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The effect of immunonutrition in patients undergoing hepatectomy remains unclear. This meta-analysis aimed to assess the impact of immunonutrition on postoperative clinical outcomes in patients undergoing hepatectomy.
A literature search of PubMed, Cochrane Library, Web of Science, and Embase databases was performed to identify all randomized controlled trials (RCTs) exploring the effect of perioperative immunonutrition in patients undergoing hepatectomy until the end of March 10, 2020. Quality assessment and data extraction of RCTs were conducted independently by 3 reviewers. Mean difference (MD) and odds ratio (OR) with 95% confidence interval (CI) were calculated using a fixed-effects or random-effects model. The meta-analysis was performed with RevMan 5.3 software.
Nine RCTs involving a total of 966 patients were finally included. This meta-analysis showed that immunonutrition significantly reduced the incidences of overall postoperative complications (OR = 0.57, 95% CI 0.34-0.95; p = 0.03), overall postoperative infectious complications (OR = 0.53, 95% CI 0.37-0.75; p = 0.0003), and incision infection (OR = 0.50, 95% CI 0.28-0.89; p = 0.02), and it shortened the length of hospital stay (MD = -3.80, 95% CI -6.59 to -1.02; p = 0.007). There were no significant differences in the incidences of pulmonary infection (OR = 0.60, 95% CI 0.32-1.12; p = 0.11), urinary tract infection (OR = 1.30, 95% CI 0.55-3.08; p = 0.55), liver failure (OR = 0.54, 95% CI 0.23-1.24; p = 0.15), and postoperative mortality (OR = 0.69, 95% CI 0.26-1.83; p = 0.46).
Given its positive impact on postoperative complications and the tendency to shorten the length of hospital stay, perioperative immunonutrition should be encouraged in patients undergoing hepatectomy.
Given its positive impact on postoperative complications and the tendency to shorten the length of hospital stay, perioperative immunonutrition should be encouraged in patients undergoing hepatectomy.Összefoglaló. Esetismertetések 66 éves nő vizsgálatai irreponibilis fájdalmas inguinalis terime miatt kezdődtek. Ultrahangvizsgálat során a panaszok hátterében femoralis sérvben kizárt gangraenás appendix vermiformis igazolódott. Inguinalis metszésből appendectomiát és hernioplasticát végeztünk. Posztoperatív szövődménye nem volt, szövettana appendicitist igazolt. Pár héttel később egy 76 éves, több társbetegséggel rendelkező férfi fájdalmas, sercegő gangraenás, jobb inguinalis terime miatt került átvételre. CT-vizsgálat femoralis sérvbe kizárt abscedáló appendix vermiformist ábrázolt. Inguinalis metszésből, illetve alsó median laparotomiából a féregnyúlványt a hasüregbe reponáltuk, majd appendectomia és inguinalis necrectomia történt. Posztoperatív adhéziós ileus és hasfali disruptio miatt egy alkalommal reoperáltuk, adhaesiolysist és hasfali resuturát végeztünk. Ezt követően lágyéki sebén negatív nyomásos sebkezelést alkalmaztunk, a beteget a 22. napon otthonába bocsájtottuk. Az appendix szövettana low gradanifestation, clinical findings and on the available equipment and the expertise of the surgeon.
The femoral hernia containing the appendix is called de Garengeot's hernia and is one of the rarest types of inguinofemoral hernias. The clinicopathology of this type of hernia can cover a wide range of symptoms. The definitive preoperative diagnosis is relatively difficult to find without a CT-scan. The surgical approach and treatment depends on the manifestation, clinical findings and on the available equipment and the expertise of the surgeon.Star fruit toxicity has been hugely described in patients with chronic kidney disease, either on conservative or renal replacement therapy. This is a case report of a man, without prior kidney or neurological dysfunction, who appeared to develop nephrotoxicity and neurotoxicity less than 12 hours after drinking concentrated star fruit juice (approximately 20 units of the fruit). He received timely renal replacement therapy and renal function fully recovered after discharge.The extensive use of antibiotics in hospitals and in the animal breeding industry has promoted antibiotic resistance in bacteria, which resulted in the emergence of a large number of antibiotic resistance genes in the intestinal tract of human and farmed animals. Genetic exchange of resistance genes between the two ecosystems is now well documented for pathogenic bacteria, but the repertoire of shared resistance genes in the commensal bacterial community and by which genetic modules they are disseminated are still unclear. By analyzing metagenomics data of human and pig intestinal samples both collected in Shenzhen, China, a set of 27 highly prevalent antibiotic resistance genes was found to be shared between human and pig intestinal microbiota. The mobile genetic context for 11 of these core antibiotic resistance genes could be identified by mining their carrying scaffolds constructed from the two datasets, leading to the detection of seven integrative and conjugative/mobilizable elements and two IS-related nce genes, the abundance is not explained by the same mobile genetic element in each host, suggesting that the human and pig microbial communities promoted a different set of mobile genetic carriers for the same antibiotic resistance genes. These results deepen our understanding of the dissemination of antibiotic resistance genes among and between human and pig gut microbiota.T-BSA binary complex was formed with non-covalent interactions between fluorometric 2-thioxanthone thioacetic acid and stabilizator bovine serum albumin by fluorescence emission spectroscopy as a sensible and practical method. T-BSA concentration at 1.77 × 10-4 M was obtained as the most suitable and reliable