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penyebab primer adalah kondisi yang tanpa kehadirannya suatu gangguan tidak akan muncul. Misalnya pada orang yang terkena Sifilis atau raja singa adalah infeksi yang disebabkan oleh bakteri yang bernama Treponema pallidum. Sifilis adalah infeksi menular seksual yang bersifat kronis. Jika infeksi sifilis yang menyerang sistem saraf pada kasus paresis general yaitu sejenis psikosis yang disertai paralysis atau kelumpuhan yang bersifat progresif atau berkembang secara bertahap sampai akhirnya penderita mengalami kelumpuhan total. Tanpa infeksi sipilis gangguan ini tidak mungkin menyerang seseorang. Contoh lain juga yang terdapat dalam bidang psikologi adalah kecemasan yang terjadi ketika seorang anak masih kecil. kecemasan itu akan dapat memunculkan gangguan seperti terjadinya gangguan jiwa atau penyimpangan perilaku.
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