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Together, our results suggest that episodic memory disturbances may be an under-appreciated clinical feature of LPA.The desire to design and build skyrmion-based devices has led to the need to characterize magnetic textures in thin films of functional materials. This can usually be achieved through the Lorentz transmission electron microscopy (LTEM) and the Lorentz scanning transmission electron microscopy (LSTEM) in thin film cross-section and single crystal specimens. However, direct imaging of the magnetic texture in plan-view samples of thin ( less then 50 nm) films has proved to be challenging due to the complex "background" contrast associated with the microstructure and defects, as well as contributions from bending of the specimens. Using a mechanically polished 35 nm plan-view FeGe thin film, we have explored three methods to extract magnetic contrast from the complex background contrast observed; (1) background subtraction in defocused LTEM images, (2) frequency filtered CoM-DPC reconstructed from LSTEM datasets and 3) registration of 4D-STEM datasets acquired at different tilt angles. Using these methods, we have successfully implemented real space imaging of both the helical phase and skyrmion phase. The ability to understand nanoscale magnetic behavior from plan-view thin films is a fundamental step towards development of highly integrated spin electronics.
To discover if nursing students have improved their level of pain knowledge and their attitudes towards pain management over the last 20years.

Systematic review utilising the Kable, Pich, and Maslin-Prothero 12 step approach to document a search strategy.

A search was conducted from 2000 to 2020 using CINAHL, PubMed, Embase and ProQuest.

Studies exploring the level of pain management knowledge and attitudes of nursing students were included. The Critical Review Form - Quantitative Studies provided the appraisal framework (Law et al., 1998). Bemcentinib supplier A narrative synthesis of eligible studies was undertaken.

Six studies with a total of 1454 participants were included. The studies demonstrated that nursing students have not improved their level of pain knowledge and attitudes towards pain management in the last 20years. Whilst many nursing students thought they possessed adequate pain knowledge, the studies all demonstrated that their pain knowledge is lacking and that they do not have appropriate attitudes towards pain. Students did not recognise the patient who was not grimacing as being in pain despite the patient report of pain.

