Notes

Endocytic BDNF secretion controlled by simply Vamp3 throughout astrocytes.
Ketamine administration, immediately after (rather than without) reactivation, significantly increased the NOR preference index, thus suggesting an enhanced memory reconsolidation rather than consolidation. Ketamine exerted no significant effect when administered 6 h after reactivation, thereby suggesting 6 h to be an effective time window. ANA-12 administration significantly reduced the ketamine-induced NOR preference index increase, thus suggesting that the blockage of ketamine improves NOR reconsolidation. learn more However, this blockage had no significant effect on the ketamine-induced hippocampal BDNF level increase. In conclusion, acute low-dose ketamine administration improves NOR memory reconsolidation by increasing hippocampal BDNF levels and subsequent BDNF binding to the TrkB receptor.
The atopic march has been studied mostly in White populations, biasing our current paradigms.

To define the atopic march in Black and White children and explore mechanisms for racial differences.

Utilizing the Mechanisms of Progression of Atopic Dermatitis to Asthma in Children (MPAACH) cohort (N=601), we assessed longitudinal sensitization, food allergy, allergic rhinitis, risk of asthma development (through the Pediatric Asthma Risk Score), SCORAD, transepidermal water loss (TEWL), skin filaggrin (FLG) expression, exposures and genetic heritability to define AD progression endotypes in Black and White children.

White MPAACH children were more likely to be sensitized to aero and food allergens (p=0.0001) and over 3-times more likely to develop food allergy (FA) and/or allergic rhinitis (AR) without asthma risk (p<0.0001). In contrast, Black children were over 6-times more likely to proceed to high asthma risk without FA, sensitization, or AR (p<0.0001). White children had higher lesional and no despite a more intact skin barrier, and less sensitization, FA and AR. White children have less asthma risk, despite a more dysfunctional skin barrier, and more FA, AR and sensitization. The observed racial differences are likely due, in part, to increased genetic heritability for asthma risk and harmful environmental exposures in the Black children. Collectively, our findings provide a new paradigm for the atopic march that is inclusive of Black children.
Cannabinoids modulate the activation of immune cells and physiological processes in the lungs. Group-2 innate lymphoid cells (ILC2)s are central players in type-2 asthma, but how cannabinoids modulate ILC2 activation remains to be elucidated OBJECTIVE Our goal is to investigate the effects of cannabinoids on ILC2s and their role in asthma.

A combination of Cannabinoid receptor (CB)2 KO mice, CB2 antagonist and agonist were used in the mouse models of IL-33, IL-25 and Alternaria alternata ILC2-dependent airway inflammation, and RNA sequencing was performed to assess transcriptomic changes in ILC2s. Humanized mice were used to assess the role of CB2 signaling in human ILC2s.

We here provide evidence that CB2 signaling in ILC2s is important for the development of ILC2-driven airway inflammation in both mice and human. We showed that both naïve and activated murine pulmonary ILC2s express CB2. CB2 signaling did not affect ILC2 homeostasis at steady state, but strikingly stimulated ILC2 proliferation and function upon activation. As a result, ILC2s lacking CB2 induced lower lung inflammation, as we made similar observations using a CB2 antagonist. Conversely, CB2 agonism remarkably exacerbated ILC2-driven airway hyperreactivity and lung inflammation. link2 Mechanistically, transcriptomic and protein analysis revealed that CB2 signaling induced CREB phosphorylation in ILC2s. Human ILC2s expressed CB2, as CB2 antagonism and agonism showed opposing effects on ILC2 effector function and development of airway hyperreactivity in humanized mice.

Collectively, our results define CB2 signaling in ILC2s as an important modulator of airway inflammation.
Collectively, our results define CB2 signaling in ILC2s as an important modulator of airway inflammation.
Prior studies investigating the effect of socio-economic status (SES) on asthma healthcare outcomes have been heterogeneous in their populations studied and methodologies employed.

To systematically synthesize evidence investigating the impact of SES on asthma healthcare utilization, exacerbations and mortality.

We searched Embase, Medline and Web of Science for studies reporting differences in primary care attendance, exacerbations, emergency department (ED) attendance, hospitalization, ventilation / intubation, readmission and asthma mortality by SES. Study quality was assessed using the Newcastle Ottawa Scale and meta-analyses conducted using random-effects models. We conducted several pre-specified subgroup analyses, including by healthcare system (insurance-based vs. universal government funded) and time-period (pre-2010 vs. post-2010).

