Notes

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In high doses, Nembutal can slow down the nervous system to the point of slowing your heart rate and breathing. Using the drug in high doses for a long time is more likely to cause more severe symptoms quickly. A carboxylic acid is, therefore, a much stronger acid than the corresponding alcohol, because, when it loses its proton, a more stable ion results. The composition of this type should, therefore, still undergo a significant improvement if it is to use such a drug with a high molecular weight as calcitonin, insulin, and the like. It is clear from FIG. 1 that the compositions in which crystalline cellulose is used show a high efficient absorption of insulin and that the composition in which sodium polyacrylate is used in combination with crystalline cellulose show a high efficient absorption of insulin as well as a sustained release effect. It is clear from Table 2 that the composition of this invention shows a high efficient absorption of insulin. Also, such powdery composition has difficulty in maintaining its effective drug concentration at a high level. This post has been done by G SA　Con tent Generat or DEMO!

It is yet another object of this invention to provide a powdery pharmaceutical composition for nasal administration which allows physiologically active polypeptide or its derivative to be absorbed efficiently through the nasal mucosa and also has a sustained release effect. This pharmaceutical composition is characterized in that its lower alkyl ether of cellulose absorbs moisture on the nasal mucous membrane, and takes the form of a viscous liquid to slowly flow over the nasal mucosa and releases the drug slowly. As the water-absorbing and water-soluble base to be used in this invention, there are, for instance, polyacrylates such as sodium polyacrylate, potassium polyacrylate and amonium polyacrylate; lower alkyl ethers of cellulose such as methyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose and sodium carboxymethyl cellulose; polyvinyl pyrrolidone, amylose, polyethyleneglycol and pullulan. The powdery composition of this invention may have any of the structures such as one in which the water-absorbing and water-insoluble base and polypeptide or its derivative form independent particles, one in which polypeptide or its derivative particles are adhered to the surface of the water-absorbing and water-insoluble base particle, one in which polypeptide or its derivative particles are dispersed in the water-absorbing and water-insoluble base particle, both forming separate phases of their own, or one in which polypeptide or its derivative particles are closely dispersed in the water-absorbing and water-insoluble base particle, thus forming a uniform dispersion.

The powdery composition of this invention, which has a structure in which the water-absorbing and water-insoluble base and polypeptide or its derivative form independent particle or polypeptide or its derivative particles are adhered to the surface of the water-absorbing and water-insoluble base particle, can be prepared by first adding polypeptide or its derivative to a water-absorbing and water-insoluble base, then mixing them by a mechanical process, and finally filtering them to obtain the desired composition with more than 90 wt % its particles preferably measuring 10 to 250 microns in effective diameter. By the terms of water-absorbing and water-insoluble, it is meant that the base has double properties of being water-absorbing and water-insoluble on the human nasal mucous membrane or in a similar environment, or more concretely, it is water-absorbing and water-insoluble at pH around 7.4 and at a temperature of 36° C. to 37° C. or thereabout. More specifically, two vertebral bodies and an intervertebral disc located therebetween comprise a motion segment: a function unit at the spine. ibogaine hydrochloride propose to study these two protocols in children ages 6 months to 6 years presenting to the ambulatory procedure center for non-painful procedural sedation. Now consider two possibilities.

Special caution: Barbiturates and benzodiazepines are Central Nervous System depressants that slow heart rate and breathing and reduce blood pressure. For instance, such peptide hormones as insulin, angiotensin, vasopressin, desmopressin, felypressin, protirelin, luteinizing hormone releasing hormone, corticotropin, prolactin, somatropin, thyrotropin, luteinizing hormone, calcitonin, kallikrein, parathyrin, glucagon, oxytoxin, gastrin, secretin, serum gonadotrophin, growth hormone, erythropoietin, angiotensin, urogastrone and renin; such physiologically active proteins as interferon, interleukin, transferrin, histaglobulin, macrocortine and blood coagulation factor VIII; such enzyme proteins as lysozyme and urokinase; such vaccines as acellular and cellular pertussis vaccine, diphthelia vaccine, tetanus vaccine, influenza vaccine; and such toxoids as diphthelia toxoid, tetanus toxoid and toxoids of lymphocytosis promoting factor, and filamentors hemagglutinin (those are contained in acellular pertussis vaccine developed recently in Japan) may be mentioned. As the desirable examples of water-absorbing and water-insoluble base, the following ones may be mentioned. The following comparative compositions were obtained to compare with the compositions of this invention. Other objects and advantages of this invention will become apparent from the following description. It is expected the facility will be operational within a month, although a full service clinic would only be possible if the Bill passes through both both Houses of Parliament.
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