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Radiation Treatment in Mesothelioma
Radiation therapy could be a component of the pleural cancer patient's treatment plan. It may reduce the chance that cancer will come back after surgery.
Radiation therapy utilizes radio waves that ionize, which cause damage to DNA within cells, killing them. It is available prior to or after surgery.
Doctors often combine chemotherapy with it to improve the success of surgery. It also helps reduce symptoms like shortness in breath by shrinking tumors.
External beam radiation therapy (EBRT)
This treatment uses x-rays or particles from a machine that are outside the body to kill cancer cells. It can be administered prior to or after chemotherapy and surgery to destroy cancerous cells in the area, and as palliative therapy to ease symptoms such as shortness of breath. Mesotheliomas do not grow as a single distinct tumors, therefore it can be difficult to target radiation at them while protecting healthy tissues. Newer techniques are helping overcome this problem.
Radiation experts create detailed pictures using a computer of the cancerous tissue and healthy tissues around. These images enable them to determine how much radiation they need to use and where to apply it. This information is used to guide the large machine to position the radiation beam precisely over the tumor. Some patients may need less treatments, but the majority of treatment sessions are five per week over several weeks. Each session is between 15 and 30 minutes. However, the majority of time is spent preparing the patient for the treatment.
The kind of EBRT that is used for mesothelioma varies on the location of the tumor and the patient's health. It could be a standard EBRT known as three-dimensional conformal radiotherapy (3D-CRT) or an advanced technique such as intensity modulated radiation therapy (IMRT). In some cases it may be combined a specialized treatment method, such as stereotactic radiation therapy for larger tumors or with other treatment methods such as intraoperative radiation therapy for smaller tumors which cannot be removed by surgery.
Proton beam radiation therapy is another option for radiation treatment. It involves aiming beams of particles, such as protons or heliumions, towards the site of the tumor from different angles. This allows for more precise focusing of the tumour site and reduces the risk of the damage to healthy tissues and organs in the vicinity. However, proton beam radiation therapy isn't widely employed in Australia for mesothelioma.
A different type of radiation, intraoperative radiation therapy (IORT) is utilized in conjunction with surgery to try and eliminate any mesothelioma that could not be surgically removed. This is a quick procedure that takes just some minutes to perform.
Intensity-modulated radiation therapy (IMRT)
For patients with pleural mesothelioma, IMRT allows the doctor to treat the tumor, while protecting healthy tissue. The treatment is performed using a medical linear acceleration (LINAC) device that emits photons or X-rays to target the tumor. The machine rotates to allow the beam to be positioned at different angles, so that all areas are treated. This allows the doctor to deliver more doses to the tumor, while protecting the surrounding healthy tissues from being damaged.
IMRT is often used in conjunction with Image-Guided Radiation Therapy (IGRT), which helps the physician to target the exact area of cancer. IGRT uses computerized images, such as CT scans, Xrays and MRI scans if available, to assist the radiation oncologist pinpoint mesothelioma in a precise manner. Once the target area has been identified, the IMRT can be used to develop an treatment plan that targets the mesothelioma in a precise manner.
The IMRT system also allows the doctor to tailor the treatment according to the specific anatomy of each patient and reduce the risk of adverse effects. Typically, the radiation oncologist gives the patient five daily IMRT sessions each week for five to eight weeks. Each session lasts between 15 to 30 minutes. The small amount of radiation that is given on a daily basis helps to reduce the damage to the body's normal tissues. It is also important to note that a weekend rest break is often necessary so that the body's healthy tissues can recover.
The IMRT technique produced positive results for patients with mesothelioma of the neck and head. It is particularly beneficial for tumors located near radiosensitive structures like the parotid glands. a recent study showed that IMRT allows a significant dose to be delivered to the tumor without affecting the neighboring parotid gland. The parotids protected were able to recover to 63% of their pre-treatment levels compared to 3% for patients who received conventional radiation. This is a promising outcome however, more research is required. Large-scale studies using IMRT will be needed to confirm the preliminary findings.
