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Collectively, this facile genome-wide PT site detection method directly characterizes the distribution and frequency of DNA modification, facilitating a better understanding of its modification mechanism that can be potentially extended to label DNAs in different species.Reports an error in "When the medium massages perceptions Personal (vs. public) displays of information reduce crowding perceptions and outsider mistreatment of frontline staff" by Jean-Nicolas Reyt, Dorit Efrat-Treister, Daniel Altman, Chen Shapira, Arie Eisenman and Anat Rafaeli (Journal of Occupational Health Psychology, 2022[Feb], Vol 27[1], 164-178). In the original article, changes were needed to the labels under the images in the Appendix. Personal media were mistakenly labeled as public and vice versa. The four legends, from left to right, top to bottom, should be "Low crowding, public medium," "Low crowding, personal medium," "High crowding, public medium," and "High crowding, personal medium." The results and conclusions are unchanged. The online version of this article has been corrected. (The following abstract of the original article appeared in record 2022-30403-003). Crowded waiting areas are volatile environments, where seemingly ordinary people often get frustrated and mistreat frontline staff. Given that crowding is an exogenous factor in many industries (e.g., retail, healthcare), we suggest an intervention that can "massage" outsiders' perceptions of crowding and reduce the mistreatment of frontline staff. We theorize that providing information for outsiders to read while they wait on a personal medium (e.g., a leaflet, a smartphone) reduces their crowding perceptions and mistreatment of frontline staff, compared to providing the same information on a public medium (e.g., poster, wall sign). We report two studies that confirm our theory A field experiment in Emergency Departments (n = 939) and an online experiment simulating a coffee shop (n = 246). Theoretical and managerial implications are discussed. (PsycInfo Database Record (c) 2022 APA, all rights reserved).The open science framework has garnered increased visibility and has been partially implemented in recent years. Open science underscores the importance of transparency and reproducibility to conduct rigorous science. Recently, several journals published by the American Psychological Association have begun adopting the open science framework. CX-5461 in vivo At the same time, the field of psychology has been reckoning with the current sociopolitical climate regarding anti-Blackness and White supremacy. As psychology begins to adopt the open science framework into its journals, the authors underscore the importance of embracing and aligning open science with frameworks and theories that have the potential to move the field toward antiracism and away from the embedded White supremacy value systems and ideals. The present article provides an overview of the open science framework; an examination of White supremacy ideology in research and publishing; guidance on how to move away from these pernicious values; and a proposal on alternate value systems to center equity, diversity, and inclusion with the aim of establishing an antiracist open science framework. (PsycInfo Database Record (c) 2022 APA, all rights reserved).The notion of equality (identity) is simple and ubiquitous, making it a key case study for broader questions about the representations supporting abstract relational reasoning. Previous work suggested that neural networks were not suitable models of human relational reasoning because they could not represent mathematically identity, the most basic form of equality. We revisit this question. In our experiments, we assess out-of-sample generalization of equality using both arbitrary representations and representations that have been pretrained on separate tasks to imbue them with structure. We find neural networks are able to learn (a) basic equality (mathematical identity), (b) sequential equality problems (learning ABA-patterned sequences) with only positive training instances, and (c) a complex, hierarchical equality problem with only basic equality training instances ("zero-shot" generalization). In the two latter cases, our models perform tasks proposed in previous work to demarcate human-unique symbolic abilities. These results suggest that essential aspects of symbolic reasoning can emerge from data-driven, nonsymbolic learning processes. (PsycInfo Database Record (c) 2022 APA, all rights reserved).There has long been interest in how the mind represents numerical magnitude, particularly in the absence of symbols. For humans and nonhuman animals, number represents a core dimension of perceptual experience by which objects in the physical world are delineated. The physical world is also well characterized by other dimensions, many of which covary with number. Yet, the general consensus is that number is perceived independently of other magnitudes that co-occur with it. Here, we present evidence against the independence of number perception. In particular, we use evidence from neuroimaging, computational modeling, visual illusions, and psychophysics to introduce a novel theory of visual number encoding, wherein nonnumerical magnitude information such as cumulative surface area is encoded along with number and sustained throughout visual perception. Moreover, we propose that the experience of number per se reflects the readout of a multidimensional (i.e., integral) representation vis-à-vis selective attention, not the independent encoding of number. (PsycInfo Database Record (c) 2022 APA, all rights reserved).Opioid misuse is a critical public health crisis in the United States that results in over 50,000 deaths per year and a substantial economic burden to society. Human epidemiological data suggest that exposure to stress is one of many risk factors for opioid misuse; however, opioid abusers