Notes

[The arranging regarding specialists and the position involving technological societies. How much perhaps there is associated with research?
This study aimed to determine whether perceived environmental pollution is associated with subjective cognitive decline (SCD) or SCD-related functional difficulties. We conducted a cross-sectional study using data from a nationwide sample of 191,054 individuals aged ≥19 years from the 2018 Korea Community Health Survey. Perceived air, water, soil, noise, and green space pollution was assessed. To investigate the dose-response effect of the amount of perceived environmental pollution, we determined whether an increasing number of types of perceived environmental pollution also increased the odds of having SCD or SCD-related functional difficulties. Among the 191,054 individuals, the prevalence of SCD and SCD-related functional difficulties was 17.7% (N = 33,853) and 2.2% (N = 4139), respectively. Perception of air, soil, or noise pollution was significantly associated with SCD. However, the perception of any type of environmental pollution was not significantly associated with SCD-related functional difficulties. With regard to a dose-response effect, individuals perceiving a greater number of types of environmental pollution had significantly higher odds of SCD or SCD-related functional difficulties. This association was notably more evident in the younger age group.A nitrifying bacterium Acinetobacter sp. AL-6 showed a high efficiency of 99.05% for Mn(II) removal within 144 h when the Mn(II) concentration was 200 mg L-1; meanwhile, 64.23% of NH4+-N was removed. With the Mn(II) concentration increased from 25 to 300 mg L-1, bacterial growth and Mn(II) removal were stimulated. However, due to the electron acceptor competition between Mn(II) oxidation and nitrification reactions, the increase in NH4+-N concentration would inhibit Mn(II) removal. By measuring Mn metabolic form and locating oxidative active factors, it was proved that extracellular oxidation effect played a dominant role in the removal process of Mn(II). The self-regulation of pH during strain metabolism further promoted the occurrence of biological Mn oxidation. Characterization results showed that the Mn oxidation products were tightly attached to the surface of the bacteria in the form of flakes. The product crystal composition (mainly MnO2 and Mn2O3), Mn-O functional group, and element level fluctuations confirmed the biological oxidation information. The changes of -OH, N-H, and -CH2 groups and the appearance of new functional groups (such as C-H and C-O) provided more possibilities for Mn ion adsorption and bonding.Associations between ambient particulate matter exposure and platelet counts are inconsistent in previous studies, and study on the effect of long-term exposure especially in Asian populations is limited. We explored the associations between long-term PM2.5 (particulate matter less then 2.5 μm) exposure and platelet counts using a prospective cohort study in Northeast China. We used a logistic regression model to analyze the effects of different PM2.5 increments and platelet count elevation. Mixed linear models were used to analyze the association between PM2.5 concentration and platelet counts. LYN-1604 Interaction and sub-group analyses were also conducted. Results showed that every 1 μg/m3 increment of PM2.5 exposure was associated with 0.29% (95%CI 0.25-0.32%) increase in platelet counts and 10% (95%CI 8-12%) higher risk of platelet elevation. Effects of long-term PM2.5 exposure on platelet elevation were stronger in male participants, of Han ethnicity, and without diabetes. Long-term PM2.5 exposure would increase platelet counts in adults in Northeast area of China, which might add more evidence to the potential biological mechanisms responsible for the effect of air pollution exposure on cardiovascular disease.
Obesity and its associated medical problems increase risk of kidney function decline while prior studies suggest that bariatric surgery may improve kidney outcomes. However, little is known about the comparative effectiveness of different types of bariatric surgery on kidney function. In this study, we compare the effects of laparoscopic one anastomosis gastric bypass (LOAGB) and laparoscopic Roux-en-Y gastric bypass (LRYGB) on kidney function one year after surgery.

The patients' demographic, medical, and surgical data were prospectively collected and retrospectively reviewed. Type 2 diabetes mellitus, hypertension, and dyslipidemia, body mass index (BMI), and kidney function tests were obtained before and one year after surgery. Kidney function was evaluated by estimated glomerular filtration rate (eGFR) and spot urine albumin to creatinine ratio (ACR). Changes in eGFR and ACR were compared between LRYGB vs. LOAGB after adjustment for confounders (age, sex, remission of associated medical problems, preoperative BMI, and percentage of excess BMI loss) using ANCOVA model.

Both surgical techniques significantly decreased the post-surgery presence of diabetes, hypertension, and dyslipidemia (p < 0.001 for all paired comparisons). The eGFR level significantly increased and the ACR level significantly decreased in both groups (p < 0.001 for all paired comparisons before and after adjustment). However, eGFR and ACR mean differences between LRYGB and LOAGB were not significantly different after adjustment for confounding variables (p = 0.9 and 0.4, respectively).

Both LOAGB and LRYGB improved 1-year eGFR and ACR equally independently from weight loss and other confounders.
Both LOAGB and LRYGB improved 1-year eGFR and ACR equally independently from weight loss and other confounders.
To explore how the assisted reproductive technology (ART) laboratories can be optimized and standardized to enhance embryo culture and selection, to bridge the gap between standard practice and the new concept of shortening time to healthy singleton birth.

