Notes

[Study about anti-inflammatory action as well as system regarding indolealkylamines inside toad skin upon LPS-activated neutrophils].
The PRE.M.I.S.E. project provides standardized data collection for a specific radiation therapy technique, such as SRT. #link# Future aims are including other centers and validating an extracranial SRT ontology.
We sought to determine the safety profile of a therapeutic candidate composed of the released molecules from a combination of human adipose-derived mesenchymal stem cells and fibroblasts. Although stem cells, their progenitor cells and the molecules that are released from these cells have some demonstrated therapeutic value, much more needs to learn about the efficacy, mechanism of action and the safety profiles of these stem cell-based therapeutics.

A number of cellular,
,
and human studies were performed to analyze cellular, tissue and systemic safety profiles of the combinatorial product.

At the levels tested in this study, ranging from demonstrated therapeutic doses to supratherapeutic doses, the combinatorial product demonstrated an excellent safety profile in all
, cellular, tissue and systemic studies.

We found evidence that a therapeutic candidate composed of the molecules released from human adipose-derived mesenchymal stem cells and human fibroblasts has an excellent safety profile, and that the product warrants further studies for safety and efficacy where dosing may include topical application, injection and oral application.
We found evidence that a therapeutic candidate composed of the molecules released from human adipose-derived mesenchymal stem cells and human fibroblasts has an excellent safety profile, and that the product warrants further studies for safety and efficacy where dosing may include topical application, injection and oral application.Granulomatous prostatitis (GP) is an unusual and benign inflammatory condition of the prostate, where autoimmunity has been recognized as a key factor in the pathogenesis of GP in a subset of patients. Clinically, GP poses diagnostic challenges as it may strongly mimic prostate cancer from a clinical, biochemical and radiological point of view. The occurrence of GP in patients suffering from psoriasis, a systemic autoimmune disease, has never been investigated. We describe the case of GP in a patient with psoriatic arthritis presenting with an increased prostate specific antigen level, and evidence of a nodular lesion visualized by prostate multiparametric magnetic resonance imaging, which was highly suspicious for aggressive prostate cancer.IL-27 is a pleiotropic cytokine capable of influencing both innate and adaptive immune responses. With anti- and pro-inflammatory activity, IL-27 exerts its opposing effects in a cell-dependent and infectious context-specific manner. Upon pathogenic stimuli, IL-27 regulates innate immune cells, such as monocytes, dendritic cells, macrophages and neutrophils. Immune responses involving these innate cells that are negatively regulated by IL-27 signaling include inflammatory cytokine production, phagolysosomal acidification following phagocytosis, oxidative burst and autophagy. IL-27 signaling is crucial in maintaining the subtle balance between Th1 and Th2 immunity, in which protective inflammation is upregulated within the early stages of infection and subsequently downregulated once microbial growth is controlled. The immunomodulatory effects of IL-27 provide promising therapeutic targets for multiple disease types.
This paper reports on the antimycobacterial activity of the oleoresins and extracts obtained from
spp.

The minimum inhibitory concentration(MIC)and fractional inhibitory concentration index techniques helped to evaluate the effect of these oleoresins and extracts against six strains of mycobacteria that cause tuberculosis.

Among the assayed oleoresins and plant extracts, the
,
,
and
oleoresins provided the lowest MIC values against some of the tested strains. The combination of
spp. samples with isoniazid did not evidence any synergistic action. Some
spp. oleoresins may represent a future source for the discovery of new antimycobacterial drugs due to their low MIC values.
Among the assayed oleoresins and plant extracts, the Copaifera langsdorffii, Copaifera duckei, Copaifera reticulata and Copaifera trapezifolia oleoresins provided the lowest MIC values against some of the tested strains. The combination of Copaifera spp. samples with isoniazid did not evidence any synergistic action. Some Copaifera spp. oleoresins may represent a future source for the discovery of new antimycobacterial drugs due to their low MIC values.Albert Roger Milla speaks to Joseph Martin, Managing Editor Milla is a former international football player for the Cameroon national team. More recently he is the president of the Noma Fund, an association aiming to completely eradicate Noma disease created by Milla, Joseph-Antoine Bell and Georges-Barthélémy Nko'Ayissi. Find out more about the disease, the association and the president behind the project in this interview.
We aimed to investigate
gene expression pattern and to explore its methylation heterogeneity in chronic lymphocytic leukemia (CLL).

Eighty one CLL patients and 75 healthy subjects were enrolled and prognostic evaluation of patients was assessed.
q-realtime PCR was performed using Applied Biosystems, TaqMan gene expression assay.
gene-specific CpG methylation was investigated in real time using pyrosequencing technology.

was differentially expressed in CLL patients. The CpG sites-1, 2 and 3 showed significantly higher mean levels than healthy controls (p=<0.001, 0.007 and 0.009). Significant association between CpG site-1 and CLL has been detected using age-adjusted logistic regression (p<0.001).