61 studies, comprising 1,145,704 patients, were included. Lower SES was consistently associated with increased secondary healthcare utilization including ED attenve substantially increased secondary care healthcare utilization. We found evidence suggestive of increased exacerbations and mortality risk although confidence intervals were wide. These disparities have been consistently reported worldwide, including within countries offering universally funded healthcare systems.Numerous neurological, developmental, and psychiatric conditions demonstrate impaired face recognition, which can be socially debilitating. These impairments can be caused by either deficient face perception or face memory mechanisms. Though there are well-validated, sensitive measures of face memory impairments, it currently remains unclear which assessments best measure face perception impairments. A sensitive, validated face perception measure could help with diagnosing causes of face recognition deficits and be useful in characterizing individual differences in unimpaired populations. Here, we compared the computerized Benton Face Recognition Test (BFRT-c) and Cambridge Face Perception Test (CFPT) in their ability to differentiate developmental prosopagnosics (DPs, N = 30) and age-matched controls (N = 30). Participants completed the BFRT-c, CFPT, and two additional face perception assessments the University of Southern California Face Perception Test (USCFPT) and a novel same/different face matching test (SDFMT). Participants were also evaluated on objective and subjective face recognition tasks including the Cambridge Face Memory Test, famous faces test, and Prosopagnosia Index-20. We performed a logistic regression with the perception tests predicting DP vs. control group membership and used multiple linear regressions to predict continuous objective and subjective face recognition memory. Our results show that the BFRT-c performed as well as, if not better than, the CFPT, and that both tests clearly outperformed the USCFPT and SDFMT. Further, exploratory analyses revealed that face lighting-change conditions better predicted DP group membership and face recognition abilities than viewpoint-change conditions. Together, these results support the combined use of the BFRT-c and CFPT to best assess face perception impairments.Autistic individuals show enhanced perceptual functioning on many behavioral tasks. Neurophysiological evidence also supports the conclusion that autistic individuals utilize perceptual processes to a greater extent than neurotypical comparisons to support problem solving and reasoning; however, how atypicalities in early perceptual processing influence subsequent cognitive processes remains to be elucidated. The goals of the present study were to test the relationship between early perceptual and subsequent cognitive event related potentials (ERPs) and their relationship to levels of autism traits. 62 neurotypical adults completed the Autism Spectrum Quotient (AQ) and participated in an ERP task. Path models were compared to test causal relationships among an early perceptual ERP (the P1 component), a subsequent cognitive ERP (the N400 effect), and the Attention to Detail subscale of the AQ. link3 The size of participants' P1 components was positively correlated with the size of their N400 effect and their Attention to Detail score. Model comparisons supported the model specifying that variation in Attention to Detail scores predicted meaningful differences in participants' ERP waveforms. The relationship between Attention to Detail scores and the size of the N400 effect was significantly mediated by the size of the P1 effect. This study revealed that neurotypical adults with higher levels of Attention to Detail show larger P1 differences, which, in turn, correspond to larger N400 effects. Findings support the Enhanced Perceptual Functioning model of autism, suggesting that early perceptual processing differences may cascade forward and result in modifications to later cognitive mechanisms.Conidiobolus lunulus is a recently described entomophthoralean species isolated from leaf-cutter ants. This fungus discharges not only primary but also secondary conidia and microconidia of different shapes. Because nothing was known about the biology of the fungus, and its interactions with hosts, we first evaluated if its pathogenicity against leaf-cutter ants changes with the fungal age (time grown in vitro), and if it is related to the conidial structures produced. Afterwards, we tested its virulence at three combinations of temperature and relative humidity. In addition, we noted all visible causes of death by recovering different microorganisms from the dead, non-sterilized, ants to evaluate C. lunulus virulence when pathogens carried naturally by the ants were present. Finally, we used the conditions that lead to the highest mortality to evaluate fungal virulence to other host species, including non-leaf-cutter ants. Results indicated that C. lunulus was pathogenic from a culture age of 1 to 5 days, with a peak at 2-days-old, from which we registered median lethal times of 1-2 days and 85% of the cadavers with fungal conidiation. Our results suggest that primary conidia and moon-shaped microconidia were infective. Evaluations of mortality using 2-days-old cultures on several leaf-cutter ant colonies showed 1) significantly faster mortality of C. lunulus inoculated ants in comparison to controls, 2) significantly greater and faster mortality at 23.7 °C than at 21.2 °C, 3) significantly higher and faster mortality at 88% than at 57% RH, and 4) a significant reduction of other pathogens in C. lunulus inoculated ants in comparison to controls. C. lunulus was highly specific to leaf-cutter ants, as hardly any increase in mortality was observed on inoculated ants, and no conidia were recorded on cadavers of the other three non-leaf-cutter ant species tested. Our results highlight that C. lunulus is a very promising biological control agent against leaf-cutter ants.This review article summarizes advances in computational chemistry and cheminformatics methods and techniques that are used or have potential for use in reducing health and environmental impacts of Chemical Warfare Agents (CWA). These methods, include, but are not limited to, predictive modeling, data mining and virtual screening, similarity searching, molecular docking and dynamics and are briefly presented here. Applications of these in silico approaches, specifically for the protection of personnel and civilians against CWA, but also beyond, are discussed. CWA include toxic chemicals that can cause death, injury, or temporary incapacitation through their chemical action. CWA impose a significant worldwide threat and as such, destruction, remediation as well as protection measurements need to be carefully designed. Towards this goal computational chemistry and cheminformatics can play a key role specifically as far as decontamination, risk assessment and risk management are concerned. Among the wide range of in silico techniques applied for CWA, specific previously published paradigms are presented, including toxicity and property prediction, CWA simulant identification and CWA detoxification.
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