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Nasal Immunization Using Tiny Compound Mast Cell Activators Improve Defense in order to Co-Administered Subunit Immunogens.
An azide masked amine is used to obtain a cage of lower symmetry that possess one terpy-group in an exo-position. This group can coordinate to iron(ii), yielding selectively an easy to purify Fe(terpy-cage)2 dumbbell. The dumbbell can also be obtained in a one pot reaction, which proceeded without isolation of the exo-functionalized cage.This study was conducted to explore the potential cardioprotective and anti-depressive effects of dichloromethane (DCM) fractions of Morus macroura leaves (L) and stem branches (S) on post-myocardial infarction (MI) depression induced by isoprenaline (ISO) in rats in relation to their metabolites. The study was propped with a UPLC-ESI-MS/MS profiling and chromatographic isolation of the secondary metabolites. Column chromatography revealed the isolation of lupeol palmitate (6) that was isolated for the first time from nature with eight known compounds. In addition, more than forty metabolites belonging, mainly to flavonoids, and anthocyanins groups were identified. The rats were injected with ISO (85 mg kg-1, s.c) in the first two days, followed by the administration of M. macroura DCM-L and DCM-S fractions (200 mg kg-1 p.o) for 19 days. Compared with the ISO exposed rats, the treated rats displayed a reduction in cardiac biomarkers (LDH and CKMB), anxiety, and depressive-like behaviour associated with an increase in the brain defense system (SOD and GSH), neuronal cell energy, GABA, serotonin, and dopamine, confirmed by histopathological investigations. In conclusion, DCM-L and DCM-S fractions' cardioprotective and anti-depressive activities are attributed to their metabolite profile. Therefore, they could serve as a potential agent in amending post-MI depression.Mono-cationic ionic liquids (MILs) have been widely utilized for the treatment of lignocelluloses. However, the hydrophilic property of MILs increases the difficulty of isolating sugars and their reuse, which limits their industrial application. In the present study, a series of dicationic ionic liquids (DILs) were synthesized with totally different di-cations and di-anions. An alternating miscibility of DILs with water was observed depending on the dealing temperature. The functional DILs exhibiting hydrophobic and acidic properties were investigated for the treatment of corn stalk. High yields of sugars were achieved as 27.8% and 31.6% with DIL3 and DIL4, respectively. Cellulosic materials were obtained as 74.3% and 77.8% with DIL1 and DIL2 and 61.2% and 65.7% with DIL3 and DIL4, respectively. Enzymatic reaction was successfully performed with cellulosic materials after the DIL treatment. DILs were recycled and reused with no significant reduction in sugar yields. Hydrophobic DILs are a potentially effective approach to enable the successful decomposition and degradation of lignocellulosic biomass.It is currently known that crosslinking agents can effectively improve the mechanical properties of dentin by crosslinking type I collagen. However, few scholars have focused on the influence of crosslinking agents on the collagen-mineral interface after crosslinking. Analysis of the Fourier transform infrared spectroscopy (FTIR) results showed that hydrogen bonding occurs between the tannic acid (TA) molecule and the collagen. The crosslinking degree of TA to collagen reached a maximum 41.28 ± 1.52. This study used TA crosslinked collagen fibers to successfully induce dentin biomineralization, and the complete remineralization was achieved within 4 days. The crosslinking effect of TA can improve the mechanical properties and anti-enzyme properties of dentin. The elastic modulus (mean and standard deviation) and hardness values of the remineralized dentin pretreated with TA reached 19.1 ± 1.12 GPa and 0.68 ± 0.06 GPa, respectively, which were close to those of healthy dentin measurements, but significantly higher than those of dentin without crosslinking (8.91 ± 1.82 GPa and 0.16 ± 0.01 GPa). The interface energy between the surface of collagen fibers and minerals decreased from 10.59 mJ m-2 to 4.19 mJ m-2 with the influence of TA. The current work reveals the importance of tannic acid crosslinking for dentin remineralization while providing profound insights into the interfacial control of biomolecules in collagen mineralization.Despite extensive research on the matter of corrosion inhibition efficiency, the interactions between the defect structure of the passive layer and the inhibitor molecules still remain poorly understood. In this study, the corrosion inhibition mechanism of ethylenediamine-tetraacetic acid as a carboxylate-based organic inhibitor on steel specimens in simulated concrete pore solution was studied. The point defect model was used to describe the response of the passive oxide film on the steel surface to the perturbation caused by the addition of the carboxylate compound. The electrochemical behavior of the steel specimens was evaluated through open circuit potential, electrochemical impedance spectroscopy and potentiodynamic analysis. The reduction in efficiency outside the optimal concentrations was discussed from an electrochemical point of view. We suggest that the performance of the inhibitor is highly dependent on the positively charged entities on the passive layer including anion vacancies and interstitial cations. To further investigate the physicochemical behavior of the organic molecules, density functional theory and adsorption isotherms were applied. The topography and morphology of the surface were analyzed through scanning electron microscopy. To confirm the inhibitive effect of EDTA, the elements and chemical bonds present on the surface were characterized via X-ray photoelectron spectroscopy. The surface analysis confirmed that the addition of EDTA formed a network of chemical bonds, which significantly hindered the corrosion phenomenon.Molybdenum dithiocarbamates (MoDTC) are widely used in automotive industries as lubricant additives to reduce friction and to enhance fuel economy. Sulfur-containing additives such as zinc dithiophosphates (ZnDTP) are proposed to play a key role in the improvement