Hypermethylation at
gene CpG sites (1,2,3) is a characteristic feature in CLL.
Hypermethylation at ITGA4 gene CpG sites (1,2,3) is a characteristic feature in CLL.
We examined the utility of the rs924607 TT genotype of the
(
) as a potential biomarker for predilection toward vincristine-induced peripheral neuropathy in children treated for acute lymphoblastic leukemia.

We conducted a random-effects meta-analysis of data from four studies comprising 817 patients. We tested for an association using a recessive model where a one-sided p-value <0.05 was considered statistically significant.

We were unable to confirm the association between the rs924607 TT genotype and neurotoxicity (odds ratio 1.99; p=0.16; 95% CI 0.76-5.25) in our global meta-analysis. Analysis of the continuation phase (following induction) studies showed significantly higher odds for neuropathy in
rs924607 TT homozygotes (odds ratio 2.28; p=0.02; 95% CI 1.16-6.87).
We were unable to confirm the association between the rs924607 TT genotype and neurotoxicity (odds ratio 1.99; p = 0.16; 95% CI 0.76-5.25) in our global meta-analysis. Analysis of the continuation phase (following induction) studies showed significantly higher odds for neuropathy in CEP72 rs924607 TT homozygotes (odds ratio 2.28; p = 0.02; 95% CI 1.16-6.87).
Immune-related adverse events are associated with efficacy of immune checkpoint inhibitors (ICIs). We hypothesize that immune-mediated thrombocytopenia could be a biomarker for response to ICIs.

This retrospective study included 215 patients with metastatic malignancies treated with ICIs. Patients were stratified by nadir platelet count. Outcomes of interest were progression-free survival and overall survival.

On multivariate analysis, grade 1 thrombocytopenia was positively associated with overall survival compared with patients who did not develop thrombocytopenia (hazard ratio [HR]= 0.28 [95% CI 0.13-0.60]; p=0.001), while grade 2-4 thrombocytopenia was not (HR=0.36 [95% CI 0.13-1.04]; p=0.060). There was no association between degree of thrombocytopenia and progression-free survival.

Follow-up studies are warranted to substantiate the predictive significance of thrombocytopenia in patients receiving ICIs.
Follow-up studies are warranted to substantiate the predictive significance of thrombocytopenia in patients receiving ICIs.Investment in biomedical research is believed to drive economic growth and increase human capital, leading to increased productivity and sustainability. Unfortunately, such positive impacts are not palpable among the resource-poor countries. This can be attributed to the poor quality of research findings and the reliability of findings, which often are rarely translated to impactful products or decisions. While GLPG2222 are making considerable efforts to improve the quality of research through increased funding, as well as sponsorship and training of scholars in technologically advanced institutions. This is in order for the transfer of knowledge to improve the livelihood of its citizens. However, there is still need for the private multinational organizations to support this course.We report a Japanese girl with mild xeroderma pigmentosum group D neurological disease. She had short stature, cataracts, intellectual disability, and mild skin symptoms. However, she was not clinically diagnosed. Using whole-exome sequencing, we identified compound heterozygous pathogenic variants in ERCC2. In the future, the patient may develop skin cancer and her neurological symptoms may progress. link2 Early genetic testing is necessary to clarify the cause of symptoms in undiagnosed patients.[This corrects the article DOI 10.1002/nop2.486.].[This corrects the article DOI 10.1002/nop2.403.].
A growing proportion of older people in Germany receive long-term care from informal and professional caregivers at home. Their personal assessment of the individual care situation is scarcely considered.

This study aimed to explore the subjective views of care recipients, informal and professional caregivers on the adequacy of care provision in long-term home care arrangements.

Qualitative semi-structured face-to-face interviews were conducted with ten care recipients, ten professional caregivers and eight informal caregivers to capture their perspectives on the adequacy of the care received and delivered. Qualitative content analysis was applied using MAXQDA software.

All groups highlighted that they perceive an
of care, even though their explanations differed. link3 The underprovision was mainly described regarding the quality rather than quantity of services. It occurs especially in interpersonal relationships and social inclusion, where the gap between the self-perceived current situation and the deto the statement that it is currently non-existent or generally impossible. Misprovision of care is experienced as serious whenever the interviewees face the challenge of preserving existing abilities or regaining certain skills.
Τo validate the Greek version of the Dementia Knowledge Assessment Tool 2, the Dementia Attitudes Scale and Confidence in Dementia Scale.

A quantitative cross-sectional design was applied for translation and validation. The STROBE checklist for observational research has been followed to this survey.

Two hundred and twelve students from the School of Psychology (Aristotle University of Thessaloniki). Psychometric properties were assessed through construct validity (principal component analysis), internal consistency (Cronbach's alpha) and convergent validity.

High internal reliability was found for Confidence in Dementia Scale (α=0.85), adequate reliability for Dementia Attitudes Scale (α=0.74) and acceptable reliability for Dementia Knowledge Assessment Tool 2 (α=0.68). Construct validity was satisfactory for Dementia Attitudes Scale (two factors social comfort and knowledge). The convergent validity was supported to this survey. All three tools are reliable and valid to measure knowledge, confidence and attitudes towards dementia in Greek research context.
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