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20 Fun Details About Tumor Treating Fields Mesothelioma
Tumor Treating Fields Mesothelioma

Tumor treating mesothelioma caused by fields is a brand new therapy that makes use of alternating electrical fields to limit cancer growth. It is used in combination with chemotherapy to treat pleural cancer.

The FDA approved TTFields together with pemetrexed as well as Cisplatin in the year 2019 following the success of the STELLAR trial. Patients can ask their specialist for this treatment.

Disrupting Cell Division

TTFields employ different electrical fields to disrupt cancer cell proteins and stop their cells from growing. This may stop mesothelioma cancer cells from expanding or spreading to other organs in the body. The TTFields also help to increase the production of proteins that can eliminate cancer cells and aid the immune system fight mesothelioma tumors.

During treatment the patient wears an insulated device that is small in size. pads that are bonded to the skin. The device is able to deliver a low-intensity electrical current, and patients are able to decide the extent of treatment they receive. The mesothelioma treatment typically lasts 30 minutes. Patients can receive TTFields treatment multiple times a day.

A TTFields study that was published in 2021 discovered that the intensity of electrical fields of 100 to 300 kilohertz was able to stop the division of cancer cells and cause them to die. The study included different types of cancer cells and discovered that electrical fields killed all of them, regardless of the cell's structure.

The study's author suggested combining TTFields and chemotherapy for mesothelioma. Novocure's TTFields product, NovoTTF-100L, was approved by the FDA in 2019 to treat pleural mesothelioma that is not resectable. It is now available from mesothelioma specialists from accredited medical centers in the U.S. including the West Cancer Center, Memphis. The NovoTTF 100L device, also known as Optune Lua has been used in the treatment of mesothelioma when combined with platinum-based chemotherapy and pemetrexed. Mesothelioma patients have reported an prolonged survival rate when the TTFields treatment is paired with chemotherapy.

Another study published in "Lung Cancer", reported that TTFields therapy is highly effective in conjunction with chemotherapy. In the trial researchers discovered that the combination of chemotherapy and TTFields reduced the amount of mesothelioma malignancies in animals by more than 80 percent. The study also demonstrated that combining these two treatments increased the production of proteins that kill mesothelioma cells and decrease the amount of cancerous DNA that is found in the body.

Although it is a new treatment, a lot of mesothelioma doctors do not offer TTFields to treat pleural mesothelioma. Patients can still have access to this treatment through clinical trials or at Novocure-certified mesothelioma clinics.

Stalling Tumor Growth

Mesothelioma forms when mesothelial cells mutate and outlive their normal lifespan, leading to an overabundance of cancerous cells that expand and multiply throughout the body. Treatment fields for mesothelioma stop tumors from growing and spreading by blocking mesothelial cells from duplicated.

The TTFields device, worn on the chest as a vest, produces a series electrical fields that destroy proteins and cancer cells and slow down tumor development. The device comes with insulated pads that stick to the skin and can be used at home by patients or health professionals who have been trained by Novocure.

Doctors suggest mixing TTFields with chemotherapy to achieve the best results. The combination increases the production of proteins that kill cancer cells, and reduces the capacity of cancer cells to repair DNA damage caused by chemotherapy drugs. This makes chemotherapy drugs work even harder, and increases the survival rate of mesothelioma patients.

In mesothelioma natural treatment , a combination of TTFields therapy and chemotherapy significantly increased the survival rate for mesothelioma patients. The FDA approved the NovoTTF-100L System and is now marketed as Optune Lua, for use in conjunction with pemetrexed and carboplatin and cisplatin as a first-line treatment for unresectable malignant mesothelioma pleural in the year 2019.

Researchers have found that the TTFields treatment can fight mesothelioma through preventing cell division. The treatment TTFields induces cancer cells to break up in a process known as mitosis. After that, the cell debris is absorbed by surrounding tissues, preventing the development of new tissues. Mitosis prevents mesothelioma cancer cells from repairing damaged genetic material and makes them more prone to radiation treatment.

