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A new algorithm that describes the faradaic current for elementary redox reactions in the cyclic voltammetric responses of persistently adsorbed species on metal electrodes at any scan rate is presented. This work does not assume electrochemical reversibility and instead demonstrates a set of equations that encapsulate how the forward and back charge-transfer rate constants influence the data as a function of the experimental time scale. The method presented here is compared against other approaches that rely on either finite-difference calculations or that require numerical approximation of improper integrals (i.e., ±infinity as a bound). The method here demonstrates that the current-potential data can be described by incomplete gamma functions, whose two arguments capture the relevant kinetic variables. Following the notation for the Butler-Volmer model of charge transfer, exact solutions are presented for the cases of the charge-transfer coefficient, α, equal to 1 or 0. A related algorithm based on these results affords calculation of current-potential data for 0 less then α less then 1, allowing comprehensive analysis (i.e., point by point) of voltammetric data throughout the reversible, quasi-reversible, and irreversible regimes. Accordingly, this work represents an alternative to the method of Laviron, i.e., analyzing just the peak splitting values, for experimentalists to understand and interpret their voltammetric data in totality.A large library of novel porous salts based on charged coordination cages was synthesized via straightforward salt metathesis reactions. For these, solutions of salts of oppositely charged coordination cages are mixed to precipitate MOF-like permanently porous products where metal identity, pore size, ligand functional groups, and surface area are highly tunable. For most of these materials, the constituent cages combine in the ratios expected based on their charge. Additional studies focused on the rate of salt metathesis or reaction stoichiometry as variables to tune particle size or product composition, respectively. It is expected that the design principles outlined here will be widely applicable for the synthesis of new porous salts based on a variety of charged porous molecular precursors.While the low-absorption cross section of lanthanide-based upconversion systems, in which the trivalent lanthanides (Ln3+) are responsible for converting low- to high-energy photons, has restricted their application to intense incident light, the emergence of a cascade sensitization through an organic dye antenna capable of broadly harvesting near-infrared (NIR) light in upconversion nanoparticles opened new horizons in the field. With the aim of pushing molecular upconversion within the range of practical applications, we show herein how the incorporation of an NIR organic dye antenna into the ligand scaffold of a mononuclear erbium coordination complex boosts the upconversion brightness of the molecule to such an extent that a low-power (0.7 W·cm-2) NIR laser excitation of [L6Er(hfa)3]+ (hfa = hexafluoroacetylacetonate) at 801 nm results in a measurable visible upconverted signal in a dilute solution (5 × 10-4 M) at room temperature. GDC-0919 Connecting the NIR dye antenna to the Er3+ activator in a single discrete molecule cures the inherent low-efficient metal-based excited-state absorption mechanism with a powerful indirect sensitization via an energy transfer upconversion, which drastically improves the molecular-based upconverted Er3+-centered visible emission.Phase transition is a promising aspect of DNA as biopolymers. Anionic DNA oligonucleotides easily form complexes with cationic polypeptides such as polylysine, and duplex formation significantly influences their complexation and resulting microcompartments. In this study, phase transition of microcompartments containing DNA and polylysine was systematically induced by modulating duplex formation of arylazopyrazole-conjugated oligonucleotides with light. We demonstrated that UV irradiation destabilized DNA duplex and generated isotropic coacervates, while duplex stabilization by visible light irradiation caused the formation of liquid crystalline coacervates. This photocontrol of phase transition was highly repeatable, and similar changes were observed even after ten cycles of light irradiation. link2 Our approach would provide a robust control layer to the development of tailor-made microcompartments.Contact electrification and the triboelectric effect are complex processes for mechanical-to-electrical energy conversion, particularly for highly deformable polymers. While generating relatively low power density, contact electrification can occur at the contact-separation interface between nearly any two polymer surfaces. This ubiquitousness of surfaces enables contact electrification to be an important phenomenon to understand energy conversion and harvesting applications. The mechanism of charge generation between polymeric materials remains ambiguous, with electron transfer, material (also known as mass) transfer, and adsorbed chemical species transfer (including induced ionization of water and other molecules) all being proposed as the primary source of the measured charge. Often, all sources of charge, except electron transfer, are dismissed in the case of triboelectric energy harvesters, leading to the generation of the "triboelectric series", governed by the ability of a polymer to lose, or accept, an electron. Here, this sole focus on electron transfer is challenged through rigorous experiments, measuring charge density in polymer-polymer (196 polymer combinations), polymer-glass (14 polymers), and polymer-liquid metal (14 polymers) systems. Through the investigation of these interfaces, clear evidence of material transfer via heterolytic bond cleavage is provided. Based on these results, a generalized model considering the cohesive energy density of polymers as the critical parameter for polymer contact electrification is discussed. This discussion clearly shows that material transfer must be