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The tailored telehealth party cigarette cessation treatment program for people with HIV: Study process for a randomized managed test.
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The RNA-binding protein Apobec1 complementation factor (A1CF) regulates posttranscriptional ApoB mRNA editing, but the range of RNA targets and the long-term effect of altered A1CF expression on liver function are unknown. check details Here we studied hepatocyte-specific A1cf-transgenic (A1cf+/Tg), A1cf+/Tg Apobec1-/-, and A1cf-/- mice fed chow or high-fat/high-fructose diets using RNA-Seq, RNA CLIP-Seq, and tissue microarrays from human hepatocellular cancer (HCC). A1cf+/Tg mice exhibited increased hepatic proliferation and steatosis, with increased lipogenic gene expression (Mogat1, Mogat2, Cidea, Cd36) associated with shifts in polysomal RNA distribution. Aged A1cf+/Tg mice developed spontaneous fibrosis, dysplasia, and HCC, and this development was accelerated on a high-fat/high-fructose diet and was independent of Apobec1. RNA-Seq revealed increased expression of mRNAs involved in oxidative stress (Gstm3, Gpx3, Cbr3), inflammatory response (Il19, Cxcl14, Tnfα, Ly6c), extracellular matrix organization (Mmp2, Col1a1, Col4a1), and proliferation (Kif20a, Mcm2, Mcm4, Mcm6), and a subset of mRNAs (including Sox4, Sox9, Cdh1) were identified in RNA CLIP-Seq. Increased A1CF expression in human HCC correlated with advanced fibrosis and with reduced survival in a subset with nonalcoholic fatty liver disease. In conclusion, we show that hepatic A1CF overexpression selectively alters polysomal distribution and mRNA expression, promoting lipogenic, proliferative, and inflammatory pathways leading to HCC.The family of monolayered Si2BN structures constitute a new class of 2D materials exhibiting metallic character with remarkable stability. Topologically, these structures are very similar to graphene, forming a slightly distorted honeycomb lattice generated by a union of two basic motifs with AA and AB stacking. In the present work we study in detail the structural and electronic properties of these structures in order to understand the factors which are responsible for their structural differences as well as those which are responsible for their metallic behavior and bonding. Their high temperature stability is demonstrated by the calculations of finite temperature phonon modes which show no negative contributions up to and beyond 1000 K. link= check details Presence of the negative thermal expansion coefficient, a common feature of one-atom thick 2D structures, is also seen. Comparison of the two motifs reveal the main structural differences to be the differences in their bond angles, which are affected by the third nearest neerturbed ph-Si, having very similar electronic properties as silicene, but with the advantage of having kinetic stability in planar form. As for the bonding, the Si-Si bonds are covalent, while theπback donation mechanism occurs for the B-N bonding, in accordance with the B-N bonding in h-BN.A series of green emitting Gd2O3Tb3+ (Tb 0%-10% mol) nanoparticles (NP) were synthesized using the hydrothermal method, then characterized and evaluated for latent fingerprint visualization. X-ray diffraction study (XRD) revealed a cubic structure of the nanoparticles and the total incorporation of the terbium in the Gd2O3 matrix. link2 Field Emission-Scanning Electron Microscopy (FESEM), Energy Dispersive x-ray Spectrometry (EDX) and Transmission Electron Microscopy (TEM) were used to study the morphology and the elementary composition of the NP. Photoluminescence (PL) studies showed strong green emission around 540 nm due to the transition 5D4 → 7F5. The luminescence color of the synthesized NP was characterized by the CIE 1931 chromaticity diagram. The potential use of the NP powders for the visualization of latent fingerprint under UV irradiation was assessed on various substrates. The latent fingerprint images revealed by the Gd2O3Tb3+ NP powders are clear enough to extract and analyze reliable fingerprint features. The fingerprint quality was evaluated using three fingerprint quality assessment metrics and by extracting and measuring the visibility of the minutiae. The experimental results show very good quality images of the latent fingerprint acquired using the Gd2O3Tb3+ NP and yield good minutiae extraction.The continuing miniaturization of optoelectronic devices, alongside the rise of electromagnetic metamaterials, poses an ongoing challenge to nanofabrication. With the increasing impracticality of quality control at a single-feature (-device) resolution, there is an increasing demand for array-based metrologies, where compliance to specifications can be monitored via signals arising from a multitude of features (devices). To this end, a square grid with quadratic sub-features is amongst the more common designs in nanotechnology (e.g. nanofishnets, nanoholes, nanopyramids, μLED arrays etc). The electrical resistivity of such a quadratic grid may be essential to its functionality; it can also be used to characterize the critical dimensions of the periodic features. While the problem of the effective electrical resistivity ρ eff of a thin sheet with resistivity ρ 1, hosting a doubly-periodic array of oriented square inclusions with resistivity ρ 2, has been treated before (Obnosov 1999 SIAM J. Appl. Math. 59 1267M4PP footprint.Color Vision Deficiency (CVD) is one of the most common types of vision deficiency. People with CVD have difficulty seeing color spectra depending on what types of retina photoreceptors are impaired. link2 In this paper, the Ishihara test with 38 plates was used to examine the Electroencephalogram (EEG) of ten subjects with CVD plus ten healthy individuals. The recording was performed according to the 10-20 international system. The