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Mesothelioma - What Causes Mesothelioma?

Like all cancers, mesothelioma is difficult to diagnose because its symptoms can resemble other ailments. Early diagnosis and treatment can enhance the chances of survival for a patient.

Asbestos is the primary reason for mesothelioma. Asbestos is a group of minerals that can be broken down into long, thin fibres. When inhaled or consumed asbestos fibers can become stuck in the lining of certain organs.

Exposure to Asbestos

Exposure to asbestos is the most proven cause of Mesothelioma. Asbestos is a natural mineral that consists of strong, microscopic fibers. It was extensively used in buildings, vehicles, and dozens other construction products between the 1930s and the beginning of the 1980s because it was impervious to water, fire, and sound. The manufacturers of asbestos-based products were aware that it was harmful to health, but they did not inform the public.

The greatest exposure risk was for those who directly handled asbestos-related products. People working in mining, asbestos removal, shipbuilding and other industrial jobs were exposed to large quantities of asbestos. Asbestos-containing materials, such as shingles, pipes and glues and the talcum powder, were utilized in the home by people who were also exposed. In the United States, chrysotile asbestos is the most popular type of asbestos employed. Other types of asbestos such as amosite or Crocidolite have also been associated with mesothelioma.

Mesothelioma symptoms are typically not likely to appear until years after exposure to asbestos. When symptoms do show up it is possible for the disease to advance and become fatal. The symptoms are most commonly seen in the lung (pleural mesothelioma) but they can also affect the lining of the stomach, heart or testicles.

When asbestos fibres are inhaled or swallowed they adhere to cells that are found in the body's internal organs and tissues. As time passes, this causes genetic mutations that lead to cancer. The cells that are affected multiply uncontrollably, forming tumors.

Workers in areas that have high exposure to asbestos are at higher risk of developing mesothelioma compared to those who aren't. Those at greatest risk are those who worked in blue-collar jobs or were in the military. But mesothelioma is a possibility in women who were exposed to asbestos, in particular when they cared for relatives who were exposed to asbestos at work.

Secondary exposure can occur when someone who is at risk of mesothelioma brings asbestos fibers home on their clothing and clothing. cause of mesothelioma lung cancer has been the case for spouses of people exposed to asbestos as well as hairdressers and ceramics workers. Some studies have revealed that a mineral similar to asbestos, erionite, increases the risk of mesothelioma, however this has not been confirmed elsewhere.

Exposure to Minerals

Mesothelioma is a result of the transformation of cells that line specific parts of the body, like the chest lining (pleura) and abdominal cavities. Mesothelioma can also affect the heart's lining (pericardium) or in the testicles (tunica vaginalis). The disease is often associated with asbestos exposure, but other causes can also be responsible.

Asbestos is a mineral that occurs naturally composed of strong and microscopic fibers. It was utilized in building materials, automobile brakes and a variety of other products from the 1930s until the 1980s, due to its resistance to water, fire and sound. Many people employed in the construction industry or in the military were exposed. Workers who handled and removed asbestos were especially at risk for breathing in asbestos-containing particles.

The specific mesothelioma risk is based on the job however any exposure to asbestos increases the risk of developing the disease. Mesothelioma has been linked to all kinds of industries and occupations, but most often, it occurs in millers, miners, shipyard workers and asbestos producers. It has been found in those who work in the manufacturing line of aircraft and automobiles and also in those who handle or sand insulation.

The onset of mesothelioma is usually slow, but it can take between 20 and 60 years for symptoms to appear after exposure to asbestos. Even if you've never been exposed to asbestos, it's important to speak to your doctor about mesothelioma. The earlier cancer is detected the easier it is to treat it successfully.

In the past, a lot of people who developed mesothelioma did not be diagnosed until their disease had advanced. Because mesothelioma cancer is rare doctors often ignore symptoms such as persistent coughing or breathing difficulties.

