Notes

Persistent Nephrolithiasis On account of Parathyroid Adenoma.
The combination of morphometrics, phylogenetic comparative methods, and open data sets has renewed interest in relating morphology to adaptation and ecological opportunities. Focusing on the Caviomorpha, a well-studied mammalian group, we evaluated patterns in research and data sharing in studies relating form and function. Caviomorpha encompasses a radiation of rodents that is diverse both taxonomically and ecologically. We reviewed 41 publications investigating ecomorphology in this group. We recorded the type of data used in each study and whether these data were made available, and we re-digitized all provided data. We tracked two major lines of information collections material examined and trait data for morphological and ecological traits. Collectively, the studies considered 63% of extant caviomorph species; all extant families and genera were represented. We found that species-level trait data rarely were provided. Specimen-level data were even less common. Morphological and ecological data were too htiendo la futura integración de datos derivados de ejemplares con datos sobre rasgos ecomorfológicos a nivel de especie.Foraging by animals is hypothesized to be state-dependent, that is, varying with physiological condition of individuals. State often is defined by energy reserves, but state also can reflect differences in nutritional requirements (e.g., for reproduction, lactation, growth, etc.). Testing hypotheses about state-dependent foraging in ungulates is difficult because fine-scale data needed to evaluate these hypotheses generally are lacking. To evaluate whether foraging by caribou (Rangifer tarandus) was state-dependent, we compared bite and intake rates, travel rates, dietary quality, forage selection, daily foraging time, and foraging strategies of caribou with three levels of nutritional requirements (lactating adults, nonlactating adults, subadults 1-2 years old). Only daily foraging times and daily nutrient intakes differed among nutritional classes of caribou. Lactating caribou foraged longer per day than nonlactating caribou-a difference that was greatest at the highest rates of intake, but which persisted even when intake was below requirements. Further, at sites where caribou achieved high rates of intake, caribou in each nutritional class continued foraging even after satisfying daily nutritional requirements, which was consistent with a foraging strategy to maximize energy intake. Foraging time by caribou was partially state-dependent, highlighting the importance of accounting for physiological state in studies of animal behavior. Fine-scale foraging behaviors may influence larger-scale behavioral strategies, with potential implications for conservation and management.Knowledge as to the taxonomic status of enigmatic bat species often is hindered by limited availability of specimens. This is particularly true for aerial-hawking bats that are difficult to catch. One such species, "Hypsugo" joffrei, was originally described in Nyctalus due to its long and slender wings, but subsequently transferred to Pipistrellus, and most recently to Hypsugo, on the basis of morphology. Analysis of newly available material, which more than doubles the known specimens of this taxon, demonstrates that it is morphologically and genetically distinct from all other bat genera. We accordingly describe it as belonging to a new, monotypic genus. We provide a detailed description of its external and craniodental traits, measurements, and assessment of genetic relationships, including barcode sequences to facilitate its rapid identification in future. SAHA mouse The new genus belongs to a group that includes the recently described Cassistrellus, as well as Tylonycteris, and its closest relative, Philetor. We also describe the echolocation calls emitted by members of the taxon in different situations, which may facilitate finding them in previously unsampled locations. Based on the new data, the species occurs from Nepal to North Vietnam and China, which suggests that it could be more widespread than previously thought.The Japan Aerospace Exploration Agency's (JAXA) Kaguya spacecraft carried a suite of instruments to map the Moon and its environment globally. During its extended mission, the average altitude was 50 km or lower, and Kaguya science products using these data hence have an increased spatial resolution. However, the geodetic position quality of these products is much worse than that of those acquired during the primary mission (at an altitude of 100 km) because of reduced radiometric tracking and frequent thrusting to maintain spacecraft attitude after the loss of momentum wheels. We have analyzed the Kaguya tracking data using gravity models based on the Gravity Recovery and Interior Laboratory (GRAIL) mission, and by making use of a new data type based on laser altimeter data collected by Kaguya we adjust the spacecraft orbit such that the altimetry tracks fit a precise topographic basemap based on the Lunar Reconnaissance Orbiter's (LRO) Lunar Orbiter Laser Altimeter (LOLA) data. This results in geodetically accurate orbits tied to the precise LOLA/LRO frame. Whereas previously archived orbits show errors at the level of several a level of several tens of meters. When altimetry data are not available, the combination of GRAIL gravity and radio tracking results in an orbit precision of around several hundreds of meters for the low-altitude phase of the extended mission. Our greatly improved orbits result in better geolocation of the Kaguya extended mission data set.Surface ice at the poles of Mercury appears as several-m-thick deposits that are composed of nearly pure water. We provide new age estimates of Mercury's polar deposits from combined analyses of Poisson statistics and direct observations of crater densities within permanently shadowed, radar-bright regions imaged by the