C-based software was programmed so that subjects could select the number or path in each test plate in the software options while recording EEG. Frequency features in different frequency bands were extracted from the EEG signals of the two groups during the Ishihara test. Statistically significant differences (P less then 0.05) between features were assessed by independent samples t-test with False Discovery Rate (FDR) correction. Also, the K-nearest neighbor classifier (KNN) was used to classify the two groups. The results revealed that the most significant difference between the two groups in the Ishihara test images occurred for the electrodes located in the right temporoparietal areas (P4 and T6) of the brain in the Delta, Theta, Beta1, and Beta2 frequency bands. The KNN classifier, using the signals that reported the greatest statistical difference between the two groups, showed that the two groups were distinguishable with 85.2% accuracy. In this way, images from the Ishihara test that would provide the most accurate classification were identified. In conclusion, this research provided new insights into EEG signals of subjects with CVD and healthy subjects based on the Ishihara color vision test.Contacts between black phosphorene (BP) and metal electrodes are critical components of BP-based devices and can dramatically affect device performance. In this paper, we adopted first-principles calculations to explore binding energies, electronic structures, spatial potential distribution of monolayer BP-Ni interfaces in surface contact and edge contact types, and used density functional theoretical coupled with nonequilibrium Green's function method to investigate the electrical transport properties for transport systems of monolayer BP with Ni electrodes. check details Our calculated results indicate that contact type between monolayer BP and metal Ni electrodes may much affect the transport properties of monolayer BP-Ni devices. Interfacial interaction between Ni and monolayer BP in edge contact type is stronger than that in surface contact type. The potential distributions indicate that edge contact type is more beneficial for reducing contact resistance of monolayer BP-Ni contacts and conducive to improve the performance of BP-Ni electrode device.Macrophages are vital regulators of skeletal remodeling and osseous repair. Beta-tricalcium phosphate (β-TCP) is a synthetic ceramic biomaterial that has shown promise as bone substitute. However, whether and how β-TCP affects osteogenesis-related responses of macrophages has rarely been studied. The aims of this study were to explore (a) the effects of β-TCP on osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) co-cultured with macrophages and (b) on macrophage polarization as well as macrophage gene and protein expression profiles. BMSC osteogenic differentiation capacity in vitro was enhanced in β-TCP-induced co-cultured BMSCs compared to that in BMSC monocultures. We also found that macrophages induced with 25 mg ml-1 β-TCP extract had more significant immune responses and switched to the M2 phenotype. Expression levels of the Wnt signaling pathway modulators wingless-type MMTV integration site family, member 6 (WNT6) and Wnt inhibitory factor 1 (WIF1) were upregulated and downregulated, respectively, in macrophages treated with β-TCP extract. Our findings suggest that β-TCP enhances osteogenic differentiation of BMSCs by inducing macrophage polarization and by regulating the Wnt signaling pathway, thereby highlighting its therapeutic potential for bone healing through osteoimmunomodulatory properties.Tumor-specific targeted delivery is a major obstacle to clinical treatment of hepatocellular carcinoma (HCC). link3 Here we have developed a novel multi-functional nanostructure GAL-GNR-siGPC-3, which consists of Galactose (GAL) as the HCC-targeting moiety, golden nanorods (GNR) as a framework to destroy tumor cells under laser irradiation, and siRNA of Glypican-3 (siGPC-3) which induce specifically gene silence of GPC-3 in HCC. Glypican-3 (GPC-3) gene is highly associated with HCC and is a new potential target for HCC therapy. On the other hand, Gal can specifically bind to the asialoglycoprotein receptor which is highly expressed on membrane of hepatoma cells. GAL and siGPC-3 can induce targeted silencing of GPC-3 gene in hepatoma cells. In vivo and in vitro results showed that GAL-GNR-siGPC-3 could significantly induce downregulation of GPC-3 gene and inhibit the progression of HCC. More notably, GAL-GNR-siGPC-3 could induce both GPC-3 gene silencing and photothermal effects, and the synergistic treatment of tumors was more effective than individual treatments. In summary, GAL-GNR-siGPC-3 achieved a synergistic outcome to the treatment of cancer, which opens up a new approach for the development of clinical therapies for HCC.A composite of hydroxyapatite (HA) and polymers prepared from amino acids and glycolic acid (PAG) was synthesized using an in situ melting polycondensation method. The in vitro degradability and bioactivity of the composite were evaluated, as well as its in vitro and in vivo biocompatibility based on subcutaneous and osseous implantation of samples in New Zealand white rabbits for 8 weeks. The results showed that the PAG/HA composite had higher degradability than PAG and showed a typical apatite morphology after immersion in simulated body fluid for 5 days. Both the PAG/HA composite and PAG alone showed excellent in vitro biocompatibility. link3 In the rabbit model, PAG/HA composite could induce formation of new bone tissue after 4 weeks implantation, mainly owing to the excellent in vivo bioactivity of the implant. These results suggest that PAG/HA composites have the potential to guide bone regeneration and could be used as biodegradable biomaterials for bone repair.
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