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Mesothelioma Caused by Arsenic

Arsenic can trigger symptoms such as pins and numbness of the fingers and hands as well as a garlic-like scent on the breath and skin and changes in the skin's pigmentation. It can also increase the risk of lung carcinoma.


Arsenic is usually taken up through water that is contaminated and food items. It can also be found in the workplace, as a result of working on asbestos-related projects.

Causes

Arsenic is an element naturally occurring that is found in a variety of regions of the world's ecosystem. It is necessary for the human body to function, however excessive exposure can lead to serious health problems. Exposure to asbestos for long periods of time can cause cancer and heart disease, along with mesothelioma and lung conditions. Exposure can occur when workers work in certain industries, or eat foods that are contaminated. This element is also found in soil and in water, particularly in areas where smelting and mining have occurred.

Inorganic arsenic can be found at high levels in groundwater of many countries including Argentina, Bangladesh, China, India and Mexico. The most frequent exposure occurs through drinking water contaminated by arsenic or eating crops that were irrigated using arsenic-contaminated water. It is consumed in the form or seafood, shellfish meat or dairy products.

Although short-term exposure to arsenic can trigger symptoms like skin coloration nausea, vomiting, diarrhea and weakness, the most dangerous consequences are associated with long-term or chronic exposure. It is linked to a higher incidence in kidney, bladder and skin cancers. Diabetes and heart disease are also associated. Exposure can also affect a person's mental capabilities and intelligence.

Arsenic can interfere with the body's endocrine systems, according to research. The system that regulates the endocrine gland is responsible for maintaining homeostasis and guiding growth and development, so interference can have far-reaching consequences. Scientists have discovered that even low levels can affect the endocrine system and trigger many health problems.

The exposure to arsenic can occur in the workplace if workers are using a product that has the substance, like wood treatment or pesticides containing metal chemicals. Arsenic can also be consumed in water or food that is contaminated such as rice. TOXMAP is a popular online tool that offers information about arsenic contamination in the United States. does asbestos cause mesothelioma contains maps of the United State and information on chemical releases made by government agencies. Local testing services are available to test for arsenic.

Signs and symptoms

Mesothelioma, a rare cancer, can affect the linings of organs within the body such as the lungs. It can take years to develop and is most often diagnosed in patients who have been exposed to asbestos. Patients may experience a variety of symptoms, such as chest pain, coughing and breath shortness. Making sure you have a mesothelioma-specific diagnosis is the first step towards receiving treatment that can increase life expectancy and improve quality of life. A mistake in diagnosis can stall the process and cause an inexplicably long wait to receive effective treatments.

The latency period of lung cancer caused by arsenic is different from that of asbestos and radon. The carcinogen affects cells in different ways. Asbestos, radon and arsenic target the cells that line lungs. Arsenic targets the cells of other parts. This as revealed by a recent study, may explain why the risk of developing cancer caused by arsenic remains high even after exposure has ended.

This study focused on people living in northern Chile who were exposed to high levels arsenic through their water supply. In the 1950s, river water with arsenic at high levels was diverted for 13 years to Antofagasta. This led to an increase in cancer incidence, including lung and bladder cancers for 13 years beginning in the 1950s.

Other minerals, like tin and lead, can also cause mesothelioma. Asbestos fibres are microscopic and can easily be breathed in. These fibres can cause irritation to the lungs, and can cause abnormal cancer cells. It usually takes 20 to 60 years for mesothelioma to develop after exposure to asbestos.

Doctors use several tests to diagnose mesothelioma. They include physical examinations and blood tests, as well as imaging scans. A patient's doctor may refer them to a specialist to perform these tests. These tests can help confirm mesothelioma diagnosis and determine if it has spread to another part of the body. Imaging scans include X-rays CT (computer tomography) scans, MRI (magnetic resonance imaging) and PET (positron emission tomography). Doctors may also request a biopsy. A biopsy is carried out by removing a small amount of fluid or tissue from the tumor. It is then examined under a microscope for cancerous cells.

