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Any Microfluidics-Based Scalable Method of Produce Extracellular Vesicles using Superior Healing MicroRNA Filling regarding Intranasal Delivery in order to Computer mouse Glioblastomas.
Purpose To investigate the expression of secreted frizzle-related protein 1 (SFRP1) and macrophage migration inhibitory factor (MIF) in elderly patients with severe periodontitis and its correlation with cognitive function. Methods Thirty-two elderly patients with periodontitis in Qingdao Stomatological Hospital from February 2018 to February 2019 were enrolled, and divided into two groups according to the severity mild group and severe group. All selected subjects received periodontal examination and Montreal cognitive assessment (MoCA).The expression of SFRP1 and MIF in serum was also determined. Then the correlations among SFRP1 and MIF periodontal index and cognitive function was analyzed. The data were processed by SPSS 20.0 software package. Results The probing depth (PD), clinical attachment level (CAL), sulcus bleeding index (SBI) and gingival crevicular fluid (GCF) showed significant difference between the two groups (P less then 0.05). The serum levels of SFRP1 and MIF in the severe group were significantly higher than those in the mild group (P less then 0.05). Serum SFRP1 level was positively correlated with MIF (P less then 0.05). Serum SFRP1 and MIF levels were positively correlated with periodontal index (P less then 0.05). The MoCA score of the severe group was significantly lower than that of the mild group (P less then 0.05). Serum SFRP1 and MIF levels were negatively correlated with MoCA score (P less then 0.05). Conclusions SFRP1 and MIF are highly expressed in serum and gingival tissues of elderly patients with severe periodontitis, and are closely related to the degree of periodontal damage. Meanwhile, patients with periodontitis may have some degree of cognitive dysfunction, and SFRP1 and MIF may affect the periodontal tissue structure through Wnt/β-catenin signal pathway and participate in the occurrence and development of cognitive dysfunction.Purpose To investigate the correlation between salivary stress markers chromogranin A (CgA), cortisol, α-amylase, β-endorphin and clinical parameters of periodontitis, including sulcus bleeding index (SBI), periodontal probing depth (PD) and attachment loss (AL). Methods A total of 105 patients with chronic periodontitis (periodontitis group) and 105 healthy individuals (control group) visiting our hospital from December 2017 to December 2018 were selected. Indicators including CgA, cortisol, α-amylase, β-endorphin levels, SBI, PD, and AL were detected in both groups, and the correlation among them was determined by Pearson's analysis, multivariate logistic regression was used to analyze the risk factors associated with periodontitis using SPSS 22.0 software package. Results The levels of CgA, cortisol, α-amylase and β-endorphin in the periodontitis group were significantly higher than those in the control group (P less then 0.05). SBI, PD and AL in the periodontitis group were significantly higher than those in the control group (P less then 0.05). The levels of CgA, cortisol, α-amylase and β-endorphin in saliva were positively correlated with SBI, PD, and AL (P less then 0.05). CgA, cortisol, α-amylase, and β-endorphin were independent risk factors for periodontitis (P less then 0.05). Conclusions Salivary stress markers CgA, cortisol, α-amylase, and β-endorphin are significantly associated with clinical parameters of periodontitis, suggesting that they can reflect the progression of periodontitis, thus providing an effective reference for diagnosis and efficacy monitoring of periodontitis.Purpose To observe the effect of dynamic nutrition support on postoperative energy metabolism, immune function and stress response in patients with oral and maxillofacial tumors. Methods Fifty-six patients with oral and maxillofacial tumor surgery were randomly divided into experimental group and control group (28 in each group). Patients in the experimental group received dynamic enteral and parenteral nutrition support according to the stress period after surgery, ω-3 fish oil fat milk injection and glutamine were added in the nutrition support program. Patients in the control group were given routine postoperative enteral and parenteral camp support. Energy metabolism, immune function and stress indexes were detected 1 day before surgery, 2 days after surgery and 7 days after surgery, respectively. SPSS 19.0 software package was used to analyze the data. Results Energy metabolism indexes in the experimental group were higher than the control group on day 2 after PA surgery and day 7 after ALB and PA surgery, while energy metabolism indexes in the experimental group were lower than the control group on day 2 and day 7 after FPG and TG surgery with significant difference(P less then 0.05). The levels of IgA, IgG, IgM, CD3+, CD4+ and CD4+/CD8+ in the experimental group were higher than those in the control group 7 days after surgery, with significant differences (P less then 0.05). The levels of CRP, TNF- and IL-6 in the experimental group were lower than those in the control group 7 days after surgery, and the difference was significant(P less then 0.05). There was no significant difference in postoperative complications between the two groups. Conclusions Dynamic nutrition support can improve postoperative energy metabolism of patients with oral and maxillofacial tumors, improve immune function, and alleviate stress response.Purpose To investigate the category and prevalence rate of denture-related oral mucosal lesions (DML) in 185 patients with removable denture and analyze the influencing factors. Methods A total of 185 patients with removable denture who visited the department of stomatology of our hospital from October 2015 to June 2018 were investigated by questionnaire. DML