Notes

The actual m6A-related gene unique with regard to forecasting the particular analysis of breast cancer.
To evaluate the current state, therapeutic benefit and safety of urethral injection of autologous stem cells for the treatment stress urinary incontinence (SUI).

A selective database search of PubMed, the Excerpta Medica dataBASE (EMBASE), Cochrane Library and Google Scholar was conducted to validate the effectiveness of stem cell-based therapy. The search included clinical trials published up until 4 January 2020, written in English, and included cohorts of women and men who had received stem cell-based therapy for SUI. The search used the following keywords in various combinations 'stem cell therapy', 'cell-based therapy for SUI', 'regenerative medicine for SUI', and 'tissue engineering'. The success rates were assessed according to cough test, urodynamics, pad tests, and International Consultation on Incontinence Questionnaire-Urinary Incontinence. The primary endpoint was continence rate to measure objectively the effect of the treatment.

We identified four clinical trials using local injections of e; FPL functional profile length; HUCB human umbilical cord blood stem cell; ICIQ-(QOL)(SF)(UI) International Consultation on Incontinence Questionnaire (Quality of life) (-Urinary incontinence Short Form) (-Urinary Incontinence); IIQ-7 Incontinence Impact Questionnaire-short form; I-QOL Incontinence quality of life questionnaire; ISD intrinsic urinary sphincter deficiency; MDSC muscle-derived stem cell; MUCP maximum urethral closure pressure; NR not reported; Pdet-max maximum detrusor pressure; PVR post-void residual urine volume; Qmax maximum urinary flow; QOL quality of life; RP radical prostatectomy; TNC total nucleated cell; (S)UI (stress) urinary incontinence; UDSCs urine-derived stem cells; UTUS upper tract ultrasonography; VLPP Valsalva leak-point pressure.
To compare the perioperative and pathological outcomes between robot-assisted laparoscopic radical prostatectomy (RALRP) and LRP based on the patient's risk.

The medical records of 588 patients with prostate cancer who underwent RP, using minimally invasive surgery (MIS) techniques (240 LRP and 348 RALRP) by a single surgeon during January 2008 to June 2018 at the Ramathibodi Hospital, were retrospectively reviewed. The patient's risk was classified according to the National Comprehensive Cancer Network (NCCN) Guideline, 2018. The demographic, perioperative, and pathological data of patients were collected. The differences in perioperative and pathological outcomes between LRP and RALRP in each risk classification were assessed using chi-square, Fisher's exact tests and logistic regression, as appropriate.

In terms of positive margins, RALRP had significant advantages in high-risk patients when compared to LRP (adjusted odds ratio 0.46, 95% confidence interval 0.26-0.84), while there were no differences in the low- and intermediate-risk patients. Overall, the patients who underwent RALRP had significant advantages over those who underwent LRP in terms of operative time, estimate blood loss, and blood transfusion rate. While, adjacent organ injury rate and length of hospital stay were similar for both techniques in all subgroup analyses.

MIS techniques appear to be safe, especially RALRP, which has significantly better perioperative outcomes in all subgroups of patient risk classification, and in the high-risk patient group it seems to have better pathological outcomes when compared to LRP.

EBL estimated blood loss; LOS length of hospital stay; PSM positive surgical margin; (L)(O)(RAL)RP (laparoscopic) (open) (robot-assisted laparoscopic) radical prostatectomy; MIS minimally invasive surgery.
EBL estimated blood loss; LOS length of hospital stay; PSM positive surgical margin; (L)(O)(RAL)RP (laparoscopic) (open) (robot-assisted laparoscopic) radical prostatectomy; MIS minimally invasive surgery.
To compare the management of large ureteric stones (>10 mm) with ureterorenoscopy (URS) and laser or pneumatic lithotripsy, and their associated costs.

Our prospective study followed the tenets of the Declaration of Helsinki and included 101 patients with large mid-ureteric stones eligible for URS and lithotripsy, and was conducted between January 2018 and August 2019. TNG260 manufacturer Patients were randomly divided into two groups Group 1 had laser lithotripsy, while the Group 2 had lithotripsy using a pneumatic energy source.

Operative time was significantly longer in cases using pneumatic lithotripsy (
<0.001). The stone-free rate (SFR) on the first postoperative day was 94% and 92.5% for laser and pneumatic lithotripsy respectively, and there were no statistically significant differences in terms of early (day 1) or late (day 30) SFRs between the groups. Complications were classified according to the Clavien-Dindo Grading System, all complications were Grade <III, with no statistically significant difference between the groups (
=0.742). The use of pneumatic lithotripsy had lower treatment costs. The number of auxiliary procedures required to reach a stone-free status was statistically equivalent in both groups.

The type of lithotripsy did not affect the SFR or complications. However, laser lithotripsy was much more expensive than pneumatic lithotripsy.

KUB plain abdominal radiograph of the kidneys, ureters and bladder; SFR stone-free rate; SWL shockwave lithotripsy; URS Ureterorenoscopy; US ultrasonography.
KUB plain abdominal radiograph of the kidneys, ureters and bladder; SFR stone-free rate; SWL shockwave lithotripsy; URS Ureterorenoscopy; US ultrasonography.
To prospectively assess the safety and effectiveness of antegrade mini-percutaneous (miniperc) ureteroscopy (URS) and compare it with the conventional retrograde URS (RURS) approach in treating impacted proximal ureteric stones of 1-2 cm.

