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Anti-Cancer Effect Of Xao Tam Phan Paramignya Trimera Methanol Root Extract On Human Cancer Of The Breast




Xao tam phan (Paramignya trimera (Oliv.) Guillaum) can be a Vietnamese traditionally medicinal plant utilized in the treatment of numerous cancers. The preparation of Xao tam phan extracts including solvent type and extraction method have significant effects on extraction efficiency, phytochemical profile and biological activity. These studies aimed to analyze the effects of five various solvents (water, acetonitrile, methanol, ethyl acetate and hexane) and three different extraction methods (conventional, ultrasound-assisted and microwave-assisted) on phytochemical yield and antioxidant capacity of P. trimera root from Vietnam. The outcomes indicate that methanol extracted the maximal yield of phytochemicals from P. trimera and exhibited the greatest antioxidant capacity, with eleven compounds were identified and quantified. Microwave-assisted extraction produced the maximal phytochemical yields (aside from total flavonoids) and antioxidant capacity, when compared to conventional and ultrasound-assisted extractions. These data demonstrate that the usage of methanol and microwave-assisted extraction are suggested for extraction of biologically active phytochemicals from P. trimera root for application from the nutraceutical and/or pharmaceutical industries.





Drying methods, solvents and extraction methods greatly modify the phytochemical compounds and biological activity from plant materials. The aims of the study could determine the effects of various drying methods, various solvents and extraction methods about the phytochemical compounds and antioxidant capacity from Xao tam phan (Paramignya trimera) root purchased from Vietnam. The outcome demonstrated that microwave drying was an efficient method in elimination of water in terms of shortest drying time, lowest energy consumption and greatest retention of phytochemical compounds and antioxidant capacity in the P. trimera root while methanol and microwave-assisted extraction were the very best solvent and way for greatest extraction of the phytochemical compounds and antioxidant capacity in the P. trimera root. The findings from this study allow retaining the greatest degrees of phytochemical compounds and antioxidant capacity through the P. trimera root for potential application within the nutraceutical industry.


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