR) are common amongst those with non-small cell lung cancer and represent a major factor in treatment decisions, most notably in the advanced stages. Small molecule tyrosine kinase inhibitors (TKIs) that target the EGFR, such as erlotinib, gefitinib, icotinib, afatinib, dacomitinib and osimertinib, have all shown to be effective in this setting. Osimertinib, a third-generation EGFR TKI, is a favorable option, but almost all patients develop resistance at some time point. There are no effective treatment options for patients who progress on osimertinib, but ongoing trials will hopefully address this unmet need. The aim of this review is to provide a comprehensive review of the data with EGFR TKIs, management of the toxicities and the ongoing trials with this class of agents.
Having multiple chronic conditions (MCC) is the most common health condition in older US adults of which Blacks are disproportionally affected. The management of each condition presents many challenges. Blacks in the US frequently cite spirituality as facilitator to well-being. More information is needed to understand the many aspects of spirituality that older Black patients use to manage MCCs.

In the current study, focus groups were conducted with 30 black men and women with MCCs to examine how spirituality can be incorporated into a mobile health intervention designed to increase chronic disease self-management (CDSM) skills by improving health literacy. Groups discussed spiritual practices used to facilitate CDSM and their perceptions about mobile technology use.

Inductive thematic analysis suggested that a chronic disease wellness plan that acknowledges the relationship between spirituality and health was preferred by most participants. Additionally, the desire for mobile health (mHealth) among this group points to an opportunity for intervention.
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