accounted for when discussing the source of charge generated by polymeric mechanical energy harvesters. Thus, a correlated physical property to understand the triboelectric series is provided.Isothermal titration calorimetry (ITC) is a widely used method to determine binding affinities and thermodynamics in ligand-receptor interactions, but it also has the capability of providing detailed information on much more complex events. However, the lack of available methods to analyze ITC data is limiting the use of the technique in such multifaceted cases. Here, we present the software ANISPROU. Through a semi-empirical approach that allows for extraction of quantitative information from complex ITC data, ANISPROU solves an inverse problem where three parameters describing a set of predefined functions must be found. In analogy to strategies adopted in other scientific fields, such as geophysics, imaging, and many others, it employs an optimization algorithm which minimizes the difference between calculated and experimental data. In contrast to the existing methods, ANISPROU provides automated and objective analysis of ITC data on sodium dodecyl sulfate (SDS)-induced protein unfolding, and in addition, more information can be extracted from the data. Here, data series on SDS-mediated protein unfolding is analyzed, and binding isotherms and thermodynamic information on the unfolding events are extracted. The obtained binding isotherms as well as the enthalpy of different events are similar to those obtained using the existing manual methods, but our methodology ensures a more robust result, as the entire data set is used instead of single data points. We foresee that ANISPROU will be useful in other cases with complex enthalpograms, for example, in cases with coupled interactions in biomolecular, polymeric, and amphiphilic systems including cases where both structural changes and interactions occur simultaneously.A tungsten-catalyzed hydroboration of unactivated alkenes at distal C(sp3)-H bonds aided by native directing groups is described herein. The method is characterized by its simplicity, exquisite regio- and chemoselectivity, and wide substrate scope, offering a complementary site-selectivity pattern to other metal-catalyzed borylation reactions and chain-walking protocols.A series of thorium(IV) complexes featuring the redox-active 4,6-di-tert-butyl-N-(2,6-di-isopropylphenyl)-o-iminobenzoquinone (dippiq) ligand family have been synthesized and characterized. The neutral iminoquinone ligand was used to generate Th(dippiq)Cl4(dme)2 (1-iq) and Th(dippiq)2Cl4 (2-iq), both of which show dative bonds between the thorium(IV) ion and the ligands. link3 One electron reduction of the ligand forms the unique tris(iminosemiquinone) complex, Th(dippisq)3Cl (3-isq), which features a radical in each ligand. Further reduction furnishes the amidophenolate species, Th(dippap)3]K2(THF)2 (4-ap), which has the ligands in their dianionic form. Attempts to sequester the potassium ions with cryptand resulted in the [Th(dippap)3K][K(crypt)] (4-ap mono crypt) and [Th(dippap)3][K(crypt)]2 (4-ap crypt) species. A bis(amidophenolate) complex was accessed by incorporating bulky triphenylphosphine oxide (OPPh3) ligands to generate Th(dippap)2(OPPh)3 (5-ap). Spectroscopic and structural characterization of each derivative established the +4 oxidation state for thorium with redox chemistry occurring at the ligands rather than the thorium ion. The reported 3-isq complex is unprecedented as it is the first tri(radical) thorium complex with the highest reported magnetic moment for a thorium species as characterized by SQUID magnetometry.Histones are the alkali proteins in eukaryotic somatic chromatin cells which constitute the nucleosome structure together with DNA. Their abnormality is often associated with multiple tumorigenesis and other human diseases. Nevertheless, a simple and efficient super-resolution method to visualize histone distribution at the subcellular level is still unavailable. Herein, a Zn(II) terpyridine complex with rich-electronic azide units, namely, TpZnA-His, was designed and synthesized. The initial in vitro and in silico studies suggested that this complex is able to detect histones rapidly and selectively via charge-charge interactions with the histone H3 subunit. Its live cell nuclear localization, red-emission tail, and large Stokes shift allowed super-resolution evaluation of histone distributions with a clear distinction against nuclear DNA. We were able to quantitatively conclude three histone morphology alternations in live cells including condensation, aggregation, and cavity during activating histone acetylation. This work offers a better understanding as well as a versatile tool to study histone-involved gene transcription, signal transduction, and differentiation in cells.Biomass pretreatment methods are commonly used to isolate carbohydrates from biomass, but they often lead to modification, degradation, and/or low yields of lignin. Catalytic fractionation approaches provide a possible solution to these challenges by separating the polymeric sugar and lignin fractions in the presence of a catalyst that promotes cleavage of the lignin into aromatic monomers. Here, we demonstrate an oxidative fractionation method conducted in the presence of a heterogeneous non-precious-metal Co-N-C catalyst and O2 in acetone as the solvent. The process affords a 15 wt% yield of phenolic products bearing aldehydes (vanillin, syringaldehyde) and carboxylic acids (p-hydroxybenzoic acid, vanillic acid, syringic acid), complementing the alkylated phenols obtained from existing reductive catalytic fractionation methods. The oxygenated aromatics derived from this process have appealing features for use in polymer synthesis and/or biological funneling to value-added products, and the non-alkaline conditions associated with this process support preservation of the cellulose, which remains insoluble at reaction conditions and is recovered as a solid.
Website: https://www.selleckchem.com/products/navoximod.html
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