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Clinical total result right after nivolumab used as a third-line answer to unresectable superior gastric cancer malignancy along with peritoneal distribution: An instance report.
Polarization-controlled coherent Raman spectroscopy is used as a high-throughput method to characterize the anisotropic nature of a molecular system, such as the molecular orientation distribution. However, optical birefringence originating from the molecular anisotropy can cause the observed Raman spectrum to be significantly distorted, making it extremely challenging to obtain quantitative information from polarization Raman measurements. Here, the birefringence effect on the signal intensity and the spectral shape of a polarization-controlled coherent anti-Stokes Raman scattering (CARS) is theoretically described using a uniaxially symmetrical model system. Due to the complexity, the effect of phase delay in the incident lights is not considered but only that of the generated CARS signal is considered. A new analytical method is presented to eliminate the birefringence contribution from polarization-controlled CARS data by analyzing polarization intensity profiles and retrieving the resonant Raman susceptibility spectra. This method is tested with two sets of polarization-controlled CARS data simulated with various combinations of symmetries of multiple underlying Raman modes. The analysis result clearly demonstrates that the effect of birefringence can be corrected for polarization-controlled CARS data and the symmetry tensor elements of all underlying Raman modes can be quantitatively characterized.A symmetrical demodulation method is developed for the recovery of dynamic signals. Extrinsic Fabry-Perot interferometers (EFPIs) with different cavity lengths can be interrogated by a same demodulator. In the demodulation technique, three interferometric signals are introduced by selecting three specified laser wavelength, two of the three signals are symmetrical about the third signal. The dynamic signal is recovered by the proposed method from the three interferometric signals. EFPI sensors in a wide cavity length range (>1000 µm) can be demodulated without dead zone. The calculated amplitude error of the demodulated signal is less than 0.25% with the cavity length in the 20-1005 µm range. The proposed demodulation technique is adapted to the measurement of EFPIs with unsteady cavity lengths and unknown cavity lengths.Two coupled exciton-polariton condensates (EPCs) in a double-well photonic potential are suggested to form the optical Josephson oscillation (JO) whose dependences on the pump arrangement, the potential geometry, and the exciton-photon detuning are studied through the Gross-Pitaevskii equations. When the pump detuning is slightly positive with respect to the polariton energy and the phase difference between the two EPCs is near π/2 (both are controlled by the pump beams), the system demonstrates the optical JO. The optical JO tunneling strength (J) depends on the distance (d) and barrier (Λ) between the two wells, for which an empirical formula is fitted, i.e., J≈0.42exp⁡(-d Λ/18.4) with the energy and length units in meV and μm. Since the double-well potential adopted is general, this fitting relation can show a guidance in practice for designing the optical devices based on the optical JO.This work investigates the excitation of dense comb-like enhanced leaky mode resonance (eLMR) in tilted fiber Bragg grating (TFBG) integrated with indium tin oxide (ITO) nanocoating. see more The ITO overlay leads to a large reduction in mode loss and a great increase of propagation length for s-polarized leaky modes, which means the leaky modes become guided. The guidance of leaky modes enhances significantly the interaction with the core guided mode, which leads to the generation of strong dense comb-like eLMR. The results show that the ultra-narrow eLMR bands present promising sensing performance with an extended measurement range and provide advantages of high Q measurement over the case of surface plasmon resonance (SPR) and lossy mode resonance (LMR). The similarities and differences between the eLMR and SPR and LMR are also discussed. This study offers new opportunities to develop eLMR-based multifunctional fiber-optic devices with high performance.We demonstrated a high-speed 1×2 single-input and multiple-output (SIMO) diffuse-line-of-sight (diffuse-LOS) ultraviolet-C (UVC) solar-blind communication link over a distance of 5 meters. To approach the Shannon limit and improve the spectral efficiency, we implemented probabilistically shaped discrete multitone modulation. As compared to a single-input and single-output (SISO) counterpart, we observed significant improvement in the SIMO link in terms of the angle of view of the receiver and the immunity to emulated weather condition. A wide angle of view of ± 9° is achieved in the SIMO system, with up to a 1.09-Gbit/s achievable information rate (AIR) and a minimum value of 0.24 Gbit/s. Moreover, the bit error rate of the SIMO link in emulated foggy conditions is lowered significantly when compared to that of the SISO link. This work highlights the practicality of UVC communication over realistic distances and in turbulent environments to fill the research gap in high-speed, solar-blind communication.Over the past years, ultrafast lasers with average powers in the 100 W range have become a mature technology, with a multitude of applications in science and technology. Nonlinear temporal compression of these lasers to few- or even single-cycle duration is often essential, yet still hard to achieve, in particular at high repetition rates. Here we report a two-stage system for compressing pulses from a 1030 nm ytterbium fiber laser to single-cycle durations with 5 µJ output pulse energy at 9.6 MHz repetition rate. In the first stage, the laser pulses are compressed from 340 to 25 fs by spectral broadening in a krypton-filled single-ring photonic crystal fiber (SR-PCF), subsequent phase compensation being achieved with chirped mirrors. In the second stage, the pulses are further compressed to single-cycle duration by soliton-effect self-compression in a neon-filled SR-PCF. We estimate a pulse duration of ∼3.4 fs at the fiber output by numerically back-propagating the measured pulses. Finally, we directly measured a pulse duration of 3.
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