amount for the formation of T-BSA-Hg(II) triple complex. Trace amount of Hg(II) analyses were achieved by this new fluorometric triple complex system as the primary aim. The emission spectra from 350 nm to 650 nm were assayed on fluorometer for Hg(II) concentrations from 1.77 × 10-8 M to 3.53 × 10-4 M under an excitation wavelength of 337 nm. Hg(II) was found to increase the emission intensity of T-BSA by 50% even at 1.77 × 10-7 M Hg(II). So this new system has strong sensitivity to Hg(II) ion. T-BSA-Hg(II) triple complex formation and its fluorometric characterization have not been investigated in literature yet. This study is critically important to provide Hg(II) analyses in wastewater treatments and biological samples for further studies.For efficient solar energy harvesting, various engineering strategies to strengthen visible-light responsivity of ZnO photocatalyst is under intensive investigation. In this work, a new ternary C-ZnO/MoS2/mesoporous carbon nanocomposite was successfully prepared by a two-step solution-processed synthesis protocol. The ternary composite exhibits a well-interconnected 3D mesoporous microstructure assembled by carbon nanosheets, which is loaded with quasi 0D ZnO nanoparticles and 2D MoS2 nanosheets. The carbonaceous nanocomposites show enhanced visible-light-driven photocatalytic performance and high photo-corrosion resistance. The incorporation of carbon in the hybrid design has manifold benefits that drastically promotes the photoactivity and photostability. The significant enhancement in photodegradation activity of the hybrid catalysts can be ascribed to a few positive synergistic effects, such as increased surface area and active reaction sites, boosted surface charge utilization efficiency, and band-gap lowering. The high porosity of the distinct microstructure raises the dye adsorption within the material. Tailored interface/surface properties enable more effective mass transport and higher separation efficiency of photo-generated carriers. The modulated electronic structure leads to the narrowing of the ZnO optical bandgap. mTOR inhibitor Meanwhile, coupling with carbon prevents ZnO from photo-corrosion. Our approach highlights the roles of carbon as structure directing and stabilizing agents as well as heteroatom in defect engineering for wide band-gap oxide materials. The rational material design of multivariate mixed-dimensional architecture also provides guiding insight for the advancement of heterogeneous photocatalyst materials with superior performance and durability. The presented engineering strategy would be a promising method for the preparation of nanomaterials supported on 3D carbon network with high porosity and visible-light-driven photocatalytic performance.Elsberg syndrome (ES) refers to the combination of myelitis and lumbosacral radiculitis associated with infection caused by the virus of the Herpesviridae family. We present a case of a 52-year-old man with a 9 months diagnosis of Crohn's disease, in use of infliximab with good disease control, complaining of 2 months history of progressive urinary retention and loss of sensation of the genital and left lower limb regions associated with varicella zoster virus (VZV) infection and recent HIV diagnosis.Sediment in fluvial-deltaic plains with high-As groundwater is heterogenous but its characterization of As and Fe oxidation states lacks resolution, and is rarely attempted for aqueous and solid phases simultaneously. Here, we pair high-resolution (> 1 sample/meter) Fe extended fine-structure spectroscopy (EXAFS, n = 40) and As X-ray absorption near-edge spectroscopy (XANES, n = 49) with groundwater composition and metagenomics measurements for two sediment cores and their associated wells (n = 8) from the Yinchuan Plain in northwest China. At shallower depths, nitrate and Mn/Fe reducing sediment zones are fine textured, contain 9.6 ± 5.6 mg kg-1 of As(V) and 2.3 ± 2.7 mg kg-1 of As(III) with 9.1 ± 8.1 g kg-1 of Fe(III) (hydr)oxides, with bacterial genera capable of As and Fe reduction identified. In four deeper 10-m sections, sulfate-reducing sediments are coarser and contain 2.6 ± 1.3 mg kg-1 of As(V) and 1.1 ± 1.0 mg kg-1 of As(III) with 3.2 ± 2.6 g kg-1 of Fe(III) (hydr)oxides, even though groundwater As concentrations can exceed 200 μg/L, mostly as As(III). Super-enrichment of sediment As (42-133 mg kg-1, n = 7) at shallower depth is due to redox trapping during past groundwater discharge. Active As and Fe reduction is supported by the contrast between the As(III)-dominated groundwater and the As(V)-dominated sediment, and by the decreasing sediment As(V) and Fe(III) (hydr)oxides concentrations with depth.
To evaluate the utilisation of technologies and associated glycaemia among adults with type 1 diabetes.
De-identified data from adults with type 1 diabetes (≥18years old) in the Australian National Diabetes Audit (ANDA)-2019 were analysed. Proportions using insulin pumps or injections with continuous glucose monitoring (CGM) or capillary-glucose testing were compared. Technology use among adults was compared to young people (<21years old) with subsidised CGM. Glycaemia and complication-burden were assessed across management strategies.
1,693 adults were analysed. Mean(±SD) age, diabetes duration, and HbA1c were 43.3±17.0years, 20.3±14.3years and 8.4%±1.7 [68±19mmol/mol], respectively. Among adults, 40% used at least one device, 27% used insulin pumps, and 23% used CGM. CGM was used by 62% of young people with subsidised access. Mean HbA1c was consistently lower among adults using CGM, insulin pumps, or combined insulin pump and CGM compared to standard care (8.3%±1.6 [67±18mmol/mol], 8.2%±1.4 [66±15mmol/mol], and 7.
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