MESSENGER spacecraft. These age estimates suggest that ice was delivered to Mercury within the last ~150 Myr. A single, recent impactor is one possible delivery mechanism that is consistent with our new age constraints, as well as the observed distinct reflectance boundaries of the polar deposits and the relative purity of the ice, as suggested by the Earth-based radar observations. In contrast to ice on Mercury, observations of the lunar poles are suggestive of a highly patchy distribution of surface frost. The patchiness of lunar polar deposits is consistent with long exposure times to the space weathering environment. Given enough time, the polar deposits on Mercury may age into a more heterogeneous spatial distribution, similar to that on the Moon.Respondent-driven sampling is an approach for estimating features of populations that are difficult to access using standard survey tools, e.g., the fraction of injection drug users who are HIV positive. Baraff et al. (2016) introduced an approach to estimating uncertainty in population proportion estimates from respondent-driven sampling using the tree bootstrap method. In this paper we establish the consistency of this tree bootstrap approach in the case of [Formula see text]-trees.We consider scenarios in which the likelihood function for a semiparametric regression model factors into separate components, with an efficient estimator of the regression parameter available for each component. An optimal weighted combination of the component estimators, named an ensemble estimator, may be employed as an overall estimate of the regression parameter, and may be fully efficient under uncorrelatedness conditions. This approach is useful when the full likelihood function may be difficult to maximize, but the components are easy to maximize. It covers settings where the nuisance parameter may be estimated at different rates in the component likelihoods. As a motivating example we consider proportional hazards regression with prospective doubly censored data, in which the likelihood factors into a current status data likelihood and a left-truncated right-censored data likelihood. Variable selection is important in such regression modelling, but the applicability of existing techniques is unclear in the ensemble approach. We propose ensemble variable selection using the least squares approximation technique on the unpenalized ensemble estimator, followed by ensemble re-estimation under the selected model. The resulting estimator has the oracle property such that the set of nonzero parameters is successfully recovered and the semiparametric efficiency bound is achieved for this parameter set. Simulations show that the proposed method performs well relative to alternative approaches. Analysis of an AIDS cohort study illustrates the practical utility of the method.The fused lasso, also known as total-variation denoising, is a locally adaptive function estimator over a regular grid of design points. In this article, we extend the fused lasso to settings in which the points do not occur on a regular grid, leading to a method for nonparametric regression. This approach, which we call the [Formula see text]-nearest-neighbours fused lasso, involves computing the [Formula see text]-nearest-neighbours graph of the design points and then performing the fused lasso over this graph. We show that this procedure has a number of theoretical advantages over competing methods specifically, it inherits local adaptivity from its connection to the fused lasso, and it inherits manifold adaptivity from its connection to the [Formula see text]-nearest-neighbours approach. In a simulation study and an application to flu data, we show that excellent results are obtained. For completeness, we also study an estimator that makes use of an [Formula see text]-graph rather than a [Formula see text]-nearest-neighbours graph and contrast it with the [Formula see text]-nearest-neighbours fused lasso.Legal and illegal wildlife trade is a multibillion dollar industry that is driving several species toward extinction. Even though wildlife trade permeates the Tree of Life, most analyses to date focused on the trade of a small selection of charismatic vertebrate species. Given that vertebrate taxa represent only 3% of described species, this is a significant bias that prevents the development of comprehensive conservation strategies. In this short contribution, we discuss the significance of global wildlife trade considering the full diversity of organisms for which data are available in the IUCN database. We emphasize the importance of being fast and effective in filling the knowledge gaps about non-vertebrate life forms, in order to achieve an in-depth understanding of global trading patterns across the full canopy of the Tree of Life, and not just its most appealing twig.Leber hereditary optic neuropathy (LHON) is a genetic condition that typically presents with unilateral, painless, sub-acute central vision loss followed by contralateral vision loss after a few weeks to months. It is a rare disease that typically affects young adults - men more than women - and is a relatively common cause of blindness. It is due to a mutation in mitochondrial DNA (mtDNA). The majority (more than 95%) of patients have one of three mtDNA point mutations m.14484T→C, m.3460G→A, or m.11778G→A. These mutations lead to disruption of the mitochondrial respiratory chain activating pro-apoptotic pathways. For reasons unknown, this insult tends to affect the retinal ganglion cells more than any other cell in the body, leading to the disease state. Due to its low prevalence in the United States (150,000), this diagnosis is often overlooked, misdiagnosed, and mismanaged, which may exacerbate symptoms. It is essential then for physicians to recognize the presentation of and understand the diagnostic work-up for LHON.
Here's my website: https://www.selleckchem.com/products/Vorinostat-saha.html