Notes

Cattail fibers as supply of cellulose to organize a novel type of blend aerogel adsorbent to the removal of enrofloxacin inside wastewater.
01). The effect of therapeutic exercises on functional independence was insignificant (WMD 1.6; 95%CI -1.5, 4.6; p =.31).

Low to moderate evidence from studies of low to high methodological quality provides some support for therapeutic exercises for reducing disease severity among non-hereditary degenerative cerebellar ataxia and improving balance among acquired cerebellar ataxia. Exercises did not benefit functional independence. Additional studies of large sample size and high methodological quality are necessary to substantiate these findings.
Low to moderate evidence from studies of low to high methodological quality provides some support for therapeutic exercises for reducing disease severity among non-hereditary degenerative cerebellar ataxia and improving balance among acquired cerebellar ataxia. Exercises did not benefit functional independence. Additional studies of large sample size and high methodological quality are necessary to substantiate these findings.How do scientists maintain their research programs in the face of not finding anything? Continual failure to produce results can result in declining support, scientific controversy and credibility challenges. We elaborate on a crucial mechanism for sustaining the credibility of research programs through periods of non-detection the maintenance of ambiguity. By this, we refer to scientific strategies that resist closure or an experiment's premature end by creating doubt in negative findings and fostering hope for future positive results. To illustrate this concept, we draw upon the recent history of Martian exobiology. Since the 1960s, planetary scientists have continually tried and failed to find evidence of life on Mars. And yet, interest in extraterrestrial life detection remains high, with more missions to Mars underway. Through three destabilizing events of non-detection, we show how exobiologists sustained the search for Martian life by casting doubt on negative findings, pointing to other possible unexplored routes to success, and finally reconfiguring operations around new methods or goals. New approaches may take the form of shifts in scale, method and object of interest. By pivoting to a different scale, method or object, exobiologists have continued to study a subject continually lacking proof of existence and made important discoveries about life on Earth.We aimed to explore positive and negative associations of consuming alcohol with psychosocial outcomes among colorectal cancer (CRC) survivors. We used data of an observational prospective cohort study, consisting of 2625 Dutch CRC survivors enrolled 1-11 years post-diagnosis that were followed-up in 4 yearly surveys. Generalized estimated equation models were used to examine longitudinal associations between alcohol consumption and anxiety, depression, and health-related quality of life (HRQoL), while correcting for sociodemographic, lifestyle and clinical characteristics. Compared to lifetime abstainers, former alcohol consumption was associated with more depressive symptoms, and worse global quality of life and social functioning, while current drinking was associated with less anxiety, depression and better HRQoL. More drinks per week was associated with less nausea/vomiting. Compared to abstainers, moderate (≤7 drinks/week) and heavy alcohol consumption (>7 drinks/week) were associated with less anxiety and depression and better HRQoL, mostly attributable to wine consumption. Whereas current alcohol consumption was longitudinally associated with less anxiety and depression and better HRQoL, former drinking was associated with worse psychosocial outcomes, although based on a small sample size. It is important to consider that besides the potential negative effects of alcohol on patients' health, alcohol consumption may be positively related with psychosocial outcomes.Supplemental data for this article is available online at https//doi.org/10.1080/01635581.2022.2044063.
To analyze the incidence and mortality of cerebrovascular diseases (CeVD) in Spain from 2001 to 2015.

Retrospective study of hospital incidence, hospital case fatality and population mortality, with records from the Spanish Government Statistics. D609 chemical structure Days of hospital stay and risk of death (RD) during admission were estimated adjusting for age, sex, first stroke (FS), atrial fibrillation (AF), diabetes, hypertension, and smoking.

There were 1,662,487 stroke cases older than 15 years of age admitted to hospital (1,096,748 FS), with a national incidence = 291/10
in this period (Murcia maximum (367/10
), Canary Islands minimum (238/10
)). Population mortality (-50%) decreased while case fatality remained stable (-3%), despite the increase in the age of patients (+2.29 years) and the incidence (+25%). Canary Islands had the youngest patients (-3.5 years for men and -6 years for women) and the longest hospital stay (+5.1 days). Andalusia (odds ratio (OR) = 1.21 (1.19; 1.22)) and the Canaries (OR = 1.18 (1.15; 1.21)) had the highest RD. The factors associated to the highest increases in RD were FS (OR = 1.34 (95% confidence interval (CI) = 1.33-1.35)) and AF (OR = 1.30 (95% CI = 1.29-1.31)).