tend to have multiple risk factors and use other drugs in addition to opioids. To identify causal mechanisms by which stress may increase risk, preclinical animal experiments provide a means to conduct experimental manipulations and maintain precise controls over environmental and drug exposures. The current review examines how stressful experiences alter opioid addiction-related behaviors in animal models, with a focus on how age of stress exposure affects drug outcomes. The findings summarized here suggest that neonatal or adult stress increase behaviors indicative of opioid intake and reward in rodent models, but that adolescent social stress may protect against later opioid addiction-related behaviors, which contradicts human epidemiological literature. We highlight three important areas to consider across this body of literature the species and/or strain used, stressor type, and inclusion of both sexes. Finally, we suggest areas where additional research is warranted. (PsycInfo Database Record (c) 2022 APA, all rights reserved).Herein, a copper-catalyzed, blue-light-induced free radical type ring opening of sulfonium salts with dichalcogenides has been initially developed. The developed method features an inexpensive copper catalyst and a broad substrate scope, affording practical access to alkyl chalcogenides in high yields. This reaction presents a novel ring-opening model of sulfonium salts, which breaks the limitation that only the nucleophilic ring-opening reaction could form C-heteroatom bonds and C-C bonds.Metamaterial-assisted illumination nanoscopy (MAIN) has been proven to be a promising approach for super-resolution microscopy with up to a 7-fold improvement in imaging resolution. Further resolution enhancement is possible in principle, however, has not yet been demonstrated due to the lack of high-quality ultrathin layered hyperbolic metamaterials (HMMs) used in the MAIN. Here, we fabricate a low-loss composite HMM consisting of high-quality bilayers of Al-doped Ag and MgO with a nominal thickness of 2.5 nm, and then use it to demonstrate an ultrathin layered hyperbolic metamaterial-assisted illumination nanoscopy (ULH-MAIN) with a 14-fold imaging resolution improvement. This improvement of resolution is achieved in fluorescent beads super-resolution experiments and verified with scanning electron microscopy. The ULH-MAIN presents a simple super-resolution imaging approach that offers distinct benefits such as low illumination power, low cost, and a broad spectrum of selectable probes, making it ideal for dynamic imaging of life science samples.Gut microbiota modulation might constitute a mechanism mediating the effects of beer on health. In this randomized, double-blinded, two-arm parallel trial, 22 healthy men were recruited to drink 330 mL of nonalcoholic beer (0.0% v/v) or alcoholic beer (5.2% v/v) daily during a 4-week follow-up period. Blood and faecal samples were collected before and after the intervention period. Gut microbiota was analyzed by 16S rRNA gene sequencing. Drinking nonalcoholic or alcoholic beer daily for 4 weeks did not increase body weight and body fat mass and did not changed significantly serum cardiometabolic biomarkers. Nonalcoholic and alcoholic beer increased gut microbiota diversity which has been associated with positive health outcomes and tended to increase faecal alkaline phosphatase activity, a marker of intestinal barrier function. These results suggest the effects of beer on gut microbiota modulation are independent of alcohol and may be mediated by beer polyphenols.Evolution of a non-recombining sex-specific region on the Y (or W) chromosome (NRY) is a key step in sex chromosome evolution, but how recombination suppression evolves is not well understood. Studies in many different organisms indicated that NRY evolution often involves several expansion steps. Why such NRY expansions occur remains unclear, although it is though that they are likely driven by sexually antagonistic selection. This paper describes a recent NRY expansion due to shift of the pseudoautosomal boundary on the sex chromosomes of a dioecious plant Silene latifolia. The shift resulted in inclusion of at least 16 pseudoautosomal genes into the NRY. This region is pseudoautosomal in closely related Silene dioica and Silene diclinis, indicating that the NRY expansion occurred in S. latifolia after it speciated from the other species ~120 thousand years ago. As S. latifolia and S. dioica actively hybridise across Europe, interspecific gene flow could blur the PAR boundary in these species. The pseudoautosomal genes have significantly elevated genetic diversity (π ~ 3% at synonymous sites), which is consistent with balancing selection maintaining diversity in this region. The recent shift of the PAR boundary in S. latifolia offers an opportunity to study the process of on-going NRY expansion.Professional challenges have been documented in broad surveys of neuropsychologists. While previous surveyors have included pediatric neuropsychologists, few, if any, have specifically examined practices among those who primarily work in pediatric inpatient rehabilitation settings. Therefore, the aim of this study was to survey neuropsychologists in this setting. Thirty neuropsychologists from the U.S. and one from Canada that work in inpatient pediatric rehabilitation participated in an online survey. Most respondents (83.3%) billed for their inpatient time. Sixty-four percent indicated that payor type (private vs. public) affected services a moderate amount to a lot; this was primarily due to payor's influence on length of stay. Most providers had productivity expectations (66.7%). Among those that had productivity expectations, three-quarters used "hours billed;" 37.5% were solely or additionally tracked by relative value units (RVUs). The majority of respondents conducted some type of clinical data collection, usually for research purposes.
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