Notes

Epidemic associated with binge-eating dysfunction among kids and young people: a planned out review as well as meta-analysis.
By using an arthroscopic hock, grasper and scissors, the exostosis was removed, and the nearby tear was smoothed with the shaver.

Diagnosis of finger like exostosis is challenging and needs strong clinical suspicion because most of the time, it is not predictable and MRI signs may lead to unclear differential diagnosis. The presence of exostosis give a causative explanation of PHLM horizontal tear especially in absence of clear twisting or direct trauma. It may increase the forward directed pull forces of the nearest part of the meniscus during normal gait and gym exercises.

Fingerlike exostosis and other meniscal malformations should be in mind as rare cases. They may explain the presence of tears in young patients with no clear trauma.
Fingerlike exostosis and other meniscal malformations should be in mind as rare cases. They may explain the presence of tears in young patients with no clear trauma.
The aim of this study was to investigate the relationship between high-risk genotypes of Human Papilloma Virus (HPV) and cancer of different subsites of the oral cavity.

A pooled analysis of five studies included on the International Head and Neck Cancer Epidemiology (INHANCE) Consortium was conducted. HPV 16 and HPV 18 were considered. Adjusted odds ratios (ORs) and corresponding 95 % confidence intervals (CIs) for HPV and each oral cavity subsites were simultaneously estimated using multinomial logistic regression models.

The analysis included 1157 cases and 3272 controls. This study showed a slightly higher prevalence of HPV infection among oral cancer cases than controls. In particular, an increased risk of other and not otherwise specified (NOS) sites within the oral cavity, oral tongue, palate and floor of mouth cancer was observed for overall HPV16 positivity (OR = 1.66, 95 % CI 1.01-2.72; OR = 1.97, 95 % CI 1.36-2.85; OR = 2.48, 95 % CI 1.50-4.11; OR = 2.71, 95 % CI 1.06-6.95, respectively). In particular, HPV16E7 was related to cancer of floor of mouth, oral cavity NOS and palate (OR = 2.71, 95 % CI 1.06-6.95; OR = 3.32, 95 % CI1.53-7.19; OR = 3.34, 95 % CI1.38-8.06). Results were inconsistent for HPV18 due to low prevalence of infection.

Our study suggests that HPV16 infection may increase the risk of developing floor of mouth, gum, tongue, and palate cancers.