The TTFields treatment is also able to reduce the flow of blood to tumors by reducing vascular endothelial growth factor, or VEGF, and increasing hypoxia-inducible factor-1 beta, or HIF-1a. This is associated with cancer cell angiogenesis.


If you are diagnosed with mesothelioma, talk to your physician about whether TTFields is a good option for you. Novocure and mesothelioma experts are working together on clinical trials to evaluate the efficacy of TTFields. To find out more about how mesothelioma TTFields could aid your treatment, contact a Novocure-certified specialist at one of more than 1,300 U.S. treatment centers.

Killing Tumor Cells

Tumor treating fields (TTFields) which transmit electrical waves throughout the body to disrupt cell division and kill cancerous cells. The TTFields target cancerous cells while not causing harm to healthy cells. These electric fields also reduce DNA repair and boost the immune system of cells, making it harder for cancerous cells to survive. TTF is non-invasive and has only mild adverse effects.

Scientists believe TTFields function by disrupting mitosis, which is the process through which the cell divides into two identical new cells. Normal cells have mechanisms to restrict mitosis. However cancerous tumors of malignancy are able to break these limitations and multiply at a rapid rate. TTFields interferes with this process by blocking the signals that regulate the process of mitosis in mesothelioma cancer cells. In the STELLAR research, TTFields when combined with chemotherapy significantly increased survival rates in mesothelioma patients. Mesothelioma patients who received TTFields in addition to maintenance cycles of chemo had an average survival time of six months longer than patients receiving only chemotherapy.

A separate study has found that TTFields may increase the effectiveness of certain chemotherapy drugs, known as platinum-based therapies. These platinum-based treatments eliminate mesothelioma cells by targeting mitochondria, which is where cancerous cells get their energy. When TTFields are used in combination with these chemotherapy treatments, it could result in more DNA damage and more rapid death of cancer cells.

In some instances, TTFields may also enhance the effects of radiation therapy. Researchers have observed that when you combine TTFields and radiation therapy can result in the "synergistic" effect. This means that the combination treatment increases the sensitivity of tumor cells to radiation.

Currently, TTFields are only available at some mesothelioma centers. A mesothelioma expert will determine if you're suitable for this treatment. If you're eligible, a lawyer for mesothelioma can help you access treatment that includes TTFields with chemotherapy. If you're an active military veteran mesothelioma lawyer could help you get treatment that is covered by your VA health benefits.

Side Effects

The TT fields therapy destroys cancer cells by generating an electrical field that blocks the cell's ability to divide. This could slow down the growth of tumors and stop the spread of cancer to other areas of the body. The TT Fields device is noninvasive. It does not cause pain or damage to the surrounding tissue. This is a completely different method that traditional chemotherapy, which entails radiation and injections into the intravenous vein, which can cause serious side effects.

In an experiment in which patients were who received a combination of TT fields and temozolomide saw survival gains comparable to those who were only treated with chemotherapy. Doctors attributed the increased survival to TT fields capacity to boost the efficacy of chemo and reduce side effects.

Mesothelioma cells can mutate into cancerous cells and replicate in uncontrolled ways to create tumors that infiltrate the organs of your body. By halting the division of cells, mesothelioma therapies like TT fields stop mesothelioma tumor cells from reproducing and limiting your body's normal functions.

In a mesothelioma-related study patients who received TT-fields together with chemotherapy had an average survival rate (18.2 months). Those who received TT fields but not chemotherapy had a rate of 12.1.

Tumor-treating fields can be applied to the pleura or the thin lining that surrounds your lungs, either on your abdomen or chest wall. The device is small enough to be worn up to 18 hours each day, including sleep. Patients can continue their daily lives and work while undergoing treatment.

The TT fields are a great complement with traditional chemotherapy or immunotherapy as well as other mesothelioma treatments. Mesothelioma patients interested in TT should discuss the possibility with their doctor. They can discuss the conditions for eligibility and the potential benefits for each patient's case.

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