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Effect of never-ending loop sequence on unzipping regarding short DNA hairpins.
Complex dynamical systems rely on the correct deployment and operation of numerous components, with state-of-the-art methods relying on learning-enabled components in various stages of modeling, sensing, and control at both offline and online levels. This article addresses the runtime safety monitoring problem of dynamical systems embedded with neural-network components. A runtime safety state estimator in the form of an interval observer is developed to construct the lower bound and upper bound of system state trajectories in runtime. The developed runtime safety state estimator consists of two auxiliary neural networks derived from the neural network embedded in dynamical systems, and observer gains to ensure the positivity, namely, the ability of the estimator to bound the system state in runtime, and the convergence of the corresponding error dynamics. The design procedure is formulated in terms of a family of linear programming feasibility problems. The developed method is illustrated by a numerical example and is validated with evaluations on an adaptive cruise control system.The problem of secure finite-horizon consensus control for discrete time-varying multiagent systems (MASs) with actuator saturation and cyber attacks is addressed in this article. A random attack model is first proposed to account for randomly occurring false data injection attacks and denial-of-service attacks, whose dynamics are governed by the random Markov process. The hybrid secure control scheme is developed to mitigate the influence of arbitrary cyber attacks on system performance. Specifically, this article proposes a hybrid control law containing multiple controllers, each of which is designed to counter different types of cyber attacks. By using the stochastic analysis approach, two sufficient criteria are provided to guarantee that the time-varying MASs satisfy the finite horizon H∞ consensus performance. Then, the controller parameters are obtained by solving the recursive linear matrix inequality. The usefulness of the theoretic results presented is demonstrated via a numerical example that contains a performance comparison of different secure control schemes.Deep probabilistic aspect models are widely utilized in document analysis to extract the semantic information and obtain descriptive topics. However, there are two problems that may affect their applications. One is that common words shared among all documents with low representational meaning may reduce the representation ability of learned topics. The other is introducing supervision information to hierarchical topic models to fully utilize the side information of documents that is difficult. To address these problems, in this article, we first propose deep diverse latent Dirichlet allocation (DDLDA), a deep hierarchical topic model that can yield more meaningful semantic topics with less common and meaningless words by introducing shared topics. Moreover, we develop a variational inference network for DDLDA, which helps us to further generalize DDLDA to a supervised deep topic model called max-margin DDLDA (mmDDLDA) by employing max-margin principle as the classification criterion. Compared to DDLDA, mmDDLDA can discover more discriminative topical representations. In addition, a continual hybrid method with stochastic-gradient MCMC and variational inference is put forward for deep latent Dirichlet allocation (DLDA)-based models to make them more practical in real-world applications. The experimental results demonstrate that DDLDA and mmDDLDA are more efficient than existing unsupervised and supervised topic models in discovering highly discriminative topic representations and achieving higher classification accuracy. Meanwhile, DLDA and our proposed models trained by the proposed continual learning approach cannot only show good performance on preventing catastrophic forgetting but also fit the evolving new tasks well.Both objective optimization and constraint satisfaction are crucial for solving constrained multiobjective optimization problems, but the existing evolutionary algorithms encounter difficulties in striking a good balance between them when tackling complex feasible regions. To address this issue, this article proposes a two-stage evolutionary algorithm, which adjusts the fitness evaluation strategies during the evolutionary process to adaptively balance objective optimization and constraint satisfaction. The proposed algorithm can switch between the two stages according to the status of the current population, enabling the population to cross the infeasible region and reach the feasible regions in one stage, and to spread along the feasible boundaries in the other stage. Experimental studies on four benchmark suites and three real-world applications demonstrate the superiority of the proposed algorithm over the state-of-the-art algorithms, especially on problems with complex feasible regions.The ballistocardiogram (BCG), a cardiac vibration signal, has been widely investigated for continuous monitoring of heart rate (HR). Among BCG sensing modalities, a hospital bed with multi-channel load-cells could provide robust HR estimation in hospital setups. In this work, we present a novel array processing technique to improve the existing HR estimation algorithm by optimizing the fusion of information from multiple channels. selleck The array processing includes a Gaussian curve to weight the joint probability according to the reference value obtained from the previous inter-beat-interval (IBI) estimations. Additionally, the probability density functions were selected and combined according to their reliability measured by q-values. We demonstrate that this array processing significantly reduces the HR estimation error compared to state-of-the-art multi-channel heartbeat detection algorithms in the existing literature. In the best case, the average mean absolute error (MAE) of 1.76 bpm in the supine position was achieved compared to 2.68 bpm and 1.91 bpm for two state-of-the-art methods from the existing literature. Moreover, the lowest error was found in the supine posture (1.76 bpm) and the highest in the lateral posture (3.03 bpm), thus elucidating the postural effects on HR estimation. The IBI estimation capability was also evaluated, with a MAE of 16.66 ms and confidence interval (95%) of 38.98 ms. The results demonstrate that improved HR estimation can be obtained for a bed-based BCG system with the multi-channel data acquisition and processing approach described in this work.
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