A Delphi consensus was conducted (January to July 2018) to assess how the ART laboratory could be optimized, in conjunction with existing guidelines, to reduce the time to a healthy singleton birth. Eight experts plus the coordinator discussed and refined statements proposed by the coordinator. The statements were distributed via an online survey to 29 participants (including the eight experts from step 1), who voted on their agreement/disagreement with each statement. Consensus was reached if ≥ 66% of participants agreed/disagreed with a statement. If consensus was not achieved for any statement, that statement was revised and the process repeated until consensus was achieved. Details of statements achieving consensus were communicated to the participants.

Consensus was achieved for all 13 statements, which underlined the need for professional guidelines and standardization of lab processes to increase laboratory competency and quality. The most important points identified were the improvement of embryo culture and embryo assessment to shorten time to live birth through the availability of more high-quality embryos, priority selection of the most viable embryos and improved cryosurvival.

The efficiency of the ART laboratory can be improved through professional guidelines on standardized practices and optimized embryo culture environment, assessment, selection and cryopreservation methodologies, thereby reducing the time to a healthy singleton delivery.
The efficiency of the ART laboratory can be improved through professional guidelines on standardized practices and optimized embryo culture environment, assessment, selection and cryopreservation methodologies, thereby reducing the time to a healthy singleton delivery.Coronavirus 2019 (COVID-19) is a new infectious disease that continues to spread globally. There is growing concern about donor-induced transmission of Coronavirus 2 (SARS -CoV-2). For liver transplantation, the COVID-19 PCR test is routine, in addition to epidemiological history and clinical and radiological examination 24-48 h before surgery. One of the liver transplant candidates was found to be infected with COVID-19, as well as the planned donor candidate. Since COVID-19 will be a high-risk operation for both the recipient and the donor, the operation was postponed by giving medical treatment. After the treatment and quarantine process was over, the patient and the donor then had a negative COVID-19 PCR test and the patient received a living donor liver transplant. We present a case of donor and recipient who initially both tested positive for COVID-19. This liver transplantation scenario has not previously been reported in the literature.Phenotype-specific omic expression patterns in people with frailty could provide invaluable insight into the underlying multi-systemic pathological processes and targets for intervention. Classical approaches to frailty have not considered the potential for different frailty phenotypes. We characterized associations between frailty (with/without disability) and sets of omic factors (genomic, proteomic, and metabolomic) plus markers measured in routine geriatric care. This study was a prevalent case control using stored biospecimens (urine, whole blood, cells, plasma, and serum) from 1522 individuals (identified as robust (R), pre-frail (P), or frail (F)] from the Toledo Study of Healthy Aging (R=178/P=184/F=109), 3 City Bordeaux (111/269/100), Aging Multidisciplinary Investigation (157/79/54) and InCHIANTI (106/98/77) cohorts. The analysis included over 35,000 omic and routine laboratory variables from robust and frail or pre-frail (with/without disability) individuals using a machine learning framework. We identified three protective biomarkers, vitamin D3 (OR 0.81 [95% CI 0.68-0.98]), lutein zeaxanthin (OR 0.82 [95% CI 0.70-0.97]), and miRNA125b-5p (OR 0.73, [95% CI 0.56-0.97]) and one risk biomarker, cardiac troponin T (OR 1.25 [95% CI 1.23-1.27]). Excluding individuals with a disability, one protective biomarker was identified, miR125b-5p (OR 0.85, [95% CI 0.81-0.88]). Three risks of frailty biomarkers were detected pro-BNP (OR 1.47 [95% CI 1.27-1.7]), cardiac troponin T (OR 1.29 [95% CI 1.21-1.38]), and sRAGE (OR 1.26 [95% CI 1.01-1.57]). Three key frailty biomarkers demonstrated a statistical association with frailty (oxidative stress, vitamin D, and cardiovascular system) with relationship patterns differing depending on the presence or absence of a disability.
International guidelines emphasise the importance of securing ruptured cerebral aneurysms within 48-72h of ictus. We assessed the timing of treatment of patients with aneurysmal subarachnoid haemorrhage (aSAH) referred to a national neurosurgical centre.

Analysis of a prospective database of patients with aSAH admitted between 1st of February 2016 and 29th of February 2020 was performed. The timing to treatment was expressed in days and analysed in three ways ictus to treatment, ictus to referral and referral to treatment. ORs with 95% CI were calculated for aneurysm treatment within 24, 48 and 72h for goodgrade (WFSN 1-3) and poorgrade (WFNS 4-5) cohorts separately.

Of a total of 538 patients with aSAH, the aneurysm was secured in 312 (58%) within 24h and in 398 (74%) within 48h of ictus. Securing the aneurysm within 48h of ictus was achieved in 89% (395/444) of patients who were referred within 24h of ictus, but in only 3.2% (3/94) who were referred > 24h after ictus. Poorgrade patients (WFNS 4-5) were more likely than goodgrade patients (WFNS 1-3) to be referred to neurosurgery within 48h of ictus (OR 22.
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