Notes

Clinical and -inflammatory features with the European U-BIOPRED grown-up significant asthma attack cohort.
The present study sought to determine which painful and provocative events differentiated those with suicidal ideation from those who attempted suicide. Additionally, it presents a novel way of utilizing the Painful and Provocative Scale (PPES) by looking at items dichotomously as experienced or not experienced, instead of the frequency at which they are experienced.

Participants (N=666) were recruited as part of a large online study seeking to understand suicide risk across multiple high-risk groups (i.e., veterinarians, military service members, transgender individuals, and gun owners) for suicide. Participants in the present study were predominately white, female, and heterosexual.

First, the PPES was examined as a dichotomous measure and results indicate that experiencing physical or sexual abuse, tying a noose, using intravenous drugs, or having injuries that required medical attention were associated with greater odds of attempting suicide; shooting a gun was associated with decreased odds. Next, the PPES was examined as a scale measure and findings indicate that increased exposure to rock climbing, experiencing physical or sexual abuse, or using intravenous drug were associated with increased odds of attempting suicide; while increased exposure to shooting a gun was associated with decreased odds.

The present study adds to the literature on the ideation-to-action framework and provides evidence considering the frequency of experiences using the Painful and Provocative Event Scale may not provide substantial information beyond dichotomous scoring.
The present study adds to the literature on the ideation-to-action framework and provides evidence considering the frequency of experiences using the Painful and Provocative Event Scale may not provide substantial information beyond dichotomous scoring.Critical drawbacks, including sluggish redox kinetics and undesirable shuttling of polysulfides (Li2 Sn , n = 4-8), seriously deteriorate the electrochemical performance of high-energy-density lithium-sulfur (Li-S) batteries. Herein, these challenges are addressed by constructing an integrated catalyst with dual active sites, where single-atom (SA)-Fe and polar Fe2 N are co-embedded in nitrogen-doped graphene (SA-Fe/Fe2 N@NG). The SA-Fe, with plane-symmetric Fe-4N coordination, and Fe2 N, with triangular pyramidal Fe-3N coordination, in this well-designed configuration exhibit synergistic adsorption of polysulfides and catalytic selectivity for Li2 Sn lithiation and Li2 S delithiation, respectively. These characteristics endow the SA-Fe/Fe2 N@NG-modified separator with an optimal polysulfides confinement-catalysis ability, thus accelerating the bidirectional liquid-solid conversion (Li2 Sn ↔Li2 S) and suppressing the shuttle effect. Consequently, a Li-S battery based on the SA-Fe/Fe2 N@NG separator achieves a high capacity retention of 84.1% over 500 cycles at 1 C (pure S cathode, S content 70 wt%) and a high areal capacity of 5.02 mAh cm-2 at 0.1 C (SA-Fe/Fe2 N@NG-supported S cathode, S loading = 5 mg cm-2 ). It is expected that the outcomes of the present study will facilitate the design of high-efficiency catalysts for long-lasting Li-S batteries.Management of patients with temporomandibular disorders (TMD) appears to be more challenging than for other dental conditions. This study aimed to explore the decision-making process in TMD management, and thereby to conceptualize the decision-making process in dentistry. Individual semi-structured interviews were conducted during 2018 and 2019 with a purposive sample of 22 general dental practitioners from the Public Dental Healthcare Services and private practices in the Region of Västerbotten, Northern Sweden. The interviews were analysed using the Grounded Theory approach of Charmaz. Data analysis resulted in the core category 'Combining own competence and others' expectations in the desire to do the right thing'. The dentists showed interest in and a desire to apply professional knowledge, but also reflected on challenges and complexity in the decision-making process for TMD. The challenges were primarily related to organisational factors and lack of self-confidence. This identifies a need for re-organisation of daily clinical management in dentistry, and a need for more postgraduate training to improve self-confidence. The complexity of the decision-making process for TMD makes the study findings applicable in other dental situations.In recent years, metabolomics has emerged as a pivotal approach for the holistic analysis of metabolites in biological systems. The rapid progress in analytical equipment, coupled to the rise of powerful data processing tools, now provides unprecedented opportunities to deepen our understanding of the relationships between biochemical processes and physiological or phenotypic conditions in living organisms. However, to obtain unbiased data coverage of hundreds or thousands of metabolites remains a challenging task. Among the panel of available analytical methods, targeted and untargeted mass spectrometry approaches are among the most commonly used. While targeted metabolomics usually relies on multiple-reaction monitoring acquisition, untargeted metabolomics use either data-independent acquisition (DIA) or data-dependent acquisition (DDA) methods. Unlike DIA, DDA offers the possibility to get real, selective MS/MS spectra and thus to improve metabolite assignment when performing untargeted metabolomics. Yet, DDA settings are more complex to establish than DIA settings, and as a result, DDA is more prone to errors in method development and application. Here, we present a tutorial which provides guidelines on how to optimize the technical parameters essential for proper DDA experiments in metabolomics applications. This tutorial is organized as a series of rules describing the impact of the different parameters on data acquisition and data quality. It is primarily intended to metabolomics users and mass spectrometrists that wish to acquire both theoretical background and practical tips for developing effective DDA methods.In this study, the delimitation of intestine segments of koi carp (Cyprinus carpio var. koi) was conducted using a histological approach with the measurements of height of mucosa folds (HF), width of mucosa folds (WF), thickness of muscularis (TM) and cross-sectional area (CSA). According to the change trends for these four parameters, the intestine of the koi carp was divided into anterior intestine, middle intestine and posterior intestine. The locations of the three intestine segments were defined, and their ratios along the entire intestine were accounted for 23.84 ± 1.18%, 46.77 ± 2.29% and 29.39 ± 1.65%, respectively. The anterior intestine had a significantly higher HF, compared with the middle (p .05). The procedure of the delimitation of the koi carp intestine segments can offer useful information for future studies on other fish species. The presented results are meaningful for studies on differential functions of the different intestine segments in fish.Recent advances in polymer chemistry, materials sciences, and biotechnology have allowed the preclinical development of sophisticated programmable nanomedicines and materials that are able to precisely respond to specific disease-associated triggers and microenvironments. AS101 These stimuli, endogenous to the targeted diseases, include pH, redox-state, small molecules, and protein upregulation. Herein, recent advances and innovative approaches in programmable soft materials capable of sensing the aforementioned disease-associated stimuli and responding via a range of dynamic processes including morphological and size transitions, changes in mobility and retention, as well as disassembly are described. In this field generally, the majority of ongoing and past research effort has focused on oncology. Given this interest, examples of the latest innovative approaches to chemo- and immunotherapy treatment strategies for cancer are presented. Moreover, as the field broadens its attention, applications of programmable materials in other diseases are highlighted, with a special focus on cardiovascular disease and diabetes mellitus, where limited attention is paid by the field, but where many promising avenues exist with high potential impact.Sex workers are commonly claimed to be at heightened risk of fatal victimization. Although prior research indicates that the dynamics of sex worker homicides resemble sexual homicides more than nonsexual homicides, little is known about how these types of homicides compare in terms of offending patterns. This study considers a sample of 2,851 single-victim, single-offender homicide cases extracted from a 37-year (1976-2012) US Supplementary Homicide Reports database, and compares the offender, victim, and offender characteristics of 243 sex worker homicides (189 males and 54 females) with those of 2608 sexual homicides (2474 males and 134 females). The findings suggest that the offender, victim, and offense characteristics of general, male-offender, and female-offender sex worker homicides are essentially different from the characteristics of sexual homicides. Logistic regressions further indicate that most offender, victim, and offense characteristics on the occurrence of general and male-offender sex worker homicides were significantly associated with the perpetration of general and male-offender sex worker homicides, with reference to sexual homicides. These findings offer insights relevant to the prioritization of criminal investigative practices.
Lobar emphysema in dogs and cats is caused by bronchial collapse during expiration and subsequent air trapping. Congenital causes such as bronchial cartilage defects or acquired causes such as compressive neoplastic lesions have been reported. Morbidity results from hyperinflation of the affected lung lobe and compression of adjacent thoracic structures.