Brachytherapy
If doctors are unable to remove mesothelioma in its entirety the radiation treatment can help shrink the tumor and lessen symptoms. Palliative care is what this is called. Doctors use it in combination with other treatments such as chemotherapy and neoadjuvant treatments to increase the patient's life time.
Radiation therapy makes use of x-rays from a machine outside of the body to kill cancer cells. With new techniques, such as IMRT, doctors can target the cancerous area and limit the damage caused by radiation to surrounding tissues.
Certain forms of radiation may also be used inside the body to kill cancerous cells. In brachytherapy, doctors place an enclosed source of radioactive material in or near mesothelioma. This is done via a catheter or an applicator. Doctors can administer radiation doses using a device located outside the body to target the source. This is called external beam radiation therapy (EBRT).
In brachytherapy treatment, doctors can provide patients with either pulsed-dose or high-dose rates of radiation. With the former treatment, patients are admitted to the hospital and receive 10-minute sessions every day for a period of two weeks. High-dose brachytherapy is a procedure that requires a larger machine with longer exposure time, is not as popular.
Protons are employed in a different kind of brachytherapy that is not the x-rays. Because they are physical particles, protons are not absorbed by tissues as easily and can cause less damage to the surrounding area. However, this kind of radiation is more expensive and isn't as widely accessible as x-rays.
Mesothelioma patients might need to undergo radiation therapy for several weeks or more. This could be very difficult to endure. Patients should talk to their doctors about what adverse effects they could experience during treatment. They should also ask their doctor for tips on minimizing adverse effects.
As part of a multimodal plan for treatment mesothelioma patients may also benefit from genetic therapy and immunotherapy. Immunotherapy boosts the immune system and mesothelioma patients who have undergone chemo can benefit from immunotherapies to improve their chemotherapy regimen.
Researchers are also looking for other ways to improve the outcomes of radiation treatments for mesothelioma. One option is to combine brachytherapy with immunotherapy by injecting cells that are infused with the drug Yervoy into the chest cavity. This treatment has proven to be effective in clinical trials. Gene therapy is an alternative approach that involves replacing genes in mesothelioma cancer cells or repairing them to suppress their growth and make them more susceptible to chemotherapy.
Radiation therapy after surgery
Radiation therapy does not cure mesothelioma, but it can improve the outlook of the patient. If used as part a multimodal treatment plan, radiation can shrink mesothelioma tumors, and reduce pain and discomfort caused by cancer. It can also lower the risk of mesothelioma cancer cells expanding during surgery or after the removal of the lung tumor (known as seeding).
Each session lasts about 30 minutes. The treatment can be uncomfortable because the radiation oncologist will need to hold and position the patient in place.
Before the session begins, patients are advised to dress comfortably. Avoid wearing metal as it can interfere with the precision and accuracy of the equipment. Patients should also consume six small, frequent meals to prevent nausea.
Depending on the patient's medical condition, patients can be offered a standard or brachytherapy type of radiation. In conventional treatments doctors utilize a machine known as a linear accelerator to deliver the radiation. This is the most common mesothelioma treatment. It is generally used to treat mesothelioma pleural that grows on the lining of the lung.
Brachytherapy is an improved treatment that makes use of the radiation source that is placed within the body. The implant can be placed temporarily or permanently. When inserting the implant, the doctor must ensure that only cancerous tissue is targeted and not the surrounding organs.
In mesothelioma stage 3 treatment are exploring the possibility of the possibility of combining radiation therapy and surgical procedures for patients suffering from mesothelioma that is resectable. One example is the SMART trial. This treatment plan for experimental purposes involves giving patients hemithoracic radiotherapy prior to they undergo extrapleural pneumonectomy (EPP). This combination of treatments enables doctors to provide patients with greater doses and decrease the risk of post-surgical mesothelioma seeding.
A mesothelioma survivor may experience a complete or partial remission, which means that the tumor has diminished in size or disappeared entirely. Some patients have been in remission for several years and have survived past their original prognosis.
Website: https://www.mesotheliomatreatment.top/
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