The study included 60 patients admitted to the Department of Urology, Alexandria Main University Hospital, presenting with impacted proximal ureteric stones of 1-2 cm. Patients were randomly divided into two groups Group A, were treated with RURS using a semi-rigid or flexible ureteroscope to access the stone; and Group B, were treated by antegrade miniperc URS, were a 14-F renal tract was obtained to pass a ureteric access sheath, then a flexible ureteroscope was used going downwards to the stone. Holmium laser was used for stone fragmentation. A JJ stent was inserted in all cases. Follow-up with non-contrast computed tomography was performed after 2weeks.

Both groups were comparable in terms of patient demographics and stone criteria. The stone-free rate was significne-free rate; (R)URS (retrograde) ureteroscopy.
To compare three groups of patients who underwent uncomplicated ureteroscopic lithotripsy (URSL) and to evaluate whether stenting could be eliminated after the procedure, as there is no consensus about whether a ureteric stent should be placed after uncomplicated ureteroscopy for stone retrieval.

In this randomised clinical trial (NCT04145063) 105 patients underwent uncomplicated URSL for ureteric stones. They were prospectively randomised into three groups Group 1 (34 patients) with a double pigtail ureteric stent, Group 2 (35 patients) with a double pigtail ureteric stent with extraction string, and Group 3 (36 patients) with no ureteric stent placed after the procedure. The outcomes measured were postoperative visual analogue scale (VAS) score for flank pain and dysuria score, urgency, frequency, suprapubic pain, haematuria, analgesia requirement, operative time, re-hospitalisation, and return to normal physical activity.

The mean (SD) operative time was significantly longer in groups 1 and 2 compareAS visual analogue scale.
KUB plain abdominal radiograph of the kidneys, ureters and bladder; URSL ureteroscopic lithotripsy; VAS visual analogue scale.
To investigate complications and treatment failure rates of percutaneous renal cryoablation (PRC) for small renal masses under local anaesthesia and conscious sedation (LACS), to assess the safety and effectiveness of this approach, as PRC is typically performed under general anaesthesia (GA).

We retrospectively reviewed PRC under LACS from 2003 to 2017. We analysed perioperative parameters between patients who successfully underwent PRC under LACS and patients with post-procedural complications or treatment failure (renal mass enhancement after successful intraoperative tumour ablation). Two-sided non-parametric and Fisher's exact tests were performed to compare uncomplicated or disease-free PRC with the complication or treatment failure group, respectively.

A total of 100 PRCs under LACS were performed during the study period. Of these patients, six patients had at least one postoperative complication (6%), and treatment failure was diagnosed in nine patients (9%) after PRC [mean (SD) follow-up of 42.sthesia and conscious sedation; PRC percutaneous renal cryoablation; R.E.N.A.L. Radius, Exophytic/Endophytic, Nearness, Anterior/Posterior, Location.
To summarise the currently available literature and analyse available results of the outcome of intraoperative frozen-section analysis (FSA) on upper urinary tract recurrence (UUTR) after radical cystectomy (RC).

A systematic review of the literature was performed according to the Cochrane Reviews guidelines and in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist. Articles discussing ureteric FSA with RC were identified.

The literature search yielded 21 studies, on which the present analysis was done. The studies were published between 1997 and 2019. There were 10 010 patients with an age range between 51 and 95years. Involvement of the ureteric margins was noted in 2-9% at RC. The sensitivity and specificity of FSA were ~75% and 99%, respectively. Adverse pathology on FSA and on permanent section, prostatic urothelial carcinoma involving the stroma but not prostatic duct, and ureteric involvement on permanent section were all more likely to develtematic Reviews and Meta-Analyses; RC radical cystectomy; (UT)UC (upper tract) urothelial carcinoma; UUT(R) upper urinary tract (recurrence).
To evaluate predictors of prostatic chronic inflammation (PCI) and prostate cancer (PCa) in patients undergoing transperineal baseline random prostatic needle biopsies (BNB).

According to BNB outcomes, patients were divided into four groups cases without PCI or PCa (Control group), cases with PCI only (PCI group), cases with PCa and PCI (PCa+PCI group) and cases with PCa only (PCa group). A multinomial logistic regression model was used to evaluate the association of clinical factors with BNB outcomes. Additionally, clinical factors associated with the risk of PCa in the overall population were investigated using a multivariable logistic regression model (univariate and multivariate analysis).

Overall, 945 patients were evaluated and grouped as follows Control group, 308 patients (32.6%); PCI group, 160 (16.9%); PCa+PCI group, 45 (4.8%); and PCa group, 432 (45.7%). Amongst these, PCa was independently predicted by age (odds ratio [OR] 1.081), prostate specific-antigen level (PSA; OR 1.159), transition znational Society of Urologic Pathology; NIH National Institutes of Health; OR odds ratio; PCa prostate cancer; PCI prostatic chronic inflammation; TGF transforming growth factor; TPV total prostate volume; TZV transition zone volume.
BGG biopsy Gleason Group; BPC biopsy positive (cancer) cores; BMI body mass index; FGF-2 fibroblast growth factor 2; IL interleukin; ISUP International Society of Urologic Pathology; NIH National Institutes of Health; OR odds ratio; PCa prostate cancer; PCI prostatic chronic inflammation; TGF transforming growth factor; TPV total prostate volume; TZV transition zone volume.
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