Notes

Diclofenac Adjusts the Cell Routine Advancement of the Green Alga Chlamydomonas reinhardtii.
6%) had haemodynamically significant stenoses. MRA accuracy was 78.1% (478/612) and 75.6% (464/614), sensitivity 64.7% (161/249) and 77.5% (193/249), and specificity 87.3% (317/363) and 74.2% (271/365) for 2 readers. MRA accuracy was 80.9% and 80.7% for readers 1 and 2, respectively, in patients with severe renal impairment. QISS MRA but not pedal QISS-ASL MRA was considered of diagnostic image quality. Inter-reader agreement was moderate for stenosis (ĸ = 0.60) and diagnostic confidence (ĸ = 0.41). Test-retest reproducibility was high (ĸ = 0.87) and moderate (ĸ = 0.54) for individual readers. CONCLUSIONS Quiescent-interval single-shot MRA has reasonable accuracy in a diabetic PAD population with high burden of disease, providing a non-contrast option in patients with renal impairment. QISS-ASL MRA requires further optimisation to be clinically feasible. © 2020 The Royal Australian and New Zealand College of Radiologists.INTRODUCTION To evaluate the safety and efficacy of minimally invasive percutaneous thermal ablation alone or in combination with cementoplasty for pain palliation and local tumour control of renal cell carcinoma osseous metastases. METHODS Imaging-guided thermal ablation was performed in 59 renal cell carcinoma osseous metastatic tumours in 23 patients (concomitant cementoplasty in 43 tumours) selected following multidisciplinary consultations to achieve local tumour control and pain palliation (75%, 44/59) or pain palliation alone (25%, 15/59) in this retrospective study. Tumour characteristics, procedural details and complications were documented. Pain palliation was assessed using pre- and post-procedural Numeric Rating Scale scores at 1-week, 1-month, 3-month and 6-month time intervals. Pre- and post-procedural cross-sectional imaging was reviewed to assess local tumour control rates at 3-month, 6-month, and 12-month post-treatment time intervals. RESULTS All procedures were technically successful and performed as pre-operatively planned. The median pre- and post-procedural Numeric Rating Scale scores were 8.0 and 3.0 (at all time intervals), respectively (P less then 0.001). Roxadustat HIF modulator Local tumour control rates were 100% (40/40), 100% (36/36) and 85% (28/33) at ≥3 months, ≥6 months and ≥12 months post-procedural time intervals, respectively. There was 1 minor complication (1.7%, 1/59). CONCLUSIONS Percutaneous thermal ablation alone or in combination with cementoplasty is safe and effective for pain palliation and local tumour control of renal cell carcinoma osseous metastases. © 2020 The Royal Australian and New Zealand College of Radiologists.OBJECTIVES To describe haemodynamic resuscitation practices in ED patients with suspected sepsis and hypotension. METHODS This was a prospective, multicentre, observational study conducted in 70 hospitals in Australia and New Zealand between September 2018 and January 2019. Consecutive adults presenting to the ED during a 30-day period at each site, with suspected sepsis and hypotension (systolic blood pressure  less then 100 mmHg) despite at least 1000 mL fluid resuscitation, were eligible. Data included baseline demographics, clinical and laboratory variables and intravenous fluid volume administered, vasopressor administration at baseline and 6- and 24-h post-enrolment, time to antimicrobial administration, intensive care admission, organ support and in-hospital mortality. RESULTS A total of 4477 patients were screened and 591 were included with a mean (standard deviation) age of 62 (19) years, Acute Physiology and Chronic Health Evaluation II score 15.2 (6.6) and a median (interquartile range) systolic blood pressure of 94 mmHg (87-100). Median time to first intravenous antimicrobials was 77 min (42-148). A vasopressor infusion was commenced within 24 h in 177 (30.2%) patients, with noradrenaline the most frequently used (n = 138, 78%). A median of 2000 mL (1500-3000) of intravenous fluids was administered prior to commencing vasopressors. The total volume of fluid administered from pre-enrolment to 24 h was 4200 mL (3000-5661), with a range from 1000 to 12 200 mL. Two hundred and eighteen patients (37.1%) were admitted to an intensive care unit. Overall in-hospital mortality was 6.2% (95% confidence interval 4.4-8.5%). CONCLUSION Current resuscitation practice in patients with sepsis and hypotension varies widely and occupies the spectrum between a restricted volume/earlier vasopressor and liberal fluid/later vasopressor strategy. © 2020 The Authors. Emergency Medicine Australasia published by John Wiley & Sons Australia, Ltd on behalf of Australasian College for Emergency Medicine.Internalization of the "thin ideal" is a risk factor for eating pathology. It is unclear how pervasive the thin ideal is among young Chinese. In the current study, 97 participants reported their subjective willingness to be thin and their eating-disorder-related weight-controlling behaviors, and then finished a picture judgment task to implicitly detect their perception of the importance of thinness to attractiveness. Hierarchical linear modeling was used to analyze the data. Among female participants, 79.59% wanted a thinner body. Participants' level of willingness to be thin correlated positively with frequency of eating-disorder-related weight-controlling behaviors, r = .47, p  less then  .05. In the implicit task, the judgment of others' attractiveness correlated negatively with body mass index (BMI) evaluation, and this relationship was stronger for women's pictures than for men's pictures. Additionally, an individual's willingness to be thin enhanced the relationship between BMI evaluation and attractiveness judgment. The notion "the thinner the better" seems to be widely accepted among young Chinese. © 2020 The Institute of Psychology, Chinese Academy of Sciences and John Wiley & Sons Australia, Ltd.OBJECTIVES Diagnostic shifts in first episode psychosis (FEP) are not uncommon. Many studies examining diagnostic stability use structured diagnostic interviews. Less is known about the stability of FEP diagnoses made clinically. METHODS We conducted a retrospective chart review of patients enrolled in a transdiagnostic FEP clinic. For the 96 patients followed clinically at least 2 years, we compared diagnoses at intake and 24 months. RESULTS Diagnostic stability was high for bipolar disorder (89%), schizoaffective disorder (89%), and schizophrenia (82%). Psychosis not otherwise specified (13%) was more unstable, with limited baseline differences that would enable clinicians to predict who would convert to a primary psychotic vs affective psychotic disorder. CONCLUSIONS Our real-world clinical sample shows that FEP diagnoses, with the exception of unspecified psychosis, are diagnostically stable, even without structured diagnostic interviews. © 2020 John Wiley & Sons Australia, Ltd.Due to the remarkable properties of gold nanoparticles (AuNPs), they have been extensively employed as a potential tool for the diagnosis and treatment of cancers. While the conventional drug delivery system fails to efficiently deliver the chemotherapeutics due to the complexity of tumor microenvironment, people have been seeking alternative nanoparticulate strategy to improve the tumor specificity, the therapeutic index as wells as the pharmacokinetic profile. The nontoxic and nonimmunogenic nature, the high permeability, and superior retention effect of AuNPs provide additional benefits by enabling easy penetration and accumulation of drugs at the tumor sites. Here in this review, we focused on discussing the recent advances regarding the design of acid-responsive AuNPs as well as their applications in drug/gene delivery and imaging in cancer diagnosis and therapy. Particularly, we highlighted the size switch strategies used in the development of acid-responsive AuNPs. This article is categorized under Diagnostic Tools > in vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease. © 2020 Wiley Periodicals, Inc.The tooth defect is a frequently occurring disease within the field of dental clinic. However, the traditional manual restoration for the defective tooth needs an especially long treatment time, and dental computer aided design and manufacture (CAD/CAM) systems fail to restore the personalized anatomical features of natural teeth. Aiming to address the shortcomings of existed methods, this article proposes an intelligent network model for designing tooth crown surface based on conditional generative adversarial networks. Then, the data set for training the network model is constructed via generating depth maps of 3D tooth models scanned by the intraoral. Through adversarial training, the network model is able to generate tooth occlusal surface under the constraint of the space occlusal relationship, the perceptual loss, and occlusal groove filter loss. Finally, we carry out the assessment experiments for the quality of the occlusal surface and the occlusal relationship with the opposing tooth. The experimental results demonstrate that our method can automatically reconstruct the personalized anatomical features on occlusal surface and shorten the treatment time while restoring the full functionality of the defective tooth. © 2020 John Wiley & Sons, Ltd.Drug development guidelines from regulatory authorities provide important information to sponsors on requirements for clinical evidence needed to support approval of new drugs. In the field of Alzheimer's disease (AD), recently published guidelines are available from EU, US, and Japanese regulatory authorities. In this review, these three guidelines are compared and discussed with emphasis on the recommendations provided for demonstration of efficacy in pivotal clinical trials conducted in predementia stages of AD. Similarities and differences are highlighted, and impact for global drug development is discussed in the context of the new International Conference on Harmonization E17 guideline on multiregional clinical trials. The AD field is characterized by significant challenges as, to date, no drug approval precedence exists in predementia AD despite numerous and ambitious efforts to slow the progression of the disease by pharmacologic intervention. Despite these uncertainties regulatory authorities across regions have blazed a trail for proactive multistakeholder collaboration, involvement, and continuous dialogue, setting a positive example on how to foster a supportive environment for development of new and meaningful treatments for patients with AD globally. © 2020 The Authors. Clinical and Translational Science published by Wiley Periodicals, Inc. on behalf of the American Society for Clinical Pharmacology and Therapeutics.BACKGROUND We aimed to assess if quantitative radiomic features can predict programmed death ligand 1 (PD-L1) expression in advanced stage lung adenocarcinoma. METHODS This retrospective study included 153 patients who had advanced stage (>IIIA by TNM classification) lung adenocarcinoma with pretreatment thin section computed tomography (CT) images and PD-L1 expression test results in their pathology reports. Clinicopathological data were collected from electronic medical records. Visual analysis and radiomic feature extraction of the tumor from pretreatment CT were performed. We constructed two models for multivariate logistic regression analysis (one based on clinical variables, and the other based on a combination of clinical variables and radiomic features), and compared c-statistics of the receiver operating characteristic curves of each model to identify the model with the higher predictability. RESULTS Among 153 patients, 53 patients were classified as PD-L1 positive and 100 patients as PD-L1 negative.
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