of friction reducing properties of MoDTC in formulated lubricants by facilitating the formation of MoS2 tribofilm at the rubbing contacts. This study focuses on the interactions between MoDTC and ZnDTP under conditions comparable with those prevailing in operating engines. The capacity of ZnDTP to sulfurize MoDTC in solution in a hydrocarbon base oil could be demonstrated. Sulfurized Mo complexes bearing one or two additional sulfur atoms (1S-MoDTC and 2S-MoDTC, respectively) which have replaced the genuine oxygen atom(s) from the MoDTC core were detected and quantified using a specifically developed HPLC-MS analytical method. A possible sulfurization mechanism relying on the higher affinity of phosphorus from ZnDTP for oxygen could be proposed. In parallel, the evolution and molecular transformation of the prepared 2S-MoDTC in hydrocarbon base oil under thermal and thermo-oxidative conditions were followed using HPLC-MS and compared with the evolution of their friction coefficients. 2S-MoDTC complexes were shown to exhibit a better retention of friction reducing capability under oxidative conditions than the "classical" MoDTC, although they did not seem to significantly reduce the friction coefficients of lubricants as compared to the "classical" MoDTC. Therefore, sulfurization of MoDTC by ZnDTP might contribute to delaying the progressive consumption of MoDTC and the loss of their friction-reducing efficiency in lubricants under thermo-oxidative conditions.Polystyrene (PS) electrospun nanofibers were prepared via electrospinning for the adsorption of clonazepam from aqueous solution. The adsorption conditions such as adsorption time, solution pH and the amount of adsorbent were optimized. The adsorption kinetics and thermodynamic properties of clonazepam on PS nanofibers were studied under optimized conditions. The pseudo-second-order kinetic model can fit well the adsorption process of clonazepam on polystyrene nanofibers, indicating that the diffusion process in the fiber is the rate-limiting step of the adsorption process. The adsorption equilibrium data are in accordance with the Freundlich isotherm model, and the maximum adsorption capacity is 3.2 mg g-1. Thermodynamic studies revealed that the adsorption process is endothermic and spontaneous in nature. It was suggested that PS electrospun nanofibers have good potential for the separation and purification of clonazepam from a water-soluble matrix as a novel effective adsorbent material.An in-flight coalescence reactive inkjet printer has been developed to facilitate the in-air collision of two reactive microdroplets. This way precise volumes of reactive inks can be mixed and subsequently deposited on the substrate to produce the desired product by polymer synthesis and patterning in a single step. In this work, we validate the printer capabilities by fabrication of a series of 3D structures using an aliphatic polyurea system (isophorone diisocyanate IPDI and poly(propylene glycol) bis(2-aminopropyl ether) PEA-400). The influence of temperature and ink ratio on the material properties has been investigated. An increase in both IPDI and temperature facilitates the production of materials with higher Young's Modulus E and higher ultimate strength U. The possibility of printing different materials i.e. ductile (U = 2 MPa, ε B = 450%), quasi-brittle (U = 14 MPa, ε B = 350%), and brittle (U = 10 MPa, ε B = 11%) by varying the printing process parameters using one set of inks has been presented. The anisotropy of the material properties arising from different printing directions is at the 20% level.In order to develop organic semiconductor materials with good performance, herein, a series of naphthalene derivatives were designed and synthesized by a "building-blocks approach" connected through α-bond, double bond, and triple bond, respectively. Thin-film transistors were fabricated in single-component and two-component modes based on these naphthalene derivatives by combining the F16CuPc as the n-type material. The ambipolar performance was investigated by adjusting the device preparation procedure with the hole and electron mobility of up to 10-2 cm2 V-1 s-1. 1,4-Diaminobutane Furthermore, the electrical performance was also improved to 0.73 cm2 V-1 s-1 using the two-component bilayer configuration.Hydrothermally synthesized poorly-crystalline metastable Zr-W binary hydroxide (W/Zr = 2), after calcination, was confirmed to be a strong solid acid catalyst to promote the alkylation of anisole with benzyl alcohol. The preparation conditions, structure of the as-prepared catalysts and the calcined hydroxides were investigated using XRD, nitrogen adsorption isotherms, TG-DTA, and XANES/EXAFS techniques. The crystalline phase was controlled by the hydrochloric acid concentration used for preparing a mother gel, and 5-9 M HCl was suitable for preparing the active phase. The tungsten species exists as a six-valent WO6 distorted octahedron connected with the ZrO7 unit via corner-sharing linkages. The incompleteness of the network structure is suggested to be responsible for the solid acidity.The gelatinization of potato starch and the effect of NaCl on starch gelatinization were monitored successfully in situ by 1H NMR spectroscopy. Variable temperature (VT) 1H NMR measurement, from 316 K to 340 K, was conducted on a suspension of potato starch and deuterium water as well as a mixture of potato starch, NaCl and deuterium water. The hydration level of starch was determined with the increase of temperature. In the presence of NaCl, the initial gelatinization temperature of potato starch was decreased from 331 to 328 K. Meanwhile, in situ 1H NMR spectroscopy as a function of time was also carried out to monitor the gelatinization with a time resolution of 90 s per spectrum. Furthermore, the effect of using different processing methods during gelatinization, including varying the temperature or time duration, was investigated in detail. It was confirmed that protons from different groups of starch showed different accessibility for water during hydration of starch granules. In comparison with temperature, gelatinization time as the major factor for reaching complete gelatinization was confirmed.
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