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More About Could a New Stem Cell Treatment Cure Type 1 Diabetes?


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<p class="p__0">Melton remembered. In time, their child Emma, 4 years older than Sam, would establish the illness too, when she was 14. Dr. Melton had actually been studying frog advancement but abandoned that work, determined to find a cure for diabetes. He relied on embryonic stem cells, which have the prospective to end up being any cell in the body.</p>
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<p class="p__1">One issue was the source of the cells they came from unused fertilized eggs from a fertility center. However in August 2001, President George W. Bush disallowed using federal money for research study with human embryos. Dr. Melton needed to sever his stem cell laboratory from whatever else at Harvard. He got personal financing from the Howard Hughes Medical Institute, Harvard and benefactors to establish a completely different laboratory with an accountant who kept all its expenses different, down to the light bulbs.</p>
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<p class="p__2">Melton estimates the task cost about $50 million. The challenge was to figure out what series of chemical messages would turn stem cells into insulin-secreting islet cells. The work included unraveling typical pancreatic advancement, figuring out how islets are made in the pancreas and carrying out endless experiments to guide embryonic stem cells to ending up being islets.</p>
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<p class="p__3">After years when absolutely nothing worked, a small team of scientists, including Felicia Pagliuca, a postdoctoral scientist, was in the laboratory one night in 2014, doing one more experiment."We weren't very positive," she said. They had put a color into the liquid where the stem cells were growing. The liquid would turn blue if the cells made insulin.</p>
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<p class="p__4">Then she saw a faint blue tint that got darker and darker. She and the others were overjoyed. For the very first time, they had made functioning pancreatic islet cells from embryonic stem cells. The laboratory commemorated with a little party and a cake. Then they had bright blue wool caps made for themselves with 5 circles colored red, yellow, green, blue and purple to represent the phases the stem cells had to pass through to end up being functioning islet cells.</p>
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<p class="p__5">The next action for Dr. Melton, knowing he 'd need more resources to make a drug that might get to market, was beginning a business. A Living Chance was founded in 2014, a mix of Sam and Emma's names. One difficulty was to find out how to grow islet cells in big amounts with a method others might repeat.</p>
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