types and locations were recorded in detail, and patients were followed up after treatment. Based on the data of this study, the differences of DML reports in other regions of China were analyzed by comparing the results searched from databases. SPSS 17.0 software package was used for statistical analysis. Desferrioxamine B chemical structure Results In this study, the DML prevalence rate was 42.7%, significantly higher in male patients than in female patients (54.17% vs 35.40%, P less then 0.05). link2 DML was more common in complete denture wearers than that in partial denture wearers (66.67% vs 31.20%, P less then 0.05). The categories of DML were as followed (prevalence rate from high to low) denture stomatitis (54.43%), traumatic ulcer (34.18%), inflammatory hyperplasia (6.33%), and angular cheilitis (5.06%). Conclusions DML is affected by multiple factors. Among them, denture related factors include denture type, denture wearing time, denture lasting time and cleaning method. DML is more influenced by the type of denture than the wearing time. Gender, ethnicity and systemic diseases may affect the prevalence of DML, but further studies are needed. The results of domestic studies in various regions cannot objectively reflect the current prevalence rate of DML, thus a multi-center epidemiological investigation is needed.Purpose To investigate the prevalence of dental caries in young children aging 1 to 3 years in Chengdu city and the relationship with family oral hygiene habits. Methods One thousand children aging 1 to 3 years in 5 kindergartens in Chengdu city were selected as the study subjects, and examined for oral hygiene. They were divided into case group and control group according to the presence of dental caries. Questionnaires were sent out to two groups of children to find out their oral hygiene habits, and the results were compared and analyzed with SPSS 20.0 software package. Results Three hundred and thirty-one children suffered from dental caries, and the incidence of dental caries was 33.10%. There was no significant differences in sex, low birth weight, gestational age, medical history, parents' highest educational background and main caregivers between the case group and the control group (P>0.05); there were significant differences in age distribution, feeding methods and annual family income between two groups (P less then 0.05). In addition to the frequency of flossing and brushing, there were significant differences in other family oral hygiene behaviors between two groups (regular dental examination, frequency of sweets eaten by children, frequency of sweets eaten before sleep and frequency of sweets eaten by parents) (P less then 0.05). Multivariate analysis showed that age, annual family income, sleeping with bottles, regular examination of children's teeth, frequency of children eating sweets and frequency of children eating before sleep were all influencial factors of caries in young children (P less then 0.05). Conclusions Prevalence of dental caries in young children in Chengdu city is high, and there is significant correlation between dental caries in young children and family oral health behavior, which is one of the influencing factors for dental caries in young children.Purpose To detect the expression and significance of Ki-67, PI3K and Beclin1 in oral squamous cell carcinoma (OSCC). Methods Thirty patients with OSCC admitted to Nanjing Stomatology Hospital from January 2017 to December 2018 were selected. All specimens were harvested and treated with immunohistochemical staining. The expressions of Ki-67, PI3K and Beclin 1 were detected. Pearson's correlation was used to analyze the correlation among TMSG-1, Ki-67 and Pgp1.The data were analyzed with SPSS 20.0 software package. Results The positive rates of Ki-67 and PI3K in OSCC tissues were significantly higher than those in adjacent tissues, and the positive rates of Beclin1 were significantly lower than those in adjacent tissues (P0.05). Ki-67 was positively correlated with PI3K (r=0.391, P=0.032), Ki-67 was negatively correlated with Beclin1 (r=-0.525, P=0.02), and Beclin1 was negatively correlated with PI3K(r=-0.367, P=0.045). Conclusions Ki-67, PI3K and Beclin1 are correlated with lymph node metastasis and pathological staging. They may be involved in the occurrence and development of OSCC.Purpose To compare the differences of influence of mothers' different socio-demographic background, their oral health status and feeding behavior on their one-month-old infants' risk of dental caries between Shanghai and Kunming, and to explore the factors affecting infants' risk of dental caries in different regions. link3 Methods One-month-old infants and their mothers from Huangpu district of Shanghai and Xishan district of Kunming were recruited in the study. Oral plaque samples of mothers and their infants were collected to assess their risk of dental caries. Statistical analysis was performed using SPSS 22.0 software package, and multivariate logistic regression analysis was used to screen the factors affecting the risk of infantile rickets in Shanghai and Kunming. Resulits A total of 165 mother-child pairs in Shanghai and 161 mother-child pairs in Kunming participated in the survey, and the proportion of infants who were at high risk of caries was 10.3% and 6.2%, respectively. The result of multivariate logistic analysis indicated that the infants whose mother smoked before pregnancy (OR=6.9, P=0.030) and attained lower education level (OR=6.1, P=0.035) had higher risk of caries in Shanghai; while in Kunming, the infants whose mother had higher DMFS values were at higher risk of caries (OR=1.1, P=0.031). Conclusions Factors affecting one-month-old infants' risk of caries in Shanghai and Kunming were pre-pregnancy maternal cigarette smoking, mother's lower education level and mother's dental caries status, respectively.
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