Subjects with HPV infection have a higher risk of cancer from all sites of the oral cavity.
Subjects with HPV infection have a higher risk of cancer from all sites of the oral cavity.Nanosecond pulsed electric fields (nsPEFs) may induce differential effects on tumor cells from different disease stages and could be suitable for treating tumors by preferentially targeting the late-stage/highly aggressive tumor cells. In this study, we investigated the nsPEF responses of mouse ovarian surface epithelial (MOSE) cells representing progressive ovarian cancer from benign to malignant stages and highly aggressive tumor-initiating-like cells. We established the cell-seeded 3D collagen scaffolds cultured with or without Nocodazole (eliminating the influence of cell proliferation on ablation outcome) to observe the ablation effects at 3 h and 24 h after treatment and compared the corresponding thresholds obtained by numerically calculated electric field distribution. The results showed that nsPEFs induced larger ablation areas with lower thresholds as the cell progress from benign, malignant to a highly aggressive phenotype. This differential effect was not affected by the different doubling times of the cells, as apparent by similar ablation induction after a synergistic treatment of nsPEFs and Nocodazole. The result suggests that nsPEFs could induce preferential ablation effects on highly aggressive and malignant ovarian cancer cells than their benign counterparts. This study provides an experimental basis for the research on killing malignant tumor cells via electrical treatments and may have clinical implications for treating tumors and preventing tumor recurrence after treatment.Electrical activity and oscillations of cytosolic Ca2+ concentrations ([Ca2+]i) that trigger insulin release in response to glucose are key functions of pancreatic β cells. Although oscillatory Ca2+ signals have been intensively studied in β cells, their lower frequency did not match that of electrical activity. In addition, the measured peak [Ca2+]i did not reach levels that are typically required by synaptotagmins to elicit the release of insulin-containing vesicles in live-cell experiments. We therefore sought to resolve the Ca2+ dynamics in the subplasmalemmal microdomain that is critical for triggering fast exocytosis. Applying total internal reflection fluorescence (TIRF) microscopy in insulin-producing INS-1E and primary mouse β cells, we resolved extraordinary fast trains of Ca2+ spiking (frequency > 3 s-1) in response to glucose exposure. Using a low-affinity [Ca2+]i indicator dye, we provide experimental evidence that Ca2+ spikes reach low micromolar apparent concentrations in the vicinity of the plasma membrane. Analysis of Ca2+ spikes evoked by repeated depolarization for 10 ms closely matched the Ca2+ dynamics observed upon glucose application. To our knowledge, this is the first study that experimentally demonstrates Ca2+ spikes in β cells with velocities that resemble those of bursting or continuously appearing trains of action potentials (APs) in non-patched cells.The formation of fungal biofilm goes through some different states, including monodisperse state, aggregated state, germinated state, hyphal and biofilm. The aggregation of spores is a primary step of fungal biofilm development in aquatic systems. Previous studies on the inactivation of fungi were mostly performed in the monodisperse state of fungal spores and biofilm state, however, the inactivation of aggregated fungal spores is still unclear. In this study, the aggregated characteristics of fungal spores (Aspergillus fumigatus and Aspergillus flavus) at different pH values were firstly studied, and the inactivation efficiency of fungal spores at different aggregation degree by chlorine-based disinfectants was also clarified. IPI-549 The results showed that the aggregation degree of Aspergillus fumigatus was the highest at pH 9.0 while it was the lowest at pH 5.0. Aggregation between fungal spores was mainly mediated by occasional adhesin-adhesin interactions and electrostatic interactions. Compared with monodisperse spores, fungal spores were more resistant to chlorine-based disinfectants with the increase of spore aggregation degree. The inactivation rate constants of Aspergillus fumigatus at 30% and 63% aggregation degree were 1.5- and 4-folds lower than that of monodisperse spores, respectively. The lower proportion of membrane damage and higher intracellular reactive oxygen species level for aggregated spores than monodisperse spores was observed according to the flow cytometric results after chlorine-based disinfectants treatment. The reasons for the lower inactivation efficiency of aggregated spores are as following the protection of outer layer spores and signals between aggregates lead to the increase of resistance for aggregated spores. This study is meaningful for the control of the fungal spores at different states in water.Methane ebullition and contamination are two typical characteristics from lakes, however, these two are generally studied independently. In fact, the exchange of matter and energy between methane bubbles and their surrounding environment can be very active to enhance the contaminant transport. There is limited research on understanding the characteristics and trends of gas ebullition facilitated contaminant emissions in large areas considering water and air as receptors. We herein estimate the transport capacity of methane ebullition for polycyclic aromatic hydrocarbons (PAHs) out of the sediment from global lakes, which may reach an average of 71 (up to 159) t yr-1. Methane bubbles could transfer one third of the total PAH flux from sediments, or equivalent of 1.3-3.0 ng L-1 of additional PAHs, into the water column with the rest going into air, offsetting from 52 to 118% of dry PAH deposition flux into global lakes sediment per year. Given the PAH concentration in lake water is often in the range of 0.1-100 ng L-1, ebullition facilitated PAH flux may increase PAH concentration by a factor of 1.4 to 2.4 until 2,100, being a significant contributor for the PAH increment in lake waters.Quorum sensing (QS) has been extensively studied in pure stains of microorganisms, but the ecological roles of QS in multi-species microbial aggregates are poorly understood due to the aggregates' heterogeneity and complexity, in particular the phosphorus (P) entrapment, a key aspect of element cycling. Using periphytic biofilm as a microbial-aggregate model, we addressed how QS signaling via N-acyl-homoserine-lactones (AHLs) regulated P entrapment. The most-abundant AHLs detected were C8-HSL, 3OC8-HSL, and C12-HSL, are the primary regulator of P entrapment in the periphytic biofilm. QS signaling-AHL is a beneficial molecule for bacterial growth in periphytic biofilm and the addition of these three AHLs optimized polyphosphate accumulating organisms (PAOs) community. Growth promotion was accompanied by up-regulation of pyrimidine, purine and energy metabolism. Both intra- and extra-cellular P entrapment were enhanced in the addition of AHLs. AHLs increased extracellular polymeric substances (EPS) production to drive extracellular P entrapment, via up-regulating amino acids biosynthesis and amino sugar/nucleotide sugar metabolism. Also, AHLs improved intracellular P entrapment potential by regulating genes involved in inorganic-P accumulation (ppk, ppx) and P uptake and transport (pit, pstSCAB). This proof-of-concept evidence about how QS signaling regulates P entrapment by microbial aggregates paves the way for managing QS to enhance P removal by microbial aggregates in aquatic environments.In municipal wastewater treatment plants, some dissolved methane can enter the aerobic bioreactors. This greenhouse gas originates from sewers and return flows from anaerobic sludge treatment. In well-mixed conventional activated sludge reactors, methane emissions are largely avoided because methane oxidizing bacteria consume a large fraction, even without optimizing for this purpose. In this work, the fate of dissolved methane is studied in aerobic granular sludge reactors, as they become increasingly popular. The influence of the characteristic design and operating conditions of these reactors are studied with a mathematical model with apparent conversion kinetics and stripping the separation of feeding and aeration in time, a higher substrate transport resistance, a high retention time of granular biomass and a taller water column. Even for a best-case scenario combining an unrealistically low intragranule substrate transport resistance, a high retention time, a tall reactor, an extremely high influent methane concentration and no oxygen limitation, the methane conversion efficiency was only 12% when feeding and aeration were separated in time, which is lower than for continuous activated sludge reactors under typical conditions. A more rigorous model was used to confirm the limited conversion, considering the multi-species and multi-substrate biofilm kinetics, anoxic methane consumers and the high substrate concentration at the bottom during upward plug flow feeding. The observed limited methane conversion is mainly due to the high concentration that accumulates during unaerated feeding phases, which favours stripping more than conversion in the subsequent aeration phase. Based on these findings, strategies were proposed to mitigate methane emissions from wastewater treatment plants with sequentially operated reactors.
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