To describe patient characteristics and imaging findings in dogs and cats with lobar emphysema.

Fourteen dogs and 3 cats with lobar emphysema diagnosed by imaging findings were retrospectively identified from veterinary referral hospital populations over a 10-year period.

Cases that included thoracic radiography, thoracic computed tomography (CT), or both were included. All images were reviewed by a European College of Veterinary Diagnostic Imaging diplomate. Relevant case information included signalment, clinical findings, treatment, and histopathology where available.

Ten of 17 (59%) patients were presented for evaluation of dyspnea and 6 (35%) fof bronchial compression should be considered.Tanshinol (TAN) is a widely used Chinese medicine ingredient with anti-inflammatory activity. The therapeutic effect of TAN in ulcerative colitis (UC) deserves further investigation. DSS induced UC model for mice, and TAN of different concentrations was used for in vivo therapy. Colons length was measured; expression of VLDLR in colonic mucosal tissue was evaluated by qRT-PCR, Western blot and histochemical staining. Besides, normal colorectal mucosal cell line (FHC) was treated with LPS to imitate the inflammatory process of UC in vitro. Different concentrations of TAN treated UC cell model. ELISA and qRT-PCR were applied to examine the concentrations of inflammatory cytokines (TNF-α, IL-6, IL-8, or IL-1β). Flow cytometry and MTT was used to identify the apoptosis and viability of FHC cells, respectively. Afterwards, Western blot was performed to detect the expressions of Bax, Bcl-2, Cleaved caspase-3, and Cleaved caspase-9 in FHC cells. VLDLR was low-expressed in UC tissues as compared to the normal tissue.
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