These findings support the notion that nursing education does not include sufficient focus on pain identification and management. Alignment of nursing pain education with the curriculum developed in 1993 by the International Association for the Study of Pain is needed to ensure nurses have appropriate knowledge so that patients can receive effective pain management.
These findings support the notion that nursing education does not include sufficient focus on pain identification and management. Alignment of nursing pain education with the curriculum developed in 1993 by the International Association for the Study of Pain is needed to ensure nurses have appropriate knowledge so that patients can receive effective pain management.Doxorubicin (DOX) is one of the most widely used chemotherapeutic agents. However, it causes pulmonary toxicity which decreases its clinical use in human cancer therapy. The present study was undertaken to obtain an insight into the potential protective effect of hesperetin (HES) against doxorubicin-induced pulmonary toxicity in rats. The animals were divided into 4 groups with 7 rats per group. The experimental treatments were as follows Control, DOX, DOX + HES, and HES groups. DOX was administered at the dosage of 15 mg/kg i.p for a single dose. HES was administered at the dosage of 50 mg/kg by oral gavage every other day. After 28 days, biochemical parameters, oxidative stress status, histopathological changes, apoptosis-related genes and apoptotic index (AI) were examined of lung tissue. Histopathological changes, Poly [ADP-ribose] polymerase 1 (PARP-1), Caspase-3 (Casp3), Cytochrome c (Cytc), apoptosis-related genes, and AI significantly increased in the DOX group relative to the control group. Malondialdehyde (MDA) significantly increased, while superoxide dismutase (SOD) and glutathione peroxidase (GPx) decreased in the DOX group relative to the control group. However, histopathological findings, MDA, AI, and PAPR1, Casp3 protein expression, mRNA expression of Cytc significantly decreased, while SOD, GPx increased in the DOX + HES group relative to the DOX group. These results attested HES might be a potential agent for the treatment of DOX-induced pulmonary toxicity.Metabolomics, the application of analytical chemistry methodologies to survey the chemical composition of a biological system, is used to globally profile and compare metabolites in one or more groups of samples. Given that metabolites are the terminal end-products of cellular metabolic processes, or 'phenotype' of a cell, tissue, or organism, metabolomics is valuable to the study of the maternal-fetal interface as it has the potential to reveal nuanced complexities of a biological system as well as differences over time or between individuals. The placenta acts as the primary site of maternal-fetal exchange, the success of which is paramount to growth and development of offspring during pregnancy and beyond. Although the study of metabolomics has proven moderately useful for the screening, diagnosis, and understanding of the pathophysiology of pregnancy complications, the placental metabolome in the context of a healthy pregnancy remains poorly characterized and understood. Herein, we discuss the technical aspects of metabolomics and review the current literature describing the placental metabolome in human and animal models, in the context of health and disease. Finally, we highlight areas for future opportunities in the emerging field of placental metabolomics.Wild fish (Cyprinus carpio, Mugil cephalus, Platichthys flesus) from an estuary of the NE Atlantic coast were investigated for plastic contamination (N = 128). From the 1289 particles recovered from fish samples, 883 were plastics. Among these, 84% were fibres and 97% were microplastics. Thirty-six polymers were identified. The number of microplastics (mean ± SD) per individual fish (MP/fish) was 8 ± 6 in C. carpio, 10 ± 9 in M. cephalus and 2 ± 2 in P. flesus. link2 The means of MP/fish per body site were 6 ± 7 in gastrointestinal tract, 0.5 ± 1.1 in gills, 0.3 ± 0.7 in liver and 0.6 ± 1.2 in muscle samples. A few large fibres in liver (≤ 4841 μm) and muscle (≤ 5810 μm) samples were found. The results evidence the existence of high fish contamination by microplastics and reinforce the need of further research on plastic pollution in estuaries.The combustion efficiency of simulated at-sea surface oil burns (in situ burns) was determined in a 63 m3 tank while testing varied boom configurations and air-assist nozzles in the presence and absence of waves. Combustion efficiencies of Alaska North Slope oil based on unburned carbon in the plume emissions ranged from 85% to 93% while values based on oil mass loss ranged from 89% to 99%. A four-fold variation in PM2.5 emission factors was observed from the test conditions. The most effective burns in terms of reduced emissions and post-burn residue concentration of total petroleum hydrocarbons were those that had high length to width boom ratios resulting in higher flame front surface area exposure to ambient air. The amount of oil mass lost was not related to any combustion efficiency parameters measured in the plume, representing a potential tradeoff between unburnt oil and air pollution.The distribution and enrichment of trace metals in sediments of the South China Sea along the entire coast of Vietnam were described. The concentrations of Cr, Ni, Zn, and Pb in the sediments showed a significant positive correlation with fine-sized fractions and TOC. In contrast, the concentration of As was not positively correlated with particle size and other metals. The relatively positive correlations of Cd with Fe, Al, Ti, Sc, TOC, P, Cr, Ni, Zn, and Pb indicated that it comes from different sources. Ecotoxicological indexes of all elements showed low values, except for Cd in the southwestern part of the South China Sea area, which is likely related to the influx of suspended matter from the Mekong River.Documenting the prevalence of microplastics in marine-coastal ecosystems serves as a first step towards understanding their impacts and risks presented to higher trophic levels. Estuaries exist at the interface between freshwater and marine systems, and provide habitats for a diverse suite of species, including shellfish, fish, and birds. We provide baseline values for estuarine mudflats using sediment samples collected at Cowichan-Koksilah Estuary in British Columbia, Canada, a biologically-rich estuary. The estuary also contains a marine shipping terminal, forestry log sort area, and input of contaminants from nearby residential and agricultural areas. link3 Microplastics, both fragments and fibers, occurred in 93% (13/14) of sediment samples. A mean of 6.8 microfibers/kg dw (range 0-12 microfibers/kg dw) and 7.9 microfragments/kg (range 0-19 fragments/kg dw) occurred in individual samples, and counts of fibers and fragments were strongly correlated (r = 0.78, p = 0.008, n = 14). The abundance of microplastics tended to be higher on the north side of the estuary that receives greater inputs from upland sources relative to the south side. Size distributions of microplastic fragments and fibers were similar to sediment grain size distribution with size categories 0.063 to 0.25 mm and 0.25 to 0.6 mm being the most common for plastics and sediment, indicating the occurrence of microplastics likely followed existing depositional processes within the estuary. Microplastics in sediments were composed of a variety of polymers, including high density polyethylene (HDPE), Nylon 6/6 (polyhexamethylene adipamide), and polyethylene terephthalate-PETE (poly(1,4-cyclohexylene dimethylene terephthalate)). This study indicates that microplastics occur throughout most of the Cowichan-Koksilah Estuary, and future studies should focus on the exposure risk and potential for bioaccumulation for wildlife species that feed on the surface of intertidal mudflats.Mediterranean waters are particularly vulnerable to plastic pollution, with plastic particles concentrations comparable to those found in oceanic gyres. This work aimed to assess the impact of polymethylmethacrylate nanoplastics (PMMA-NPs) on the most important mucosal barriers of the gilthead seabream (Sparus aurata), a highly consumed fish species in the Mediterranean area. Fish were waterborne exposed to NPs (0.001-10 mg/L) for 24 and 96 h, and biochemical parameters associated with oxidative status (total oxidative status and total antioxidant capacity) and immune function (adenosine deaminase, ADA, acetylcholinesterase activity, AChE, and esterase activity, EA) were assessed in gills, intestine, and skin. In intestine, PMMA-NPs led to oxidative status alterations and decreased ADA and EA. In gills, PMMA-NPs induced EA decrease and AChE activity increase. Total protein values were significantly increased in skin. Overall, more alterations were observed in intestine, suggesting it may be one of the most affected tissues by exposure to NPs.
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