Notes

BMP9 and also BMP10: a pair of shut general quiescence lovers which stick out.
High acrylamide intake was associated with increased risks of ovarian and endometrial cancers in a relatively linear manner, especially among never-smokers. Conversely, little association was observed between acrylamide intake and breast cancer risk, with the exception of premenopausal women. Copyright ©2020, American Association for Cancer Research.BACKGROUND Although the poor prognosis and increasing incidence of pancreatic cancer highlight the need for prevention strategies, few lifestyle risk factors for pancreatic cancer have yet been identified. Soybeans contain various bioactive compounds. However, the association between soy food intake and pancreatic cancer risk remains unknown. METHODS The Japan Public Health Center-based Prospective Study (JPHC Study) is a cohort study conducted in a general Japanese population. To determine the association of soy food intake and pancreatic cancer incidence, we analyzed 90,185 participants who responded to a questionnaire on medical history and lifestyle factors, including dietary factors based on a food-frequency questionnaire in 1995-1998, using Cox proportional hazards models. RESULTS During a median follow-up of 16.9 years, 577 cases of pancreatic cancer were identified. In the multivariate-adjusted model, total soy food intake was statistically significantly associated with an increased risk of pancreatic cancer (hazard ratio [HR] for the highest versus lowest intake quartile 1.48; 95% confidence interval [CI] 1.15-1.92; P-trend = 0.007). Among soy foods, non-fermented soy food intake showed a statistically significant positive association with pancreatic cancer (HR 1.41; 95% CI 1.09-1.81; P-trend = 0.008), whereas fermented soy food intake showed no association (HR 0.96; 95% CI 0.73-1.26; P-trend = 0.982). CONCLUSIONS Higher intake of soy foods, particularly non-fermented soy foods, might increase pancreatic cancer risk. IMPACT This study is the first to report an association between the intake of various soy foods and pancreatic cancer risk. Further studies are required to confirm our findings. Copyright ©2020, American Association for Cancer Research.BACKGROUND This study aimed to assess long-term trends in the incidence of prostate cancer by stage at diagnosis before and after the introduction of population-based PSA screening. METHODS We used data from three population-based cancer registries in Japan. A total of 29,458 malignant prostate cancer cases diagnosed between 1993 and 2014 were used for the analysis. Multiple imputation with chained equations was used to impute a specific stage at diagnosis for cases with "Unknown" and missing status. We estimated the age-standardized incidence rates by stage at diagnosis from 1993 to 2014, and used joinpoint linear regression models to assess changes in trend. RESULTS Joinpoint analyses after imputation showed that localize cancer was stable from 1993 to 2000, followed by a pronounced but insignificant increase through 2003 (from 12.1 per 100 000 in 2001 to 34.1 per 100 000 in 2003), and a significant increase thereafter (Annual Percentage Change, APC4.1%). For regional cancer, the imputed data showed that the increasing trend lasted from 1993 to 2006 (APC12.5%), then levelled off through 2014. For distant prostate cancer, the imputed data showed the increasing trend continued from 1993 to 2004 (APC2.4%), and started to marginally decline thereafter (APC-2.2%). CONCLUSIONS Our study confirmed a significantly rapid increase in localized prostate cancer after the spread of PSA screening in Japan, with a marginal decrease in distant prostate cancer after 2004. IMPACT Evaluation of the effectiveness of PSA screening would require a comprehensive analysis of changes in mortality, survival and treatment practices over time. Copyright ©2020, American Association for Cancer Research.OBJECTIVE To identify variables associated with return visits to the hospital within 7 days after discharge. METHODS We performed a retrospective study of 7-day revisits and readmissions between October 2012 and September 2015 using the Pediatric Health Information System database supplemented by electronic medical record data from a tertiary-care children's hospital. We examined factors associated with revisits among the top 10 most frequent indications for hospitalization using generalized estimating equations. RESULTS There were 736 (4.2%) revisits and 416 (2.3%) readmissions within 7 days. Predictors of 7-day revisits and readmissions included age, length of hospital stay, and presence of a chronic medical condition. In addition, insurance status was associated with risk of revisits and race was associated with risk of readmissions in the bivariate analysis. CONCLUSIONS In this study, we identified patient characteristics that may be associated with a higher risk of early return to the emergency department and/or readmissions. Early identification of this at-risk group of patients may provide opportunities for intervention and enhanced care coordination at discharge. Copyright © 2020 by the American Academy of Pediatrics.A patient undergoes intracranial stent insertion for stent-assisted coiling of a basilar tip aneurysm and left middle cerebral artery aneurysm. A flow diverting stent is also placed across an anterior communicating artery aneurysm. Prior to the procedure, the patient takes dual antiplatelet medications, being aspirin and clopidogrel. Because of the concern regarding in-stent thrombus and thromboembolic complications related to intracranial stenting and the high rate of clopidogrel resistance, preoperative platelet function testing (PFT) was undertaken to ensure platelet inhibition. Protosappanin B price In this case, PFT was performed on a platelet function analyser which demonstrated platelet inhibition. Ten days following the procedure, the patient represented with thromboembolic stroke. Repeat PFT performed with whole blood impedance aggregometry and despite full medication compliance demonstrated clopidogrel resistance. Clopidogrel was then ceased and prasugrel commenced. This case demonstrates the importance of appropriate platelet inhibition in patients with intracranial stents and the controversy surrounding PFT. © BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ.
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