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Anti-Cancer Influence Of Xao Tam Phan Paramignya Trimera Methanol Root Extract On Human Breast Cancer




Xao tam phan (Paramignya trimera (Oliv.) Guillaum) is a Vietnamese traditionally medicinal plant employed in the treatment of numerous cancers. The preparation of Xao tam phan extracts including solvent type and extraction method have significant effects on extraction efficiency, phytochemical profile and biological activity. This research aimed to analyze the end results of five various solvents (water, acetonitrile, methanol, ethyl acetate and hexane) and three different extraction methods (conventional, ultrasound-assisted and microwave-assisted) on phytochemical yield and antioxidant capacity of P. trimera root from Vietnam. The outcomes indicate that methanol extracted the maximal yield of phytochemicals from P. trimera and exhibited the highest antioxidant capacity, with eleven compounds were identified and quantified. Microwave-assisted extraction produced the maximal phytochemical yields (with the exception of total flavonoids) and antioxidant capacity, in comparison to conventional and ultrasound-assisted extractions. These data show that the application of methanol and microwave-assisted extraction are recommended for extraction of biologically active phytochemicals from P. trimera root for application from the nutraceutical and/or pharmaceutical industries.





Drying methods, solvents and extraction methods greatly impact the phytochemical compounds and biological activity from plant materials. The aims with this study could determine the results of different drying methods, various solvents and extraction methods on the phytochemical compounds and antioxidant capacity from Xao tam phan (Paramignya trimera) root purchased from Vietnam. The results demonstrated that microwave drying was an effective method in eliminating water with regards to shortest drying time, lowest energy consumption and greatest retention of phytochemical compounds and antioxidant capacity through the P. trimera root while methanol and microwave-assisted extraction were the very best solvent and way of greatest extraction with the phytochemical compounds and antioxidant capacity in the P. trimera root. The findings because of this study allow retaining the highest numbers of phytochemical compounds and antioxidant capacity in the P. trimera root for potential application in the nutraceutical industry.


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