Asbestos was eliminated in the 1980s, however those who were in the military or worked in industries prior to that remain at a higher risk of developing mesothelioma. Researchers have recently uncovered other kinds of exposure to mineral which increase the risk of mesothelioma. For instance, a mineral called erionite is found in the soil of certain regions in Turkey and is used to make the materials in the area. In studies of the local population heavily exposed to erionite men are more likely than women to develop mesothelioma. In Italy the same thing has been observed in relation to a different mineral called fluoroedenite.

Genetics

Mesothelioma can be described as a cancer that affects mesothelium. It is most prevalent in the lining of the chest cavity (pleura) however it can also affect the tissue around the abdomen, the heart and testicles.

Doctors have linked mesothelioma with the mutation in the gene known as BAP1. This gene regulates the process of putting calcium into cells. If it is altered, the person is at a greater risk chance of developing cancerous cells. Researchers have discovered that BAP1 mutants are found in 70 percent of mesothelioma patients. This discovery has made it easier for doctors to diagnose mesothelioma and increase screening for the disease, particularly in people who have an asbestos-related family history. exposure.

Researchers have also identified other genetic mutations which may result in mesothelioma development. These mutations have also helped mesothelioma experts better understand the disease and how to manage it.

Asbestos is the primary risk factor in mesothelioma. Genetics can also play a part. Some people exposed to asbestos don't develop cancer, however others who do not have a genetic predisposition could develop mesothelioma during a lengthy period of exposure. Secondary exposure or paraoccupational asbestos exposure can occur when coworkers who have been exposed to asbestos take fibers home on their clothing and skin.

In some instances, mesothelioma is found to run in families due to a combination of asbestos and genetics. Most mesothelioma appears to be a random disease and doesn't appear to have any family history.


Asbestos related mesothelioma can be a serious illness. But, research continues to make significant improvements in the treatment of patients and their treatment options. Asbestos is now banned in many countries around the world and scientists are constantly improving mesothelioma treatments with more effective drugs, better specific surgeries, and more efficient diagnostic tests. To learn more about these recent advances, request a free copy of the Mesothelioma Guide. This comprehensive guide contains an exhaustive list of treatment options for mesothelioma that include the most up-to-date clinical trials and promising alternatives. Download the guide by filling out our online form or calling directly.

Lifestyle

Mesothelioma affects the cells that line specific parts of the human body, such as the lungs and abdomen. The liner of your chest cavity (the Pleura) is where the majority of mesothelioma cases begin. However, it could also start in the lining that surrounds the heart and abdomen (the Pericardium).

While asbestos exposure is the primary risk factor for mesothelioma other factors, such as the person's age or gender, can increase the likelihood of developing the disease. Certain risk factors, like smoking cigarettes or gender can change, whereas others, like the age of the person or their family history aren't.

Most people diagnosed with mesothelioma have a family history of the disease, and a lot of them have had long-term exposure to asbestos during their job. Most people diagnosed with pleural or peritoneal cancer are older than 45. This is because it takes mesothelioma many years to develop, and the symptoms can start to appear as an older person.

There are a variety of tests that doctors employ to detect mesothelioma including a CT scan (computerised tomography) or FDG-positron emission (a test that uses the use of a radioactive substance to assess the extent of the tumor's growth) and a biopsy. A biopsy is the process of removing some of the tissue for examination under a microscope, and can be performed by using VATS (Video-assisted surgery using thoracoscopic instruments), a type of keyhole procedure or a needle that is guided by a CT scan.

Doctors can also test a person's blood for a genetic defect called BAP1. This mutation is in a gene that blocks the growth of tumors and makes an individual more susceptible to malignancies resulting by environmental toxins. People with this mutation are more likely to develop mesothelioma when they have experienced relatively low levels of asbestos exposure. Additionally, they have a shorter latency period than those without the genetic mutation. Researchers aren't aware of how prevalent this mutation in the general public is or if it can be prevented by lifestyle choices such as avoiding exposure to toxic substances. This is an area of ongoing research.

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