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MAS is caused by an overactive immune system. Infections trigger both the innate and adaptive immune systems. The innate immune system launches a general response to invaders, whereas the adaptive immune system launches specific antibodies to fight specific organisms. Overactive innate immunity is a common cause of MAS. The innate immune system is comprised of several different types of immune cells that work together to fight infections. Macrophages destroy viruses and bacteria, and T-lymphocytes send signals to gather these immune cells. In some cases, however, the innate immune system does not destroy infectious cells, and this results in the body being flooded with inflammatory cytokines, which can cause damage to any organ.
Mas Viral is highly inflammatory. Interestingly, a recent large multinational study noted that MAS occurs in approximately one-third of patients with sJIA. The disease onset and active disease phases play major roles in triggering MAS. The onset of sJIA is the most common time for a MAS episode. Infections are also known to be a common trigger. Acute infections often lead to a MAS episode.
Homepage: https://masviral.net
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