Diagnosis

Mesothelioma affects the surrounding tissues of organs. It is typically found in the lining (pleura) of the lungs, but can also affect the tissues surrounding the abdomen and heart. Exposure to asbestos can be at work or in construction materials. Asbestos is made up of a group minerals that can be sifted to form long, thin fibers. These fibres can be inhaled and cause mesothelioma once they enter the lung. Asbestos can also be sucked up and swallowed, which may cause mesothelioma of the peritoneal region. After exposure, mesothelioma can take up to 60 years to develop.

Although most mesotheliomas are caused by asbestos, other chemicals can cause the mesothelioma as well. Arsenic is found in drinking water that is contaminated and certain types of waste, and even certain foods. Asbestos can be spread through second-hand exposure, such as when people who have asbestos on their clothing or equipment bring those fibers home to their loved relatives. People in professions that involve frequent contact with asbestos - such as miners, shipyard workers, and construction personnel are at greater risk for exposure. Mesothelioma can be found in people who haven't been exposed to asbestos while at work.

The unique geography of northern Chile makes it an ideal location to study patterns over time of arsenic-related diseases. Antofagasta was the largest city in this region and had arsenic levels high in its drinking water from 1958 until 1970. The levels dropped after the installation of a water treatment plant.

Researchers found that arsenic exposure is linked to cancer in a case-control study involving 232 lung cancer cases, 306 bladder cancers and 640 gender- and age-matched controls. They also found that lung SqCCs associated with arsenic exposure exhibited distinctive genomic alterations not seen in non-arsenic-associated lung cancers.

These findings will help public health professionals plan strategies to reduce long-term risks and obtain the funds needed to implement them. They could also aid in improving the screening process for mesothelioma. Mesothelioma is typically diagnosed using X-rays, blood tests and an exploratory surgical procedure called biopsy.

Treatment

Mesothelioma is a rare cancer that is fatal, affects tissues around vital organs such as the abdomen or lungs. The condition is typically triggered by exposure to asbestos fibers however it could be triggered by the effects of contaminated water sources or other environmental contaminants. A doctor can diagnose mesothelioma after performing blood tests and imaging scans. Patients suffering from mesothelioma should inform their oncologists about all asbestos exposures they've had in the past to prevent an incorrect diagnosis.

Mesothelioma can trigger a myriad of symptoms, including difficulty breathing and chest pains. Men are more likely to be affected by mesothelioma more than women, and it can take up to 40 years to treat the disease after exposure. Mesothelioma is typically treated with chemotherapy, surgery, and radiation. However, this is not available to everyone suffering from mesothelioma. Patients should consult an expert.

A recent study of mesothelioma patients in northern Chile discovered that arsenic-related oxygenative stress triggers the mesothelioma. This oxidative strain triggers the production of free radicals that can harm DNA and increase the risk of mesothelioma and other diseases. Arsenic compounds, such as arsenite or arsenate, interfere with the cellular redox reaction and can interfere with phosphate transport. This can cause a depolarization in the mitochondrial membrane and a glutathione loss, which increases free radicals.

Asbestos and arsenic as well as radon are all recognized carcinogens of the lung, causing many molecular changes. These include epigenetic changes and mutations. modifications such as DNA methylation. Arsenic, asbestos, and other chemicals have been associated with mesothelioma of the pleural. This is the most prevalent mesothelioma type. When fibres are inhaled or coughed into the lungs, they can cause peritoneal cancer.

Northern Chile unlike many other regions that are highly exposed is home to only a few major water sources. These contain arsenic levels that are well-known and have extensive historical records. These factors allowed for accurate estimations of the lifetime exposure of the participants in the study. With this data researchers were able establish clear dose-response correlations between arsenic exposure and bladder cancers in smokers and nonsmokers. The results revealed that the risk of these cancers increased when the concentration of arsenic in drinking water rose.

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