Population mortality due to CeVD was reduced by half in Spain between 2001 and 2015, but hospital incidence increased. Andalusia and the Canary Islands had the highest RD in the country. These islands presented the lowest incidence, but their patients were younger, and their hospital stay longer. FS and AF were the factors associated with a higher RD.
Population mortality due to CeVD was reduced by half in Spain between 2001 and 2015, but hospital incidence increased. Andalusia and the Canary Islands had the highest RD in the country. These islands presented the lowest incidence, but their patients were younger, and their hospital stay longer. FS and AF were the factors associated with a higher RD.Spatial attention can be captured automatically by an exogenous stimulus (e.g., digital interruption) or by an endogenous stimulus (e.g., valence of the stimulus). In this study, we investigated whether a non-perceptual characteristic (e.g., sense of fluency) has an impact on attention. To this end, we used the conceptual fluency paradigm developed by Whittlesea combined with the dot-probe task developed by MacLeod et al. In three experiments, we measured the response times for each experimental situation (i.e., Valid and Non-valid situations). At each trial, participants were presented in three consecutive displays on a screen (1) an incomplete and predictive sentence stem; (2) a pair of words, one of which was semantically compatible with the previous sentence stem; and (3) a circle appeared at the spatial location of one of the words. Then, participants had to perform a Go (i.e., a filled circle) and No-go (i.e., an empty circle) task. The analysis found that response times were significantly faster when the Go stimulus appeared at the same location as the semantically compatible word (i.e., Valid situations). Overall, our results show that the sense of fluency triggers attentional capture. Thus, they replicate those of Gardner et al. using another experimental paradigm. Our finding might be helpful to better understand the consequences of digital interruptions on behavioural performance.
Since pre-existing expectations, that is, beliefs, in a treatment may modify outcomes, and acupuncture studies often fail to measure expectations, we wanted to investigate the use of acupuncture, interest, and belief in acupuncture effects among patients undergoing cancer therapy.

A cross-sectional design, where the participants answered a study-specific questionnaire with questions regarding their use of, interest and belief in acupuncture treatment.

A total of 457 patients with cancer (48% men, mean age 65 years) answered the questionnaire. Acupuncture was used by 4 (1%) patients during their cancer therapy, and 368 (83%) expressed an interest in receiving acupuncture. Of the 457 patients, 289 (63%) believed acupuncture to be effective for at least 1 of 17 requested symptoms, most commonly pain (56% of the patients) and muscle tension (40%). They believed acupuncture to be effective for a mean value 3 of the 17 requested symptoms. Women (
 < .001), and patients 41 to 65 years (
 < .001), expree available for patients with cancer, for side effects where acupuncture has shown to be effective. In a clinical setting, older men might need more encouragement regarding positive expected outcomes of the acupuncture treatment than younger women.
A proportion of people with treatment-resistant schizophrenia fail to show improvement on clozapine treatment. Knowledge of the sociodemographic and clinical factors predicting clozapine response may be useful in developing personalised approaches to treatment.

This retrospective cohort study used data from the electronic health records of the South London and Maudsley (SLaM) hospital between 2007 and 2011. Using the Least Absolute Shrinkage and Selection Operator (LASSO) regression statistical learning approach, we examined 35 sociodemographic and clinical factors' predictive ability of response to clozapine at 3 months of treatment. Response was assessed by the level of change in the severity of the symptoms using the Clinical Global Impression (CGI) scale.

We identified 242 service-users with a treatment-resistant psychotic disorder who had their first trial of clozapine and continued the treatment for at least 3 months. The LASSO regression identified three predictors of response to clozapine higher a prediction model developed by including routinely collected data, in combination with biological information, presents adequate predictive ability to be applied in clinical settings.
Retrospective, cross-sectional.

To identify trauma patients with confirmed tears of the transverse atlantal ligament on cervical MRI and measure several parameters of atlanto-axial alignment on cervical CT, including the anterior atlantodens interval, to determine which method is most sensitive in predicting transverse atlantal ligament injury.

Adult trauma patients who suffered a transverse atlantal ligament tear on cervical MRI were identified retrospectively. The cervical CT and MRI exams for these patients were reviewed for the following anterior and lateral atlantodens interval widening, lateral C1 mass offset, C1-C2 rotatory subluxation, and transverse atlantal ligament injuries on cervical MRI.

Twenty-six patients were identified with a tear of the transverse atlantal ligament on cervical MRI. Twelve percent of these patients demonstrated an anterior dens interval measuring greater than 2mm, 26% of patients demonstrated lateral mass offset of C1 on C2 (average offset of 2.4mm), 18% of patients rotation were all poor predictors of transverse atlantal ligament tears.
The FAT atypical cadherin 1/2/3/4 (FAT1/2/3/4) has been linked to the occurrence and development of various cancers. However, the prognostic and immunological role of FAT1/2/3/4 in non-small cell lung cancer (NSCLC) has not been clarified.

The association of FAT1/2/3/4 mutations with tumor mutation burden (TMB), tumor immunity in the microenvironment, and response to ICIs in NSCLC was investigated. Whole-exome sequencing data of lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC) samples from the Cancer Genome Atlas (TCGA), and an immunotherapy data set comprising mutation and survival data of 75 NSCLC patients were analyzed. Two independent pan-cancer cohorts with large samples were used to validate the prognostic value of FAT1/2/3/4 mutations in immunotherapy.

A high mutation rate of FAT1/2/3/4 (57.3%, 603/1052) was observed in NSCLC patients. TMB was significantly higher in samples with mutated FAT1/2/3/4 compared to samples with wildtype FAT1/2/3/4 (
< .05). FAT2 mutation was found to be an independent prognostic biomarker in LUAD.
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